Gene Page: CDK7

Summary
GeneID  1022
Symbol  CDK7
Synonyms  CAK1|CDKN7|MO15|STK1|p39MO15
Description  cyclin-dependent kinase 7
See related  HGNC:1778|MIM:601955|Ensembl:ENSG00000134058|HPRD:15993|
Locus tag  -
Gene type  protein-coding
Map location  5q12.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BOK0.800.82
SLC26A110.750.70
VAT10.740.67
RGS190.730.58
EPS8L10.710.41
RAC30.710.52
MVK0.710.73
PIP5KL10.690.51
NAGLU0.690.70
RNF2200.680.57
Top 10 negatively co-expressed genes
AF347015.31-0.45-0.57
MT-CO2-0.44-0.57
AF347015.8-0.42-0.56
AF347015.21-0.42-0.60
MT-CYB-0.41-0.55
CXCL14-0.41-0.53
AF347015.27-0.41-0.53
CARD16-0.40-0.58
AF347015.33-0.40-0.51
EAF2-0.40-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004693cyclin-dependent protein kinase activityTASneuron (GO term level: 8)8208544 
GO:0000166nucleotide bindingIEA-
GO:0003713transcription coactivator activityNAS15572661 
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
GO:0008353RNA polymerase subunit kinase activityIEA-
GO:0008022protein C-terminus bindingIPI10801852 
GO:0050681androgen receptor bindingNAS15572661 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000079regulation of cyclin-dependent protein kinase activityTAS7533895 
GO:0000718nucleotide-excision repair, DNA damage removalEXP10583946 
GO:0006367transcription initiation from RNA polymerase II promoterEXP8946909 
GO:0006367transcription initiation from RNA polymerase II promoterTAS7533895 
GO:0006368RNA elongation from RNA polymerase II promoterEXP9405375 
GO:0006350transcriptionIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0006281DNA repairIEA-
GO:0007049cell cycleIEA-
GO:0008283cell proliferationTAS7533895 
GO:0051301cell divisionIEA-
GO:0030521androgen receptor signaling pathwayNAS15572661 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA8692841 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA16109376 
GO:0005654nucleoplasmEXP1939271 |2449431 |7629134 
|7799941 |8946909 
|9512541 |9582279 
|9790902 |10214908 
|11313499 |12393749 
|12646563 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorAffinity Capture-Western
Reconstituted Complex		BioGRID10734072 
CCNHCAK | p34 | p37cyclin HAffinity Capture-MS
Affinity Capture-Western
Two-hybrid		BioGRID8078587 
-HPRD9056480 
CDK2p33(CDK2)cyclin-dependent kinase 2CDK7 phosphorylates an unspecified isoform of CDK2.BIND7629134 
CDK6MGC59692 | PLSTIRE | STQTL11cyclin-dependent kinase 6CAK phosphorylates CDK6. This interaction was modeled on a demonstrated interaction between human CAK and CDK6 from an unspecified species.BIND7629134 
CUX1CASP | CDP | CDP/Cut | CDP1 | COY1 | CUTL1 | CUX | Clox | Cux/CDP | GOLIM6 | Nbla10317 | p100 | p110 | p200 | p75cut-like homeobox 1Reconstituted ComplexBioGRID11584018 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1Affinity Capture-WesternBioGRID10428966 
ERCC2COFS2 | EM9 | MGC102762 | MGC126218 | MGC126219 | TTD | XPDexcision repair cross-complementing rodent repair deficiency, complementation group 2-HPRD11445587 
ERCC3BTF2 | GTF2H | RAD25 | TFIIH | XPBexcision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)-HPRD,BioGRID9130708 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Biochemical ActivityBioGRID10949034 
GTF2H1BTF2 | TFB1 | TFIIHgeneral transcription factor IIH, polypeptide 1, 62kDa-HPRD,BioGRID9130708 
GTF2H2BTF2 | BTF2P44 | MGC102806 | T-BTF2P44 | TFIIHgeneral transcription factor IIH, polypeptide 2, 44kDa-HPRD9130708 
GTF2H5C6orf175 | TFB5 | TGF2H5 | TTD | TTD-A | TTDA | bA120J8.2general transcription factor IIH, polypeptide 5-HPRD,BioGRID11062469 |15220921 
HDAC2RPD3 | YAF1histone deacetylase 2Affinity Capture-WesternBioGRID12527756 
HNRNPUHNRPU | SAF-A | U21.1heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)Affinity Capture-WesternBioGRID10490622 
MCM7CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146minichromosome maintenance complex component 7-HPRD,BioGRID11056214 
MED21SRB7 | SURB7mediator complex subunit 21Affinity Capture-WesternBioGRID9315662 
MNAT1MAT1 | RNF66 | TFB3menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)-HPRD,BioGRID8521393 
-HPRD9130708 
MTA1-metastasis associated 1Affinity Capture-WesternBioGRID12527756 
