Gene Page: CDKN2A

Summary
GeneID  1029
Symbol  CDKN2A
Synonyms  ARF|CDK4I|CDKN2|CMM2|INK4|INK4a|MLM|MTS1|TP16|p14|p14ARF|p16|p16INK4|p16INK4a|p19
Description  cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
See related  HGNC:1787|MIM:600160|Ensembl:ENSG00000147889|HPRD:02542|
Locus tag  -
Gene type  protein-coding
Map location  9p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0889 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0005515protein bindingIPI11278317 |12740913 |15989956 
|17274640 |17909018 
GO:0004861cyclin-dependent protein kinase inhibitor activityIDA8259215 
GO:0051059NF-kappaB bindingIDA10353611 
GO:0019901protein kinase bindingIPI8259215 
GO:0055105ubiquitin-protein ligase inhibitor activityISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000075cell cycle checkpointIMP16243918 
GO:0000082G1/S transition of mitotic cell cycleIDA10208428 
GO:0001953negative regulation of cell-matrix adhesionIMP10205165 
GO:0006309DNA fragmentation during apoptosisIMP12082630 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0006469negative regulation of protein kinase activityIMP15582998 
GO:0006364rRNA processingIEA-
GO:0006917induction of apoptosisIDA10208428 
GO:0006917induction of apoptosisIMP12082630 
GO:0007050cell cycle arrestIMP15582998 |16243918 
GO:0008285negative regulation of cell proliferationIMP16243918 
GO:0008637apoptotic mitochondrial changesIMP12082630 
GO:0010149senescenceIMP14720514 |14966292 
GO:0048103somatic stem cell divisionISS-
GO:0010389regulation of G2/M transition of mitotic cell cycleIMP15582998 
GO:0006919caspase activationIMP12082630 
GO:0006915apoptosisIEA-
GO:0042326negative regulation of phosphorylationIDA8259215 |10208428 
GO:0033088negative regulation of immature T cell proliferation in the thymusISS-
GO:0032088negative regulation of NF-kappaB transcription factor activityIDA10353611 
GO:0030308negative regulation of cell growthIDA10208428 
GO:0031647regulation of protein stabilityISS-
GO:0030889negative regulation of B cell proliferationISS-
GO:0045736negative regulation of cyclin-dependent protein kinase activityIDA8259215 
GO:0045786negative regulation of cell cycleIEA-
GO:0051444negative regulation of ubiquitin-protein ligase activityISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA16243918 
GO:0005634nucleusIEA-
GO:0005654nucleoplasmIDA17110379 
GO:0005730nucleolusIDA17110379 
GO:0005737cytoplasmIDA16243918 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ALS2CR8CARF | DKFZp667N246 | FLJ12675 | FLJ21579 | NYD-SP24amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8-HPRD12154087 
AURKAAIK | ARK1 | AURA | AURORA2 | BTAK | MGC34538 | STK15 | STK6 | STK7aurora kinase AAffinity Capture-MSBioGRID17353931 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1Reconstituted ComplexBioGRID10580009 
CCND2KIAK0002 | MGC102758cyclin D2Reconstituted ComplexBioGRID15065884 
CCNG1CCNGcyclin G1-HPRD,BioGRID12556559 
CDK4CMM3 | MGC14458 | PSK-J3cyclin-dependent kinase 4p16 interacts with cdk4. This interaction was modeled on a demonstrated interaction between human p16 and cdk4 from an unspecified species.BIND9482104 
CDKN2A interacts with CDK4BIND11556834 
-HPRD,BioGRID9228064 
-HPRD9228064 |15232106 
p16 interacts with CDK4. This interaction was modeled on a demonstrated interaction between human p16 and CDK4 from an unspecified species.BIND10491434 
p16 interacts with cdk4.BIND8805225 
CDK6MGC59692 | PLSTIRE | STQTL11cyclin-dependent kinase 6CDKN2A interacts with CDK6BIND11556834 
p16 interacts with CDK6. This interaction was modeled on a demonstrated interaction between human p16 and CDK6 from an unspecified species.BIND10491434 
