Gene Page: CDK4

Summary
GeneID  1019
Symbol  CDK4
Synonyms  CMM3|MGC14458|PSK-J3
Description  cyclin-dependent kinase 4
See related  HGNC:1773|MIM:123829|Ensembl:ENSG00000135446|HPRD:00447|
Locus tag  -
Gene type  protein-coding
Map location  12q14
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1875 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TUBGCP60.920.94
WDR590.900.91
RHOT20.890.88
LZTR10.890.91
SH2B10.880.91
NDST20.880.90
COG70.880.90
ZSWIM10.880.89
ANKS30.880.90
ABCC100.870.91
Top 10 negatively co-expressed genes
AF347015.21-0.72-0.78
AF347015.31-0.71-0.73
AF347015.27-0.70-0.72
MT-CO2-0.69-0.71
AF347015.8-0.68-0.70
MT-CYB-0.67-0.68
AF347015.33-0.65-0.66
AF347015.15-0.64-0.66
MT-ATP8-0.62-0.73
AF347015.2-0.62-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004693cyclin-dependent protein kinase activityIEAneuron (GO term level: 8)-
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI9106657 |11896535 |15232106 
|15558030 |16169070 
|17274640 |17353931 
|17909018 
GO:0005524ATP bindingIEA-
GO:0004672protein kinase activityIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000082G1/S transition of mitotic cell cycleIMP7603984 
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionIEA-
GO:0010468regulation of gene expressionIMP17420273 
GO:0051301cell divisionIEA-
GO:0048146positive regulation of fibroblast proliferationIMP17420273 
GO:0051726regulation of cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000307cyclin-dependent protein kinase holoenzyme complexIEA-
GO:0005829cytosolEXP9106657 
GO:0005634nucleusIDA16109376 
GO:0005654nucleoplasmEXP9190208 |16782892 
GO:0005667transcription factor complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTR3BARP11 | ARP3BETA | DKFZp686O24114ARP3 actin-related protein 3 homolog B (yeast)Affinity Capture-MSBioGRID17353931 
BAT3BAG-6 | BAG6 | D6S52E | G3HLA-B associated transcript 3Two-hybridBioGRID16169070 
BIRC5API4 | EPR-1baculoviral IAP repeat-containing 5-HPRD,BioGRID10713676 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID9244350 
BRCA1 associates with CDK4BIND9244350 
CAPNS130K | CALPAIN4 | CANP | CANPS | CAPN4 | CDPScalpain, small subunit 1Two-hybridBioGRID16169070 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1-HPRD9150368 |9837900 
CDK4 interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between human CDK4 and Cyclin D1 from an unspecified species.BIND9228064 
CCND1 (cyclin D1) interacts with CDK4.BIND8662825 
Affinity Capture-Western
Reconstituted Complex		BioGRID8259215 |9837900 
|10580009 |11360184 
CCND2KIAK0002 | MGC102758cyclin D2CCND2 interacts with CDK4BIND11291051 
-HPRD,BioGRID11358847 
CCND3-cyclin D3-HPRD,BioGRID10342870 
CDC37P50CDC37cell division cycle 37 homolog (S. cerevisiae)-HPRD,BioGRID8666233 |8703009 
CDC7CDC7L1 | HsCDC7 | Hsk1 | MGC117361 | MGC126237 | MGC126238 | huCDC7cell division cycle 7 homolog (S. cerevisiae)-HPRD15232106 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)Cdk4 interacts with p21.BIND8999999 
CDKN1BCDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1cyclin-dependent kinase inhibitor 1B (p27, Kip1)-HPRD,BioGRID10908655 
CDKN2AARF | CDK4I | CDKN2 | CMM2 | INK4 | INK4a | MLM | MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)p16 interacts with cdk4. This interaction was modeled on a demonstrated interaction between human p16 and cdk4 from an unspecified species.BIND9482104 
CDKN2A interacts with CDK4BIND11556834 
-HPRD,BioGRID9228064 
-HPRD9228064 |15232106 
p16 interacts with CDK4. This interaction was modeled on a demonstrated interaction between human p16 and CDK4 from an unspecified species.BIND10491434 
p16 interacts with cdk4.BIND8805225 
CDKN2BCDK4I | INK4B | MTS2 | P15 | TP15 | p15INK4bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)-HPRD7478582 |9111314 
