Gene Page: CRK

Summary
GeneID  1398
Symbol  CRK
Synonyms  CRKII
Description  v-crk sarcoma virus CT10 oncogene homolog (avian)
See related  HGNC:2362|MIM:164762|Ensembl:ENSG00000167193|HPRD:01267|
Locus tag  -
Gene type  protein-coding
Map location  17p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4103 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SLC39A60.950.95
EIF4G20.940.95
XRCC50.940.95
WDR40A0.940.93
GPN10.940.93
HSDL10.930.95
GART0.930.94
PTBP20.930.95
YWHAQ0.930.92
C10orf1190.920.92
Top 10 negatively co-expressed genes
AF347015.27-0.74-0.88
AF347015.31-0.74-0.89
MT-CO2-0.74-0.91
AF347015.33-0.73-0.87
C5orf53-0.72-0.74
MT-CYB-0.72-0.88
FXYD1-0.72-0.86
AF347015.8-0.71-0.90
HLA-F-0.71-0.75
AIFM3-0.70-0.74
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI9788432 |9819391 |11278465 
|14657239 |15886098 
|16713569 
GO:0042169SH2 domain bindingIPI9472046 
GO:0045309protein phosphorylated amino acid bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006357regulation of transcription from RNA polymerase II promoterTAS10748058 
GO:0007242intracellular signaling cascadeEXP9069267 
GO:0030036actin cytoskeleton organizationTAS10748058 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP16284401 
GO:0005634nucleusTAS10748058 
GO:0005737cytoplasmTAS10748058 
GO:0005768endosomeEXP7806500 
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinasec-Abl interacts with Crk. This interaction was modeled on a demonstrated interaction between human c-Abl and Crk from an unspecified species.BIND15696159 
Interaction between ABL (PDB ID: 1JU5_C) and CRK (PDB ID: 1JU5_A).BIND12384576 
ABL2ABLL | ARG | FLJ22224 | FLJ31718 | FLJ41441v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)Abl2 phosphorylates CRK. This interaction was modeled on a demonstrated interaction between ABL2 from an unspecified species and human CRK.BIND15886098 
-HPRD8875975 
ABL2 (Arg) phosphorylates CRK.BIND15735735 
ARHGAP17DKFZp564A1363 | FLJ37567 | FLJ43368 | MGC87805 | MST066 | MST110 | MSTP038 | MSTP066 | MSTP110 | NADRIN | RICH1 | WBP15Rho GTPase activating protein 17Reconstituted ComplexBioGRID11431473 
ASAP1AMAP1 | CENTB4 | DDEF1 | KIAA1249 | PAG2 | PAP | ZG14PArfGAP with SH3 domain, ankyrin repeat and PH domain 1Reconstituted ComplexBioGRID9819391 
DDEF1 (AMAP1) interacts with an unspecified isoform of CRK (Crk II).BIND15719014 
AVILADVIL | DKFZp779O1812 | DOC6 | FLJ12386 | MGC133244 | p92advillin-HPRD,BioGRID11287316 
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1Affinity Capture-Western
Reconstituted Complex		BioGRID9581808 |9920935 
|10085298 |10329689 
|11369773 |12615911 
|14657239 |15492270 
BUB1BUB1A | BUB1L | hBUB1budding uninhibited by benzimidazoles 1 homolog (yeast)Two-hybridBioGRID16189514 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequenceAffinity Capture-WesternBioGRID9178909 |9461587 
-HPRD8621483 |8662998 
CBLCCBL-3 | CBL-SL | RNF57Cas-Br-M (murine) ecotropic retroviral transforming sequence c-HPRD,BioGRID10362357 
-HPRD10362357 |10571044 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD9614078 
DAB1-disabled homolog 1 (Drosophila)-HPRD15062102 
DOCK1DOCK180 | ced5dedicator of cytokinesis 1Affinity Capture-Western
Co-fractionation
Reconstituted Complex		BioGRID8657152 |8662907 
|10559471 |11369773 
|12615911 
-HPRD8657152|11369773 
DOCK3KIAA0299 | MOCA | PBPdedicator of cytokinesis 3-HPRD10854253 
DOK4FLJ10488docking protein 4-HPRD12730241 
IRS5/DOK4 interacts with Crk. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Crk.BIND12730241 
DPPA42410091M23Rik | FLJ10713developmental pluripotency associated 4Two-hybridBioGRID16189514 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID9642287 
EPHA3ETK | ETK1 | HEK | HEK4 | TYRO4EPH receptor A3-HPRD,BioGRID11870224 
EPHB2CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5EPH receptor B2Reconstituted ComplexBioGRID10644995 
EPHB3ETK2 | HEK2 | TYRO6EPH receptor B3-HPRD,BioGRID9674711 
EPS15AF-1P | AF1P | MLLT5epidermal growth factor receptor pathway substrate 15-HPRD,BioGRID7797522 
ERBB4HER4 | MGC138404 | p180erbB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)Affinity Capture-MSBioGRID16729043 
FRS2FRS2A | FRS2alpha | SNT | SNT-1 | SNT1fibroblast growth factor receptor substrate 2Reconstituted ComplexBioGRID10092678 
GAB1-GRB2-associated binding protein 1-HPRD12138161 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-Western
Far Western
Reconstituted Complex		BioGRID8662907 |8810325 
|10970810 
-HPRD8662907 |10970810 
IRS4IRS-4 | PY160insulin receptor substrate 4-HPRD,BioGRID9614078 |11316748 
KCNIP3CSEN | DREAM | KCHIP3 | MGC18289Kv channel interacting protein 3, calsenilinAffinity Capture-WesternBioGRID10854253 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1Reconstituted ComplexBioGRID1545818 
MAP4K1HPK1mitogen-activated protein kinase kinase kinase kinase 1HPK1, a Ste-20 homologous serine/threonine kinase phosphorylates Crk, an adaptor protein.BIND9891069 
-HPRD9891069 |11432831 
Affinity Capture-Western
Reconstituted Complex		BioGRID9788432 |9891069 
MAP4K5GCKR | KHS | KHS1 | MAPKKKK5mitogen-activated protein kinase kinase kinase kinase 5-HPRD,BioGRID10648385 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8-HPRD,BioGRID11432831 
MICAL1DKFZp434B1517 | FLJ11937 | FLJ21739 | MICAL | MICAL-1 | NICALmicrotubule associated monoxygenase, calponin and LIM domain containing 1Reconstituted ComplexBioGRID11827972 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1Reconstituted ComplexBioGRID8879209 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9-HPRD8879209 |9366405 
|9497377 
Affinity Capture-Western
Reconstituted Complex		BioGRID8879209 |9497377 
