SZGR2

Summary ?

GeneID	9173
Symbol	IL1RL1
Synonyms	DER4\|FIT-1\|IL33R\|ST2\|ST2L\|ST2V\|T1
Description	interleukin 1 receptor like 1
Reference	MIM:601203\|HGNC:HGNC:5998\|Ensembl:ENSG00000115602\|HPRD:03123\|Vega:OTTHUMG00000130782
Gene type	protein-coding
Map location	2q12
Fetal beta	-0.127
eGene	Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Nucleus accumbens basal ganglia Putamen basal ganglia Meta

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_I	Genome scan meta-analysis	Psr: 0.0004

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	TSS distance	eQTL type
rs1115282	2	102890970	IL1RL1	ENSG00000115602.12	1.482E-6	-38399	gtex_brain_ba24
rs11123917	2	102891649	IL1RL1	ENSG00000115602.12	1.466E-6	-37720	gtex_brain_ba24
rs11683213	2	102904244	IL1RL1	ENSG00000115602.12	9.108E-7	-25125	gtex_brain_ba24
rs1420091	2	102917234	IL1RL1	ENSG00000115602.12	2.669E-9	-12135	gtex_brain_ba24
rs4399750	2	102917788	IL1RL1	ENSG00000115602.12	2.789E-9	-11581	gtex_brain_ba24
rs2110660	2	102918601	IL1RL1	ENSG00000115602.12	1.04E-9	-10768	gtex_brain_ba24
rs35727090	2	102918925	IL1RL1	ENSG00000115602.12	3.071E-9	-10444	gtex_brain_ba24
rs200094563	2	102918931	IL1RL1	ENSG00000115602.12	1.635E-8	-10438	gtex_brain_ba24
rs1420090	2	102919305	IL1RL1	ENSG00000115602.12	2.963E-9	-10064	gtex_brain_ba24
rs7565653	2	102919426	IL1RL1	ENSG00000115602.12	2.789E-9	-9943	gtex_brain_ba24
rs7568913	2	102920037	IL1RL1	ENSG00000115602.12	9.885E-10	-9332	gtex_brain_ba24
rs10179654	2	102921783	IL1RL1	ENSG00000115602.12	9.388E-10	-7586	gtex_brain_ba24
rs4090473	2	102922987	IL1RL1	ENSG00000115602.12	2.789E-9	-6382	gtex_brain_ba24
rs67627960	2	102923677	IL1RL1	ENSG00000115602.12	2.224E-8	-5692	gtex_brain_ba24
rs11683957	2	102923821	IL1RL1	ENSG00000115602.12	1.17E-9	-5548	gtex_brain_ba24
rs12476925	2	102924549	IL1RL1	ENSG00000115602.12	7.474E-10	-4820	gtex_brain_ba24
rs12476968	2	102924662	IL1RL1	ENSG00000115602.12	7.545E-10	-4707	gtex_brain_ba24
rs6721346	2	102926320	IL1RL1	ENSG00000115602.12	7.474E-10	-3049	gtex_brain_ba24
rs10178436	2	102926511	IL1RL1	ENSG00000115602.12	7.474E-10	-2858	gtex_brain_ba24
rs11679191	2	102926800	IL1RL1	ENSG00000115602.12	7.508E-10	-2569	gtex_brain_ba24
rs11685424	2	102926981	IL1RL1	ENSG00000115602.12	7.474E-10	-2388	gtex_brain_ba24
rs11685480	2	102927086	IL1RL1	ENSG00000115602.12	2.789E-9	-2283	gtex_brain_ba24
rs6733174	2	102929012	IL1RL1	ENSG00000115602.12	7.474E-10	-357	gtex_brain_ba24
rs6543118	2	102929469	IL1RL1	ENSG00000115602.12	7.474E-10	100	gtex_brain_ba24
rs1558622	2	102930147	IL1RL1	ENSG00000115602.12	2.789E-9	778	gtex_brain_ba24
rs1558621	2	102930307	IL1RL1	ENSG00000115602.12	7.465E-10	938	gtex_brain_ba24
rs10189202	2	102930380	IL1RL1	ENSG00000115602.12	2.789E-9	1011	gtex_brain_ba24
rs34646353	2	102930605	IL1RL1	ENSG00000115602.12	3.322E-8	1236	gtex_brain_ba24
rs10191914	2	102930657	IL1RL1	ENSG00000115602.12	2.789E-9	1288	gtex_brain_ba24
rs10189711	2	102930881	IL1RL1	ENSG00000115602.12	7.474E-10	1512	gtex_brain_ba24
rs12712135	2	102930948	IL1RL1	ENSG00000115602.12	7.474E-10	1579	gtex_brain_ba24
rs1558620	2	102931395	IL1RL1	ENSG00000115602.12	2.789E-9	2026	gtex_brain_ba24
rs1558619	2	102931550	IL1RL1	ENSG00000115602.12	7.474E-10	2181	gtex_brain_ba24