|9163429 
in vitro
in vivo
Two-hybrid		BioGRID9163429 |16169070 
|16189514 
CDKN2CINK4C | p18 | p18-INK4Ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)-HPRD,BioGRID8001816 
An unspecified isoform of p18 interacts with cdk4. This interaction was modeled on a demonstrated interaction between human p18 and cdk4 from an unspecified species.BIND9482104 
CDKN2DINK4D | p19 | p19-INK4Dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)Two-hybridBioGRID16189514 
CEBPAC/EBP-alpha | CEBPCCAAT/enhancer binding protein (C/EBP), alpha-HPRD,BioGRID11684017 
CNOT7CAF1 | hCAF-1CCR4-NOT transcription complex, subunit 7-HPRD,BioGRID10602502 
DBNLABP1 | HIP-55 | SH3P7drebrin-likeAffinity Capture-MSBioGRID17353931 
GEMIN4DKFZp434B131 | DKFZp434D174 | HC56 | HCAP1 | HHRF-1 | p97gem (nuclear organelle) associated protein 4Affinity Capture-MSBioGRID17353931 
IFI27FAM14D | ISG12 | ISG12A | P27interferon, alpha-inducible protein 27-HPRD9837900 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homologAffinity Capture-MSBioGRID17353931 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)MYC (c-Myc) interacts with CDK4 promoter.BIND12857727 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1-HPRD,BioGRID10022835 |10601020 
ORC3LLAT | LATHEO | ORC3origin recognition complex, subunit 3-like (yeast)-HPRD15232106 
PCNAMGC8367proliferating cell nuclear antigenAffinity Capture-WesternBioGRID8259215 
PSMD10dJ889N15.2 | p28proteasome (prosome, macropain) 26S subunit, non-ATPase, 10-HPRD,BioGRID11779854 
PTMAMGC104802 | TMSAprothymosin, alpha-HPRD11310559 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1CDK4 phosphorylates Rb carboxy-terminus. This interaction was modelled on a demonstrated interaction between human Rb and mouse CDK4.BIND15241418 
RFC1A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140replication factor C (activator 1) 1, 145kDa-HPRD,BioGRID10353443 
RPRMFLJ90327 | REPRIMOreprimo, TP53 dependent G2 arrest mediator candidateAffinity Capture-MSBioGRID17353931 
SERTAD1SEI1 | TRIP-Br1SERTA domain containing 1-HPRD,BioGRID10580009 |15065884 
SETDB1ESET | KG1T | KIAA0067 | KMT1ESET domain, bifurcated 1Two-hybridBioGRID16169070 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2CDK4 phosphorylates Smad2. This interaction was modelled on a demonstrated interaction between Smad2 from an unspecified species and mouse CDK4.BIND15241418 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3CDK4 phosphorylates Smad3 on Thr8, Thr179, Ser204, Ser208 and Ser213. This interaction was modelled on a demonstrated interaction between Smad3 from an unspecified species and mouse CDK4.BIND15241418 
SMC1ACDLS2 | DKFZp686L19178 | DXS423E | KIAA0178 | MGC138332 | SB1.8 | SMC1 | SMC1L1 | SMC1alpha | SMCBstructural maintenance of chromosomes 1AAffinity Capture-MSBioGRID17353931 
SMC3BAM | BMH | CDLS3 | CSPG6 | HCAP | SMC3L1structural maintenance of chromosomes 3Affinity Capture-MSBioGRID17353931 
UBXN12B28 | UBXD10UBX domain protein 1Affinity Capture-MSBioGRID17353931 
VTA1C6orf55 | DRG-1 | DRG1 | FLJ27228 | HSPC228 | LIP5 | My012 | SBP1Vps20-associated 1 homolog (S. cerevisiae)Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_P53_SIGNALING_PATHWAY 6945All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
KEGG_BLADDER_CANCER 4233All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA 7359All SZGR genes in this pathway
KEGG_SMALL_CELL_LUNG_CANCER 8467All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER 5447All SZGR genes in this pathway
BIOCARTA_G1_PATHWAY 2821All SZGR genes in this pathway
BIOCARTA_CELLCYCLE_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_RACCYCD_PATHWAY 2623All SZGR genes in this pathway
