Gene Page: ADCYAP1

Summary
GeneID  116
Symbol  ADCYAP1
Synonyms  MGC126852|PACAP
Description  adenylate cyclase activating polypeptide 1 (pituitary)
See related  HGNC:241|MIM:102980|Ensembl:ENSG00000141433|HPRD:02369|
Locus tag  -
Gene type  protein-coding
Map location  18p11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DTX40.970.96
SRGAP20.950.97
RALGPS10.950.96
TRIO0.950.97
DYRK20.940.96
ATXN7L10.940.96
FAM123B0.940.95
CDK5R10.940.96
KDM2B0.940.96
CLASP10.930.96
Top 10 negatively co-expressed genes
HEPN1-0.74-0.82
AIFM3-0.73-0.82
TSC22D4-0.73-0.84
SERPINB6-0.73-0.80
S100B-0.72-0.88
HSD17B14-0.72-0.84
AF347015.31-0.72-0.91
FXYD1-0.71-0.89
HLA-F-0.71-0.79
ALDOC-0.71-0.75
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005184neuropeptide hormone activityTASaxon, Synap, Brain, Neurotransmitter (GO term level: 6)2302217 
GO:0005057receptor signaling protein activityIEA-
GO:0005179hormone activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007190activation of adenylate cyclase activityEXP16805430 
GO:0007190activation of adenylate cyclase activityTAS1730060 
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayEXP16939974 
GO:0007267cell-cell signalingTAS2302217 
GO:0007565female pregnancyTAS10698193 
GO:0045786negative regulation of cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005625soluble fractionTAS10698193 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADCYAP1R1PAC1 | PACAPR | PACAPRIadenylate cyclase activating polypeptide 1 (pituitary) receptor type I-HPRD8253796 |10583729 
CPAMD8FLJ42058 | FLJ90618 | K-CAP | KIAA1283 | VIPC3 and PZP-like, alpha-2-macroglobulin domain containing 8Protein-peptideBioGRID1335692 
SCTRSRsecretin receptorProtein-peptideBioGRID1335692 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS 8858All SZGR genes in this pathway
REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS 3322All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
GRABARCZYK_BCL11B_TARGETS_UP 8140All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP 15791All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_D_UP 3823All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_UP 8767All SZGR genes in this pathway
MCCLUNG_DELTA_FOSB_TARGETS_2WK 4836All SZGR genes in this pathway
MA_PITUITARY_FETAL_VS_ADULT_UP 2921All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN 9867All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_UP 10072All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_WITHOUT_MGMT_48HR_DN 3225All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_DN 10864All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MIKKELSEN_IPS_HCP_WITH_H3_UNMETHYLATED 8050All SZGR genes in this pathway
LOPEZ_EPITHELIOID_MESOTHELIOMA 1711All SZGR genes in this pathway
MIKKELSEN_ES_HCP_WITH_H3K27ME3 4130All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1332002061Ahsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-135121127m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-3624014071Ahsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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