rs12996505	2	102931802	IL1RL1	ENSG00000115602.12	2.789E-9	2433	gtex_brain_ba24
rs13020793	2	102931926	IL1RL1	ENSG00000115602.12	2.789E-9	2557	gtex_brain_ba24
rs10183388	2	102932247	IL1RL1	ENSG00000115602.12	2.789E-9	2878	gtex_brain_ba24
rs953934	2	102932293	IL1RL1	ENSG00000115602.12	6.343E-9	2924	gtex_brain_ba24
rs1968171	2	102933552	IL1RL1	ENSG00000115602.12	2.789E-9	4183	gtex_brain_ba24
rs4613307	2	102933758	IL1RL1	ENSG00000115602.12	2.789E-9	4389	gtex_brain_ba24
rs1968170	2	102933802	IL1RL1	ENSG00000115602.12	2.789E-9	4433	gtex_brain_ba24
rs11123918	2	102935237	IL1RL1	ENSG00000115602.12	2.986E-9	5868	gtex_brain_ba24
rs10182639	2	102935805	IL1RL1	ENSG00000115602.12	2.789E-9	6436	gtex_brain_ba24
rs11690443	2	102936131	IL1RL1	ENSG00000115602.12	2.789E-9	6762	gtex_brain_ba24
rs12712136	2	102936366	IL1RL1	ENSG00000115602.12	1.187E-8	6997	gtex_brain_ba24
rs974389	2	102936981	IL1RL1	ENSG00000115602.12	6.343E-9	7612	gtex_brain_ba24
rs4142132	2	102937482	IL1RL1	ENSG00000115602.12	2.789E-9	8113	gtex_brain_ba24
rs971764	2	102938335	IL1RL1	ENSG00000115602.12	6.343E-9	8966	gtex_brain_ba24
rs1420088	2	102939434	IL1RL1	ENSG00000115602.12	2.789E-9	10065	gtex_brain_ba24
rs11123920	2	102939833	IL1RL1	ENSG00000115602.12	2.789E-9	10464	gtex_brain_ba24
rs6706844	2	102940412	IL1RL1	ENSG00000115602.12	6.347E-9	11043	gtex_brain_ba24
rs11674832	2	102940999	IL1RL1	ENSG00000115602.12	2.456E-6	11630	gtex_brain_ba24
rs11675988	2	102941019	IL1RL1	ENSG00000115602.12	1.841E-6	11650	gtex_brain_ba24
rs11679900	2	102941074	IL1RL1	ENSG00000115602.12	2.789E-9	11705	gtex_brain_ba24
rs11676075	2	102941215	IL1RL1	ENSG00000115602.12	2.789E-9	11846	gtex_brain_ba24
rs11676124	2	102941338	IL1RL1	ENSG00000115602.12	1.834E-6	11969	gtex_brain_ba24
rs11123921	2	102941561	IL1RL1	ENSG00000115602.12	2.788E-9	12192	gtex_brain_ba24
rs76520363	2	102945241	IL1RL1	ENSG00000115602.12	2.789E-9	15872	gtex_brain_ba24
rs76278109	2	102945378	IL1RL1	ENSG00000115602.12	1.911E-7	16009	gtex_brain_ba24
rs76886731	2	102945416	IL1RL1	ENSG00000115602.12	8.213E-8	16047	gtex_brain_ba24
rs150341880	2	102945755	IL1RL1	ENSG00000115602.12	3.693E-9	16386	gtex_brain_ba24
rs138087973	2	102946082	IL1RL1	ENSG00000115602.12	1.489E-8	16713	gtex_brain_ba24
rs76498201	2	102946111	IL1RL1	ENSG00000115602.12	2.012E-8	16742	gtex_brain_ba24
rs12996772	2	102947201	IL1RL1	ENSG00000115602.12	2.789E-9	17832	gtex_brain_ba24
rs1420102	2	102948819	IL1RL1	ENSG00000115602.12	6.343E-9	19450	gtex_brain_ba24
rs12466380	2	102948939	IL1RL1	ENSG00000115602.12	2.789E-9	19570	gtex_brain_ba24
rs12712140	2	102951062	IL1RL1	ENSG00000115602.12	2.919E-9	21693	gtex_brain_ba24
rs1997467	2	102951073	IL1RL1	ENSG00000115602.12	2.789E-9	21704	gtex_brain_ba24
rs1997466	2	102951467	IL1RL1	ENSG00000115602.12	2.788E-9	22098	gtex_brain_ba24
rs1362350	2	102951798	IL1RL1	ENSG00000115602.12	2.797E-9	22429	gtex_brain_ba24
rs67058052	2	102951850	IL1RL1	ENSG00000115602.12	3.359E-9	22481	gtex_brain_ba24
rs397969654	2	102951851	IL1RL1	ENSG00000115602.12	3.301E-9	22482	gtex_brain_ba24
rs1362349	2	102951972	IL1RL1	ENSG00000115602.12	3.255E-9	22603	gtex_brain_ba24
rs12712141	2	102953067	IL1RL1	ENSG00000115602.12	1.112E-8	23698	gtex_brain_ba24
