Gene Page: SORBS1

Summary
GeneID  10580
Symbol  SORBS1
Synonyms  CAP|DKFZp451C066|DKFZp586P1422|FLAF2|FLJ12406|KIAA1296|R85FL|SH3D5|SH3P12|SORB1
Description  sorbin and SH3 domain containing 1
See related  HGNC:14565|MIM:605264|Ensembl:ENSG00000095637|HPRD:05587|
Locus tag  -
Gene type  protein-coding
Map location  10q23.3-q24.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RFPL3S0.710.67
PDIA20.600.61
HSF40.600.63
RFPL20.600.56
NOXA10.590.58
NFKBID0.590.58
SLC25A280.590.64
AL008723.60.570.54
GALT0.560.59
AL117190.40.560.70
Top 10 negatively co-expressed genes
CD248-0.32-0.38
SLC38A5-0.30-0.33
KDR-0.29-0.29
CD93-0.29-0.32
IPMK-0.28-0.18
C10orf47-0.28-0.30
STRA6-0.28-0.28
KBTBD6-0.28-0.16
CTDSPL2-0.28-0.16
SERBP1-0.27-0.18
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingTAS10085297 
GO:0005158insulin receptor bindingIDA11374898 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008286insulin receptor signaling pathwayISS-
GO:0048041focal adhesion formationISS-
GO:0015758glucose transportISS-
GO:0006810transportIEA-
GO:0043149stress fiber formationISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001725stress fiberISS-
GO:0005856cytoskeletonIEA-
GO:0005634nucleusIDA11371513 
GO:0005737cytoplasmIEA-
GO:0005915zonula adherensTAS10085297 
GO:0005924cell-substrate adherens junctionISS-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
GO:0045121membrane raftISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID11374898 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD11001060 
Affinity Capture-WesternBioGRID12504111 |15128873 
An unspecified isoform of CAP interacts with Cbl. This interaction was modeled on a demonstrated interaction between CAP from an unspecified species and human Cbl.BIND15128873 
EFNB1CFND | CFNS | EFL3 | EPLG2 | Elk-L | LERK2 | MGC8782ephrin-B1-HPRD11557983 
EIF62 | CAB | EIF3A | ITGB4BP | b | b(2)gcn | gcn | p27BBPeukaryotic translation initiation factor 6Affinity Capture-MSBioGRID17353931 
FLOT1-flotillin 1CAP interacts with flotillin-1. This interaction was modeled on a demonstrated interaction between CAP and flotillin-1 both from an unspecified species.BIND15128873 
-HPRD,BioGRID11481476 
INPPL1SHIP2inositol polyphosphate phosphatase-like 1-HPRD,BioGRID12504111 
INSM1IA-1 | IA1insulinoma-associated 1-HPRD,BioGRID12079283 
INSRCD220 | HHF5insulin receptor-HPRD,BioGRID11374898 
MLLT4AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4-HPRD,BioGRID10085297 |10583506 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD9461600 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 betaAffinity Capture-WesternBioGRID15128873 
VCLCMD1W | MVCLvinculin-HPRD,BioGRID10085297 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PPAR_SIGNALING_PATHWAY 6947All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 5141All SZGR genes in this pathway
PID_INSULIN_PATHWAY 4532All SZGR genes in this pathway
REACTOME_MUSCLE_CONTRACTION 4824All SZGR genes in this pathway
REACTOME_SMOOTH_MUSCLE_CONTRACTION 2514All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_DN 6943All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP 14699All SZGR genes in this pathway
LANDIS_BREAST_CANCER_PROGRESSION_DN 7043All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_REVERSIBLY_DN 2921All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_DN 14993All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP 197135All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_6 8454All SZGR genes in this pathway
LA_MEN1_TARGETS 2415All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_UP 5030All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN 12179All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
GOLDRATH_IMMUNE_MEMORY 6542All SZGR genes in this pathway
RUAN_RESPONSE_TO_TROGLITAZONE_UP 2515All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_UP 3823All SZGR genes in this pathway
RUAN_RESPONSE_TO_TNF_DN 8450All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BURTON_ADIPOGENESIS_5 12678All SZGR genes in this pathway
NIELSEN_LEIOMYOSARCOMA_CNN1_UP 1913All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP 221150All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
ZHANG_TLX_TARGETS_UP 10878All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB 14583All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_DN 242146All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
GOBERT_CORE_OLIGODENDROCYTE_DIFFERENTIATION 4028All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_UP 13596All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN 9974All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-142-5p32643270m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-205283928461A,m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-21618241Ahsa-miR-216UAAUCUCAGCUGGCAACUGUG
miR-218287528811Ahsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-381275927661A,m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-433-3p50561Ahsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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