BIOCARTA_P53_PATHWAY 1613All SZGR genes in this pathway
BIOCARTA_RB_PATHWAY 1311All SZGR genes in this pathway
SA_G1_AND_S_PHASES 1510All SZGR genes in this pathway
SA_REG_CASCADE_OF_CYCLIN_EXPR 137All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_NFAT_TFPATHWAY 4739All SZGR genes in this pathway
PID_MYC_ACTIV_PATHWAY 7962All SZGR genes in this pathway
PID_ATF2_PATHWAY 5943All SZGR genes in this pathway
PID_FOXM1_PATHWAY 4030All SZGR genes in this pathway
PID_RB_1PATHWAY 6546All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_MEIOSIS 11681All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_G1_PHASE 3823All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 7253All SZGR genes in this pathway
REACTOME_MEIOTIC_RECOMBINATION 8662All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP 316190All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
CAIRO_PML_TARGETS_BOUND_BY_MYC_UP 2317All SZGR genes in this pathway
JOHANSSON_GLIOMAGENESIS_BY_PDGFB_UP 5844All SZGR genes in this pathway
NUNODA_RESPONSE_TO_DASATINIB_IMATINIB_UP 2920All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_1 4527All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_21 95All SZGR genes in this pathway
HEIDENBLAD_AMPLIFIED_IN_SOFT_TISSUE_CANCER 137All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_5 1811All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_12Q13_Q21_AMPLICON 4621All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_COPY_NUMBER_UP 7536All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
MENSSEN_MYC_TARGETS 5335All SZGR genes in this pathway
SCHUHMACHER_MYC_TARGETS_UP 8057All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_DN 245154All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_UP 5035All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_DN 12986All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_DN 1914All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_HEREDITARY_VS_SPORADIC 5032All SZGR genes in this pathway
JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN 6445All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
WU_HBX_TARGETS_3_UP 1811All SZGR genes in this pathway
MACLACHLAN_BRCA1_TARGETS_UP 2116All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_DN 6444All SZGR genes in this pathway
ZHANG_RESPONSE_TO_CANTHARIDIN_DN 6946All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
MODY_HIPPOCAMPUS_PRENATAL 4233All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN 8858All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
LY_AGING_OLD_DN 5635All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_DN 14192All SZGR genes in this pathway
BURTON_ADIPOGENESIS_9 9259All SZGR genes in this pathway
BILD_MYC_ONCOGENIC_SIGNATURE 206117All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC 210123All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
MATZUK_CENTRAL_FOR_FEMALE_FERTILITY 2925All SZGR genes in this pathway
MATZUK_LUTEAL_GENES 85All SZGR genes in this pathway
WHITEFORD_PEDIATRIC_CANCER_MARKERS 11663All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_DN 175103All SZGR genes in this pathway
ZHAN_VARIABLE_EARLY_DIFFERENTIATION_GENES_DN 3019All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN 193112All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
DANG_MYC_TARGETS_UP 143100All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17 181101All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
LE_NEURONAL_DIFFERENTIATION_DN 1916All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.11311381A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-4862582641Ahsa-miR-486UCCUGUACUGAGCUGCCCCGAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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