rs59247511	2	102954190	IL1RL1	ENSG00000115602.12	3.116E-9	24821	gtex_brain_ba24
rs55664618	2	103016216	IL1RL1	ENSG00000115602.12	1.563E-7	86847	gtex_brain_ba24
rs11465727	2	103064503	IL1RL1	ENSG00000115602.12	5.32E-7	135134	gtex_brain_ba24
rs11465730	2	103066858	IL1RL1	ENSG00000115602.12	5.994E-7	137489	gtex_brain_ba24
rs11678721	2	103073238	IL1RL1	ENSG00000115602.12	8.884E-7	143869	gtex_brain_ba24
rs11677555	2	103073293	IL1RL1	ENSG00000115602.12	5.994E-7	143924	gtex_brain_ba24
rs6728475	2	103073950	IL1RL1	ENSG00000115602.12	5.982E-7	144581	gtex_brain_ba24
rs12712150	2	103074813	IL1RL1	ENSG00000115602.12	5.817E-7	145444	gtex_brain_ba24
rs6705498	2	103076670	IL1RL1	ENSG00000115602.12	5.994E-7	147301	gtex_brain_ba24
rs6719196	2	103076888	IL1RL1	ENSG00000115602.12	5.994E-7	147519	gtex_brain_ba24
rs11676236	2	103081695	IL1RL1	ENSG00000115602.12	5.994E-7	152326	gtex_brain_ba24
rs11687013	2	103081721	IL1RL1	ENSG00000115602.12	5.994E-7	152352	gtex_brain_ba24
rs4140786	2	103088176	IL1RL1	ENSG00000115602.12	5.994E-7	158807	gtex_brain_ba24
rs1115282	2	102890970	IL1RL1	ENSG00000115602.12	5.141E-6	-38399	gtex_brain_putamen_basal
rs11123917	2	102891649	IL1RL1	ENSG00000115602.12	4.807E-6	-37720	gtex_brain_putamen_basal
rs11683213	2	102904244	IL1RL1	ENSG00000115602.12	2.673E-6	-25125	gtex_brain_putamen_basal
rs1420091	2	102917234	IL1RL1	ENSG00000115602.12	3.697E-9	-12135	gtex_brain_putamen_basal
rs4399750	2	102917788	IL1RL1	ENSG00000115602.12	3.739E-9	-11581	gtex_brain_putamen_basal
rs2110660	2	102918601	IL1RL1	ENSG00000115602.12	6.22E-11	-10768	gtex_brain_putamen_basal
rs35727090	2	102918925	IL1RL1	ENSG00000115602.12	1.591E-8	-10444	gtex_brain_putamen_basal
rs200094563	2	102918931	IL1RL1	ENSG00000115602.12	2.029E-8	-10438	gtex_brain_putamen_basal
rs1420090	2	102919305	IL1RL1	ENSG00000115602.12	9.865E-9	-10064	gtex_brain_putamen_basal
rs7565653	2	102919426	IL1RL1	ENSG00000115602.12	3.734E-9	-9943	gtex_brain_putamen_basal
rs7568913	2	102920037	IL1RL1	ENSG00000115602.12	5.897E-11	-9332	gtex_brain_putamen_basal
rs10179654	2	102921783	IL1RL1	ENSG00000115602.12	5.647E-11	-7586	gtex_brain_putamen_basal
rs4090473	2	102922987	IL1RL1	ENSG00000115602.12	3.723E-9	-6382	gtex_brain_putamen_basal
rs67627960	2	102923677	IL1RL1	ENSG00000115602.12	1.119E-8	-5692	gtex_brain_putamen_basal
rs12476925	2	102924549	IL1RL1	ENSG00000115602.12	5.277E-11	-4820	gtex_brain_putamen_basal
rs12476968	2	102924662	IL1RL1	ENSG00000115602.12	5.277E-11	-4707	gtex_brain_putamen_basal
rs6721346	2	102926320	IL1RL1	ENSG00000115602.12	5.277E-11	-3049	gtex_brain_putamen_basal
rs10178436	2	102926511	IL1RL1	ENSG00000115602.12	5.277E-11	-2858	gtex_brain_putamen_basal
rs11679191	2	102926800	IL1RL1	ENSG00000115602.12	2.025E-11	-2569	gtex_brain_putamen_basal
rs11685424	2	102926981	IL1RL1	ENSG00000115602.12	5.277E-11	-2388	gtex_brain_putamen_basal
rs11685480	2	102927086	IL1RL1	ENSG00000115602.12	3.739E-9	-2283	gtex_brain_putamen_basal
rs6733174	2	102929012	IL1RL1	ENSG00000115602.12	5.246E-11	-357	gtex_brain_putamen_basal
rs6543118	2	102929469	IL1RL1	ENSG00000115602.12	5.264E-11	100	gtex_brain_putamen_basal
rs1558622	2	102930147	IL1RL1	ENSG00000115602.12	3.734E-9	778	gtex_brain_putamen_basal