p16 interacts with cdk6. This interaction was modeled on a demonstrated interaction between human p16 and cdk6 from an unspecified species.BIND9482104 
p16 interacts with cdk6.BIND8805225 
-HPRD,BioGRID9751050 
CDKN2AIPCARF | FLJ20036CDKN2A interacting protein-HPRD12154087 
CDKN2CINK4C | p18 | p18-INK4Ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)-HPRD8259215 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1p14ARF interacts with E2F-1.BIND12082609 
E4F1E4F | MGC99614E4F transcription factor 1-HPRD,BioGRID12446718 
FKBP2FKBP-13 | PPIaseFK506 binding protein 2, 13kDaAffinity Capture-WesternBioGRID12606707 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)p14ARF interacts with HIF-1alpha.BIND11382768 
HUWE1ARF-BP1 | HECTH9 | HSPC272 | Ib772 | KIAA0312 | LASU1 | MULE | UREB1HECT, UBA and WWE domain containing 1ARF interacts with ARF-BP1.BIND15989956 
MAPK10FLJ12099 | FLJ33785 | JNK3 | JNK3A | MGC50974 | PRKM10 | p493F12 | p54bSAPKmitogen-activated protein kinase 10CDKN2A (p16INK4a) interacts with MAPK10 (JNK3)BIND16007099 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8CDKN2A (p16INK4a) interacts with MAPK8 (JNK1)BIND16007099 
MCM2BM28 | CCNL1 | CDCL1 | D3S3194 | KIAA0030 | MGC10606 | MITOTIN | cdc19minichromosome maintenance complex component 2-HPRD15232106 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)-HPRD9529248 |12085228|9529249 
p14ARF interacts with an unspecified isoform of Mdm2.BIND12582152 
Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9529248 |9529249 
|12085228 |14612427 
Mdm2 interacts with p14ARF.BIND10822382 
p14 interacts with MDM2.BIND15355988 
MDM2 interacts with p14ARFBIND9653180 
MDM4DKFZp781B1423 | HDMX | MDMX | MGC132766 | MRP1Mdm4 p53 binding protein homolog (mouse)Affinity Capture-WesternBioGRID11297540 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)p14ARF interacts with c-Myc.BIND15361884 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1NCOR1 (N-CoR) interacts with p-p14(ARF) (p14(ARF) promoter).BIND15729358 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2NCOR2 (SMRT) interacts with p-p14(ARF) (p14(ARF) promoter).BIND15729358 
PLEKHA8FAPP2 | MGC3358pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8Reconstituted ComplexBioGRID15107860 
PPP1R9BFLJ30345 | PPP1R6 | PPP1R9 | SPINO | Spnprotein phosphatase 1, regulatory (inhibitor) subunit 9B-HPRD,BioGRID11278317 
SPINO interacts with p14ARF.BIND11278317 
PSMC3MGC8487 | TBP1proteasome (prosome, macropain) 26S subunit, ATPase, 3p14ARF interacts with TBP-1.BIND14665636 
RPL11GIG34ribosomal protein L11Affinity Capture-WesternBioGRID14612427 
SERTAD1SEI1 | TRIP-Br1SERTA domain containing 1-HPRD,BioGRID10580009 |15065884 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Affinity Capture-WesternBioGRID9529249 |12446718 
|14612427 
UBE2AHHR6A | RAD6A | UBC2ubiquitin-conjugating enzyme E2A (RAD6 homolog)Affinity Capture-WesternBioGRID12640129 
WRNDKFZp686C2056 | RECQ3 | RECQL2 | RECQL3Werner syndromep14 interacts with WRN.BIND15355988 
YY1DELTA | INO80S | NF-E1 | UCRBP | YIN-YANG-1YY1 transcription factorYY1 interacts with p14ARF.BIND15210108 
ZNF410APA-1 | APA1zinc finger protein 410-HPRD12370286 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_P53_SIGNALING_PATHWAY 6945All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
KEGG_BLADDER_CANCER 4233All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA 7359All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER 5447All SZGR genes in this pathway
BIOCARTA_G1_PATHWAY 2821All SZGR genes in this pathway
BIOCARTA_CTCF_PATHWAY 2318All SZGR genes in this pathway
BIOCARTA_CELLCYCLE_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_ARF_PATHWAY 1713All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
