Gene Page: POLR1C

Summary
GeneID  9533
Symbol  POLR1C
Synonyms  RPA39|RPA40|RPA5|RPAC1
Description  polymerase (RNA) I polypeptide C, 30kDa
See related  HGNC:20194|MIM:610060|Ensembl:ENSG00000171453|HPRD:09661|
Locus tag  RP3-337H4.4
Gene type  protein-coding
Map location  6p21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CNTNAP10.930.88
KCNJ90.910.88
GABARAPL30.900.89
NPTN0.900.87
CAMTA20.900.92
EHD30.900.87
SYNGR10.900.85
SLC12A50.900.90
RPH3A0.890.82
PTPRN0.890.89
Top 10 negatively co-expressed genes
BCL7C-0.54-0.62
C9orf46-0.49-0.50
RPL23A-0.47-0.53
RPL35-0.47-0.54
RPL18-0.47-0.55
RPS19P3-0.47-0.57
RPS18-0.46-0.48
RPS8-0.46-0.48
RPLP1-0.46-0.50
RPS6-0.46-0.49
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0003899DNA-directed RNA polymerase activityIEA-
GO:0003899DNA-directed RNA polymerase activityTAS9540830 
GO:0046983protein dimerization activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006350transcriptionIEA-
GO:0006360transcription from RNA polymerase I promoterTAS9540830 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP9582279 |12393749 |12646563 
GO:0005736DNA-directed RNA polymerase I complexTAS9540830 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD3EAPASE-1 | CAST | MGC118851 | PAF49CD3e molecule, epsilon associated proteinCo-fractionation
Far Western		BioGRID15226435 
NME1AWD | GAAD | NB | NBS | NDPK-A | NDPKA | NM23 | NM23-H1non-metastatic cells 1, protein (NM23A) expressed inTwo-hybridBioGRID16189514 
POLR1DFLJ20616 | MGC9850 | POLR1C | RPA16 | RPA9 | RPAC2 | RPO1-3polymerase (RNA) I polypeptide D, 16kDaTwo-hybridBioGRID8955128 |16189514 
POLR1EFLJ13390 | FLJ13970 | PAF53 | PRAF1 | RP11-405L18.3polymerase (RNA) I polypeptide E, 53kDaAffinity Capture-MS
Co-purification
Far Western		BioGRID9254723 |15226435 
|17353931 
POLR3DBN51T | RPC4 | RPC53 | TSBN51polymerase (RNA) III (DNA directed) polypeptide D, 44kDaAffinity Capture-MSBioGRID12391170 
WRNDKFZp686C2056 | RECQ3 | RECQL2 | RECQL3Werner syndrome-HPRD,BioGRID11971179 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PURINE_METABOLISM 15996All SZGR genes in this pathway
KEGG_PYRIMIDINE_METABOLISM 9853All SZGR genes in this pathway
KEGG_RNA_POLYMERASE 2912All SZGR genes in this pathway
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 5644All SZGR genes in this pathway
BIOCARTA_ARF_PATHWAY 1713All SZGR genes in this pathway
REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER 2312All SZGR genes in this pathway
REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION 2212All SZGR genes in this pathway
REACTOME_RNA_POL_I_TRANSCRIPTION 8964All SZGR genes in this pathway
REACTOME_RNA_POL_III_TRANSCRIPTION 3318All SZGR genes in this pathway
REACTOME_TRANSCRIPTION 210127All SZGR genes in this pathway
REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 12280All SZGR genes in this pathway
REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER 2613All SZGR genes in this pathway
REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION 1910All SZGR genes in this pathway
REACTOME_RNA_POL_III_CHAIN_ELONGATION 178All SZGR genes in this pathway
REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION 2514All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_WITH_7Q_DELETION_DN 3623All SZGR genes in this pathway
GRASEMANN_RETINOBLASTOMA_WITH_6P_AMPLIFICATION 1414All SZGR genes in this pathway
AMUNDSON_RESPONSE_TO_ARSENITE 217143All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP 205126All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 6348All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_DN 7657All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
MODY_HIPPOCAMPUS_PRENATAL 4233All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP 425253All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
BILANGES_RAPAMYCIN_SENSITIVE_VIA_TSC1_AND_TSC2 7337All SZGR genes in this pathway


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