rs1558621	2	102930307	IL1RL1	ENSG00000115602.12	5.272E-11	938	gtex_brain_putamen_basal
rs10189202	2	102930380	IL1RL1	ENSG00000115602.12	3.736E-9	1011	gtex_brain_putamen_basal
rs34646353	2	102930605	IL1RL1	ENSG00000115602.12	5.274E-9	1236	gtex_brain_putamen_basal
rs10191914	2	102930657	IL1RL1	ENSG00000115602.12	3.739E-9	1288	gtex_brain_putamen_basal
rs10189711	2	102930881	IL1RL1	ENSG00000115602.12	5.277E-11	1512	gtex_brain_putamen_basal
rs12712135	2	102930948	IL1RL1	ENSG00000115602.12	5.277E-11	1579	gtex_brain_putamen_basal
rs1558620	2	102931395	IL1RL1	ENSG00000115602.12	3.739E-9	2026	gtex_brain_putamen_basal
rs1558619	2	102931550	IL1RL1	ENSG00000115602.12	8.541E-11	2181	gtex_brain_putamen_basal
rs12996505	2	102931802	IL1RL1	ENSG00000115602.12	3.976E-9	2433	gtex_brain_putamen_basal
rs13020793	2	102931926	IL1RL1	ENSG00000115602.12	3.739E-9	2557	gtex_brain_putamen_basal
rs10183388	2	102932247	IL1RL1	ENSG00000115602.12	3.739E-9	2878	gtex_brain_putamen_basal
rs953934	2	102932293	IL1RL1	ENSG00000115602.12	2.409E-9	2924	gtex_brain_putamen_basal
rs1968171	2	102933552	IL1RL1	ENSG00000115602.12	4.305E-9	4183	gtex_brain_putamen_basal
rs4613307	2	102933758	IL1RL1	ENSG00000115602.12	1.903E-9	4389	gtex_brain_putamen_basal
rs1968170	2	102933802	IL1RL1	ENSG00000115602.12	4.466E-9	4433	gtex_brain_putamen_basal
rs11123918	2	102935237	IL1RL1	ENSG00000115602.12	8.056E-9	5868	gtex_brain_putamen_basal
rs10182639	2	102935805	IL1RL1	ENSG00000115602.12	9.348E-9	6436	gtex_brain_putamen_basal
rs11690443	2	102936131	IL1RL1	ENSG00000115602.12	1.004E-8	6762	gtex_brain_putamen_basal
rs12712136	2	102936366	IL1RL1	ENSG00000115602.12	1.02E-8	6997	gtex_brain_putamen_basal
rs974389	2	102936981	IL1RL1	ENSG00000115602.12	6.68E-9	7612	gtex_brain_putamen_basal
rs4142132	2	102937482	IL1RL1	ENSG00000115602.12	1.289E-8	8113	gtex_brain_putamen_basal
rs971764	2	102938335	IL1RL1	ENSG00000115602.12	8.101E-9	8966	gtex_brain_putamen_basal
rs1420088	2	102939434	IL1RL1	ENSG00000115602.12	1.557E-8	10065	gtex_brain_putamen_basal
rs11123920	2	102939833	IL1RL1	ENSG00000115602.12	1.557E-8	10464	gtex_brain_putamen_basal
rs6706844	2	102940412	IL1RL1	ENSG00000115602.12	8.767E-9	11043	gtex_brain_putamen_basal
rs11674832	2	102940999	IL1RL1	ENSG00000115602.12	1.414E-6	11630	gtex_brain_putamen_basal
rs11679900	2	102941074	IL1RL1	ENSG00000115602.12	1.68E-8	11705	gtex_brain_putamen_basal
rs11676075	2	102941215	IL1RL1	ENSG00000115602.12	1.557E-8	11846	gtex_brain_putamen_basal
rs11123921	2	102941561	IL1RL1	ENSG00000115602.12	1.557E-8	12192	gtex_brain_putamen_basal
rs76520363	2	102945241	IL1RL1	ENSG00000115602.12	1.557E-8	15872	gtex_brain_putamen_basal
rs76278109	2	102945378	IL1RL1	ENSG00000115602.12	9.603E-7	16009	gtex_brain_putamen_basal
rs76886731	2	102945416	IL1RL1	ENSG00000115602.12	1.01E-7	16047	gtex_brain_putamen_basal
rs150341880	2	102945755	IL1RL1	ENSG00000115602.12	1.238E-8	16386	gtex_brain_putamen_basal
rs138087973	2	102946082	IL1RL1	ENSG00000115602.12	1.876E-8	16713	gtex_brain_putamen_basal
rs76498201	2	102946111	IL1RL1	ENSG00000115602.12	1.106E-8	16742	gtex_brain_putamen_basal
rs12996772	2	102947201	IL1RL1	ENSG00000115602.12	1.557E-8	17832	gtex_brain_putamen_basal