RARANR1B1 | RARretinoic acid receptor, alphaRAR-alpha interacts with hMo15.BIND15249124 
TCEA1GTF2S | SII | TCEA | TF2S | TFIIStranscription elongation factor A (SII), 1Reconstituted ComplexBioGRID9305922 
THRAAR7 | EAR7 | ERB-T-1 | ERBA | ERBA1 | MGC000261 | MGC43240 | NR1A1 | THRA1 | THRA2 | c-ERBA-1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)TR-alpha interacts with hMo15. This interaction was modeled on a demonstrated interaction between chicken TR-alpha and human hMo15.BIND15249124 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Affinity Capture-Western
Biochemical Activity		BioGRID9372954 |9840937 
VDRNR1I1vitamin D (1,25- dihydroxyvitamin D3) receptorVDR interacts with hMo15.BIND15249124 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NUCLEOTIDE_EXCISION_REPAIR 4425All SZGR genes in this pathway
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
BIOCARTA_CELLCYCLE_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_PTC1_PATHWAY 116All SZGR genes in this pathway
SA_G2_AND_M_PHASES 87All SZGR genes in this pathway
PID_RETINOIC_ACID_PATHWAY 3023All SZGR genes in this pathway
REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION 2212All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_RNA_POL_I_TRANSCRIPTION 8964All SZGR genes in this pathway
REACTOME_RNA_POL_II_TRANSCRIPTION 10554All SZGR genes in this pathway
REACTOME_MRNA_CAPPING 3011All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 6540All SZGR genes in this pathway
REACTOME_G1_PHASE 3823All SZGR genes in this pathway
REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 4524All SZGR genes in this pathway
REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING 4121All SZGR genes in this pathway
REACTOME_MRNA_PROCESSING 16186All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_TRANSCRIPTION 210127All SZGR genes in this pathway
REACTOME_NUCLEOTIDE_EXCISION_REPAIR 5127All SZGR genes in this pathway
REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 4519All SZGR genes in this pathway
REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION 158All SZGR genes in this pathway
REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 3013All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 12280All SZGR genes in this pathway
REACTOME_MITOTIC_G2_G2_M_PHASES 8150All SZGR genes in this pathway
REACTOME_DNA_REPAIR 11259All SZGR genes in this pathway
REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 6132All SZGR genes in this pathway
REACTOME_GLOBAL_GENOMIC_NER_GG_NER 3520All SZGR genes in this pathway
REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 2311All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HIV_LIFE_CYCLE 12569All SZGR genes in this pathway
REACTOME_FORMATION_OF_THE_HIV1_EARLY_ELONGATION_COMPLEX 3411All SZGR genes in this pathway
REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 10461All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION 2514All SZGR genes in this pathway
PUIFFE_INVASION_INHIBITED_BY_ASCITES_DN 14591All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
HAHTOLA_SEZARY_SYNDROM_UP 9858All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_DN 229142All SZGR genes in this pathway
WANG_ESOPHAGUS_CANCER_VS_NORMAL_DN 10166All SZGR genes in this pathway
SILIGAN_TARGETS_OF_EWS_FLI1_FUSION_UP 1512All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN 8151All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
DORSAM_HOXA9_TARGETS_UP 3525All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 6348All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_UP 8961All SZGR genes in this pathway
ZHAN_V2_LATE_DIFFERENTIATION_GENES 4534All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_UP 6941All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN 9867All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D6 3725All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN 312203All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C0 10772All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1 14895All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-4961141211A,m8hsa-miR-496AUUACAUGGCCAAUCUC
hsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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