SA_G1_AND_S_PHASES 1510All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 5141All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES 3631All SZGR genes in this pathway
SA_REG_CASCADE_OF_CYCLIN_EXPR 137All SZGR genes in this pathway
ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 3729All SZGR genes in this pathway
PID_E2F_PATHWAY 7448All SZGR genes in this pathway
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PID_FRA_PATHWAY 3728All SZGR genes in this pathway
PID_MYC_PATHWAY 2522All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_FOXM1_PATHWAY 4030All SZGR genes in this pathway
PID_HIF1A_PATHWAY 1912All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
PID_BETA_CATENIN_NUC_PATHWAY 8060All SZGR genes in this pathway
PID_DELTA_NP63_PATHWAY 4734All SZGR genes in this pathway
PID_TAP63_PATHWAY 5440All SZGR genes in this pathway
PID_P53_REGULATION_PATHWAY 5950All SZGR genes in this pathway
PID_RB_1PATHWAY 6546All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_G1_PHASE 3823All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
PYEON_HPV_POSITIVE_TUMORS_UP 9847All SZGR genes in this pathway
CORRE_MULTIPLE_MYELOMA_UP 7445All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_DN 10459All SZGR genes in this pathway
SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP 8443All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
PROVENZANI_METASTASIS_UP 194112All SZGR genes in this pathway
CASTELLANO_NRAS_TARGETS_DN 1414All SZGR genes in this pathway
CAIRO_PML_TARGETS_BOUND_BY_MYC_DN 1412All SZGR genes in this pathway
TAKADA_GASTRIC_CANCER_COPY_NUMBER_DN 2915All SZGR genes in this pathway
BUSA_SAM68_TARGETS_UP 76All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_DN 5437All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 14073All SZGR genes in this pathway
HONRADO_BREAST_CANCER_BRCA1_VS_BRCA2 1812All SZGR genes in this pathway
DAWSON_METHYLATED_IN_LYMPHOMA_TCL1 5945All SZGR genes in this pathway
OHM_METHYLATED_IN_ADULT_CANCERS 2723All SZGR genes in this pathway
OHM_EMBRYONIC_CARCINOMA_DN 86All SZGR genes in this pathway
FRIDMAN_SENESCENCE_UP 7760All SZGR genes in this pathway
FRIDMAN_IMMORTALIZATION_DN 3424All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_B 4822All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_COPY_NUMBER_DN 3121All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY 2622All SZGR genes in this pathway
SHIPP_DLBCL_CURED_VS_FATAL_DN 4530All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
TENEDINI_MEGAKARYOCYTE_MARKERS 6648All SZGR genes in this pathway
SUZUKI_RESPONSE_TO_TSA_AND_DECITABINE_1A 2316All SZGR genes in this pathway
SATO_SILENCED_EPIGENETICALLY_IN_PANCREATIC_CANCER 4930All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C3 3624All SZGR genes in this pathway
BURTON_ADIPOGENESIS_9 9259All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_UP 2720All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_DN 2826All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
LIN_MELANOMA_COPY_NUMBER_DN 4134All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN 228114All SZGR genes in this pathway
HOQUE_METHYLATED_IN_CANCER 5645All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_DN 4031All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 298174All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
MIKKELSEN_PARTIALLY_REPROGRAMMED_TO_PLURIPOTENCY 106All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_DN 7651All SZGR genes in this pathway
LI_PROSTATE_CANCER_EPIGENETIC 3022All SZGR genes in this pathway
PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP 19395All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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