rs1420102	2	102948819	IL1RL1	ENSG00000115602.12	8.979E-9	19450	gtex_brain_putamen_basal
rs12466380	2	102948939	IL1RL1	ENSG00000115602.12	1.557E-8	19570	gtex_brain_putamen_basal
rs12712140	2	102951062	IL1RL1	ENSG00000115602.12	1.641E-8	21693	gtex_brain_putamen_basal
rs1997467	2	102951073	IL1RL1	ENSG00000115602.12	1.557E-8	21704	gtex_brain_putamen_basal
rs1997466	2	102951467	IL1RL1	ENSG00000115602.12	1.556E-8	22098	gtex_brain_putamen_basal
rs1362350	2	102951798	IL1RL1	ENSG00000115602.12	1.555E-8	22429	gtex_brain_putamen_basal
rs67058052	2	102951850	IL1RL1	ENSG00000115602.12	2.031E-8	22481	gtex_brain_putamen_basal
rs397969654	2	102951851	IL1RL1	ENSG00000115602.12	1.238E-8	22482	gtex_brain_putamen_basal
rs1362349	2	102951972	IL1RL1	ENSG00000115602.12	1.63E-8	22603	gtex_brain_putamen_basal
rs12712141	2	102953067	IL1RL1	ENSG00000115602.12	1.557E-8	23698	gtex_brain_putamen_basal
rs59247511	2	102954190	IL1RL1	ENSG00000115602.12	1.565E-8	24821	gtex_brain_putamen_basal
rs55664618	2	103016216	IL1RL1	ENSG00000115602.12	3.774E-7	86847	gtex_brain_putamen_basal
rs11465727	2	103064503	IL1RL1	ENSG00000115602.12	4.008E-7	135134	gtex_brain_putamen_basal
rs35566453	2	103064508	IL1RL1	ENSG00000115602.12	3.31E-6	135139	gtex_brain_putamen_basal
rs397873851	2	103064511	IL1RL1	ENSG00000115602.12	3.335E-6	135142	gtex_brain_putamen_basal
rs11465730	2	103066858	IL1RL1	ENSG00000115602.12	7.279E-7	137489	gtex_brain_putamen_basal
rs11678721	2	103073238	IL1RL1	ENSG00000115602.12	3.15E-6	143869	gtex_brain_putamen_basal
rs11677555	2	103073293	IL1RL1	ENSG00000115602.12	7.279E-7	143924	gtex_brain_putamen_basal
rs6728475	2	103073950	IL1RL1	ENSG00000115602.12	7.279E-7	144581	gtex_brain_putamen_basal
rs12712150	2	103074813	IL1RL1	ENSG00000115602.12	6.749E-7	145444	gtex_brain_putamen_basal
rs6705385	2	103076569	IL1RL1	ENSG00000115602.12	2.243E-6	147200	gtex_brain_putamen_basal
rs6705498	2	103076670	IL1RL1	ENSG00000115602.12	7.279E-7	147301	gtex_brain_putamen_basal
rs6719196	2	103076888	IL1RL1	ENSG00000115602.12	7.279E-7	147519	gtex_brain_putamen_basal
rs11676236	2	103081695	IL1RL1	ENSG00000115602.12	7.279E-7	152326	gtex_brain_putamen_basal
rs11687013	2	103081721	IL1RL1	ENSG00000115602.12	7.279E-7	152352	gtex_brain_putamen_basal
rs12463588	2	103085257	IL1RL1	ENSG00000115602.12	2.243E-6	155888	gtex_brain_putamen_basal
rs2310302	2	103086049	IL1RL1	ENSG00000115602.12	2.243E-6	156680	gtex_brain_putamen_basal
rs12469887	2	103086758	IL1RL1	ENSG00000115602.12	2.243E-6	157389	gtex_brain_putamen_basal
rs10195075	2	103087652	IL1RL1	ENSG00000115602.12	1.891E-6	158283	gtex_brain_putamen_basal
rs1403553	2	103087662	IL1RL1	ENSG00000115602.12	1.891E-6	158293	gtex_brain_putamen_basal
rs4140786	2	103088176	IL1RL1	ENSG00000115602.12	7.279E-7	158807	gtex_brain_putamen_basal
rs10201184	2	103089078	IL1RL1	ENSG00000115602.12	2.243E-6	159709	gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ANKRD44	0.91	0.92
RRP1B	0.91	0.92
SEC24A	0.91	0.95
PRRC1	0.90	0.92
SPAST	0.90	0.94
IGSF3	0.90	0.89
URB2	0.90	0.92
EPM2AIP1	0.90	0.93
MFHAS1	0.90	0.90
ZXDA	0.90	0.92

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
FXYD1	-0.66	-0.84
AF347015.31	-0.64	-0.81
MT-CO2	-0.64	-0.82
