Gene Page: CDH5

Summary
GeneID  1003
Symbol  CDH5
Synonyms  7B4|CD144|FLJ17376
Description  cadherin 5, type 2 (vascular endothelium)
See related  HGNC:1764|MIM:601120|Ensembl:ENSG00000179776|HPRD:03075|
Locus tag  -
Gene type  protein-coding
Map location  16q22.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PPFIA20.790.81
R3HDM10.780.84
PVRL30.780.84
FGF140.780.80
TM6SF10.770.81
LRRC4C0.760.81
JAZF10.760.81
ZNF5400.760.78
L3MBTL40.760.80
GPR1760.750.83
Top 10 negatively co-expressed genes
AC098691.2-0.54-0.59
MT-CO2-0.54-0.48
FXYD1-0.53-0.45
AF347015.21-0.53-0.45
AF347015.33-0.52-0.44
HIGD1B-0.52-0.48
AC021016.1-0.52-0.49
AP002478.3-0.52-0.53
ACSF2-0.51-0.53
AF347015.8-0.51-0.45
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIPINeurotransmitter (GO term level: 4)12088286 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001955blood vessel maturationIEA-
GO:0007155cell adhesionIEA-
GO:0007156homophilic cell adhesionIEA-
GO:0007156homophilic cell adhesionTAS9219219 
GO:0008285negative regulation of cell proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005923tight junctionIEABrain (GO term level: 10)-
GO:0005624membrane fractionTAS9219219 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS9219219 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CSKMGC117393c-src tyrosine kinaseCDH5 (VE-cadherin) interacts with CSK.BIND15861137 
CTNNA1CAP102 | FLJ36832catenin (cadherin-associated protein), alpha 1, 102kDa-HPRD,BioGRID12003790 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD12413882 
Affinity Capture-WesternBioGRID9434630 |12003790 
CTNND1CAS | CTNND | KIAA0384 | P120CAS | P120CTN | p120catenin (cadherin-associated protein), delta 1-HPRD,BioGRID11855855 
DSPDPI | DPIIdesmoplakin-HPRD,BioGRID9739078 
FGAFib2 | MGC119422 | MGC119423 | MGC119425fibrinogen alpha chain-HPRD,BioGRID11900554 
FGBMGC104327 | MGC120405fibrinogen beta chainB-beta(15-42) interacts with CDH5 (VE-cadherin).BIND15723073 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobin-HPRD9739078 |12003790 
Affinity Capture-WesternBioGRID9434630 |12003790 
KDRCD309 | FLK1 | VEGFR | VEGFR2kinase insert domain receptor (a type III receptor tyrosine kinase)Affinity Capture-WesternBioGRID11950700 
-HPRD10428027 
P2RX4P2X4 | P2X4Rpurinergic receptor P2X, ligand-gated ion channel, 4Affinity Capture-WesternBioGRID12088286 
P2RX6MGC129625 | P2RXL1 | P2X6 | P2XMpurinergic receptor P2X, ligand-gated ion channel, 6-HPRD12088286 
PKP4FLJ31261 | FLJ42243 | p0071plakophilin 4-HPRD,BioGRID12426320 
p0071 interacts with VE-cadherin.BIND12426320 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD,BioGRID10681592 
PTPRBDKFZp686E2262 | DKFZp686H15164 | FLJ44133 | HPTP-BETA | HPTPB | MGC142023 | MGC59935 | PTPB | R-PTP-BETA | VEPTPprotein tyrosine phosphatase, receptor type, BAffinity Capture-Western
Biochemical Activity		BioGRID12234928 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID11950700 
SMG161E3.4 | ATX | KIAA0421 | LIPPI-3-kinase-related kinase SMG-1-HPRD10428027 
VIMFLJ36605vimentin-HPRD,BioGRID12003790 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
PID_S1P_S1P2_PATHWAY 2419All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS 2720All SZGR genes in this pathway
REACTOME_CELL_CELL_JUNCTION_ORGANIZATION 5631All SZGR genes in this pathway
REACTOME_CELL_JUNCTION_ORGANIZATION 7843All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 205140All SZGR genes in this pathway
ROY_WOUND_BLOOD_VESSEL_UP 5030All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN 234147All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP 214144All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN 6244All SZGR genes in this pathway
CALVET_IRINOTECAN_SENSITIVE_VS_REVERTED_DN 55All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
RANKIN_ANGIOGENIC_TARGETS_OF_VHL_HIF2A_DN 87All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_UP 157105All SZGR genes in this pathway
GUO_HEX_TARGETS_DN 6536All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101156615731A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-1287157211Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-143107710831Ahsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-144156715731Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-277157221A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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