Gene Page: IKZF1

Summary
GeneID  10320
Symbol  IKZF1
Synonyms  Hs.54452|IK1|IKAROS|LYF1|PRO0758|ZNFN1A1|hIk-1
Description  IKAROS family zinc finger 1 (Ikaros)
See related  HGNC:13176|MIM:603023|Ensembl:ENSG00000185811|HPRD:04318|
Locus tag  -
Gene type  protein-coding
Map location  7p13-p11.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NDUFA20.930.83
MRPL540.920.83
NDUFB70.910.81
C19orf700.910.78
NDUFA110.910.87
UQCRQ0.900.80
UQCR0.900.77
ZNF5930.900.71
LSMD10.890.76
AC009171.10.890.80
Top 10 negatively co-expressed genes
KIF16B-0.49-0.55
CCDC55-0.48-0.52
MYH9-0.47-0.46
GOLGB1-0.47-0.48
GOLGA4-0.46-0.48
BAT2D1-0.46-0.45
FNBP1-0.46-0.52
MPHOSPH8-0.46-0.44
Z83840.4-0.45-0.58
DST-0.45-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0005515protein bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0016564transcription repressor activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007498mesoderm developmentTAS8543809 
GO:0016481negative regulation of transcriptionIEA-
GO:0040018positive regulation of multicellular organism growthIEA-
GO:0048732gland developmentIEA-
GO:0030097hemopoiesisIEA-
GO:0045941positive regulation of transcriptionIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005721centromeric heterochromatinIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2M1AP50 | CLAPM1 | mu2adaptor-related protein complex 2, mu 1 subunitTwo-hybridBioGRID16189514 
CHD3Mi-2a | Mi2-ALPHA | ZFHchromodomain helicase DNA binding protein 3-HPRD10204490 
CHD4DKFZp686E06161 | Mi-2b | Mi2-BETAchromodomain helicase DNA binding protein 4Affinity Capture-WesternBioGRID12015313 
CTBP1BARS | MGC104684C-terminal binding protein 1-HPRD,BioGRID10766745 
GTF2BTF2B | TFIIBgeneral transcription factor IIBReconstituted ComplexBioGRID11959865 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Affinity Capture-WesternBioGRID10357820 |12015313 
HDAC2RPD3 | YAF1histone deacetylase 2Affinity Capture-WesternBioGRID12015313 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3Affinity Capture-WesternBioGRID12015313 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4Affinity Capture-WesternBioGRID12015313 
HDAC5FLJ90614 | HD5 | NY-CO-9histone deacetylase 5Affinity Capture-WesternBioGRID12015313 
HDAC7DKFZp586J0917 | FLJ99588 | HD7A | HDAC7Ahistone deacetylase 7Affinity Capture-WesternBioGRID12015313 
IKZF2HELIOS | MGC34330 | ZNF1A2 | ZNFN1A2IKAROS family zinc finger 2 (Helios)-HPRD,BioGRID9560339 
IKZF3AIO | AIOLOS | ZNFN1A3IKAROS family zinc finger 3 (Aiolos)-HPRD9155026 
IKZF4EOS | KIAA1782 | ZNFN1A4IKAROS family zinc finger 4 (Eos)-HPRD,BioGRID10218586 |10978333 
IKZF5DKFZp781B0249 | FLJ22973 | PEGASUS | ZNFN1A5IKAROS family zinc finger 5 (Pegasus)Reconstituted Complex
Two-hybrid		BioGRID10978333 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2Affinity Capture-WesternBioGRID11959865 
RBBP8CTIP | RIMretinoblastoma binding protein 8-HPRD,BioGRID11959865 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)Affinity Capture-WesternBioGRID10357820 |11959865 
|12015313 
-HPRD10357820 |12015313 
SIN3BKIAA0700SIN3 homolog B, transcription regulator (yeast)-HPRD,BioGRID10357820 |12015313 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding protein-HPRD,BioGRID11959865 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_NFAT_TFPATHWAY 4739All SZGR genes in this pathway
WINTER_HYPOXIA_DN 5230All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP 175108All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
MAYBURD_RESPONSE_TO_L663536_UP 2918All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_DN 1610All SZGR genes in this pathway
KLEIN_TARGETS_OF_BCR_ABL1_FUSION 4534All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_6 8454All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_29 117All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
GOERING_BLOOD_HDL_CHOLESTEROL_QTL_CIS 137All SZGR genes in this pathway
BYSTROEM_CORRELATED_WITH_IL5_DN 6447All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_UP 8767All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_2G 17196All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP 194133All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE 15186All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-128347634831A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-137332233281Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-153350535111Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-21845521A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-25/32/92/363/367350735131Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-27347734841A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-448350435111A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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