IFI27	-0.63	-0.80
C5orf53	-0.63	-0.71
AF347015.33	-0.63	-0.79
CXCL14	-0.62	-0.82
AF347015.27	-0.62	-0.78
HIGD1B	-0.62	-0.80
HLA-F	-0.61	-0.70

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005057	receptor signaling protein activity	TAS		1482686
GO:0004888	transmembrane receptor activity	IEA		-
GO:0005515	protein binding	IPI		16286016
GO:0004908	interleukin-1 receptor activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007165	signal transduction	TAS		1482686
GO:0045087	innate immune response	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005813	centrosome	IDA		18029348
GO:0005576	extracellular region	IEA		-
GO:0005737	cytoplasm	IDA		18029348
GO:0016021	integral to membrane	IEA		-
GO:0005925	focal adhesion	IDA		18029348
GO:0005886	plasma membrane	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP	185	126	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 DN	51	35	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP	126	72	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 UP	120	73	All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP	115	78	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM DN	25	18	All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 2 UP	64	45	All SZGR 2.0 genes in this pathway
WATTEL AUTONOMOUS THYROID ADENOMA DN	55	29	All SZGR 2.0 genes in this pathway
SASAI RESISTANCE TO NEOPLASTIC TRANSFROMATION	50	31	All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER LARGE VS TINY DN	45	24	All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER C	113	47	All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS	183	115	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL FLI1	9	8	All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS UP	88	64	All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN	234	137	All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION	405	264	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR	544	307	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP	244	151	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 2	72	52	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP	178	111	All SZGR 2.0 genes in this pathway
HAN JNK SINGALING UP	35	21	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 8HR	39	31	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP	393	244	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P4	100	62	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP	295	149	All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING DN	42	26	All SZGR 2.0 genes in this pathway
MATTHEWS AP1 TARGETS	17	12	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP	198	128	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN	252	155	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G24	28	19	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP C	92	60	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP	271	165	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS DN	148	88	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP	199	143	All SZGR 2.0 genes in this pathway
WANG MLL TARGETS	289	188	All SZGR 2.0 genes in this pathway
DURAND STROMA S UP	297	194	All SZGR 2.0 genes in this pathway

Gene Page: IL1RL1