PDGFRACD140A | MGC74795 | PDGFR2 | Rhe-PDGFRAplatelet-derived growth factor receptor, alpha polypeptide-HPRD,BioGRID9546424 |10733900 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptidePDGFR interacts with Crk. This interaction was modelled on a demonstrated interaction between rat PDGFR and Crk from an unknown species.BIND2173144 
-HPRD,BioGRID10733900 
PLSCR1MMTRA1Bphospholipid scramblase 1Two-hybridBioGRID16189514 
PSMC6CADP44 | MGC12520 | P44 | SUG2 | p42proteasome (prosome, macropain) 26S subunit, ATPase, 6Two-hybridBioGRID16189514 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2Affinity Capture-Western
Reconstituted Complex		BioGRID10085298 |12615911 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD10329689 
PTPN1PTP1Bprotein tyrosine phosphatase, non-receptor type 1Reconstituted ComplexBioGRID8940134 
PXNFLJ16691paxillin-HPRD,BioGRID12198159 
RAPGEF1C3G | DKFZp781P1719 | GRF2Rap guanine nucleotide exchange factor (GEF) 1-HPRD7512734|11870224 |12054111 
-HPRD,BioGRID7512734 |8621483 
|11870224 |12054111 
RETCDHF12 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1 | RET51ret proto-oncogeneReconstituted ComplexBioGRID9393871 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating proteinCrk interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Crk from an unspecified species and human GC-GAP.BIND12819203 
Affinity Capture-Western
Reconstituted Complex		BioGRID12454018 |12819203 
-HPRD12446789 |12454018 
SH3BP1-SH3-domain binding protein 1-HPRD,BioGRID1379745 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1Affinity Capture-WesternBioGRID11071869 
SHBRP11-3J10.8 | bA3J10.2Src homology 2 domain containing adaptor protein B-HPRD,BioGRID10964504 
SNIPKIAA1684SNAP25-interacting protein-HPRD,BioGRID14657239 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1Reconstituted ComplexBioGRID10022833 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD,BioGRID8810325 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Affinity Capture-WesternBioGRID12615911 
SYN1SYN1a | SYN1b | SYNIsynapsin I-HPRD,BioGRID10899172 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD8621483 
VAV2-vav 2 guanine nucleotide exchange factorCrk interacts with Vav.BIND8621483 
WEE1DKFZp686I18166 | FLJ16446 | WEE1A | WEE1huWEE1 homolog (S. pombe)-HPRD,BioGRID11839808 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)-HPRD,BioGRID11839808 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDa-HPRD,BioGRID10419455 
ZAP-70 interacts with Crk-I.BIND10419455 
ZAP-70 interacts with Crk-II.BIND10419455 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA 7359All SZGR genes in this pathway
BIOCARTA_CXCR4_PATHWAY 2422All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY 3730All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY 6352All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
PID_INSULIN_PATHWAY 4532All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
PID_NECTIN_PATHWAY 3020All SZGR genes in this pathway
PID_RET_PATHWAY 3929All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_IGF1_PATHWAY 3023All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY 3933All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY 4230All SZGR genes in this pathway
PID_EPHA_FWDPATHWAY 3429All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
PID_TCR_JNK_PATHWAY 1411All SZGR genes in this pathway
PID_PDGFRA_PATHWAY 2218All SZGR genes in this pathway
PID_LYMPH_ANGIOGENESIS_PATHWAY 2516All SZGR genes in this pathway
PID_INTEGRIN_A4B1_PATHWAY 3324All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_ARMS_MEDIATED_ACTIVATION 1717All SZGR genes in this pathway
REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS 1918All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS 3630All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS 1511All SZGR genes in this pathway
REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING 2717All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_REGULATION_OF_SIGNALING_BY_CBL 1816All SZGR genes in this pathway
REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 4334All SZGR genes in this pathway
REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 3623All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_SIGNAL_ATTENUATION 148All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
WANG_CLIM2_TARGETS_DN 186114All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP 214144All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_DN 13797All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP 197135All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_UP 181108All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
GEORGES_CELL_CYCLE_MIR192_TARGETS 6246All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
STONER_ESOPHAGEAL_CARCINOGENESIS_UP 3925All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2066646701Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-101751811Ahsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-126/126-3p1781841Ahsa-miR-126brainUCGUACCGUGAGUAAUAAUGC
miR-1339139191Ahsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-142-3p536542m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-142-5p695701m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-15194100m8hsa-miR-151brainACUAGACUGAAGCUCCUUGAGG
miR-17-5p/20/93.mr/106/519.d6937001A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-186591597m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-3207117171Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-3255395461A,m8hsa-miR-325CCUAGUAGGUGUCCAGUAAGUGU
miR-3774434491Ahsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-3819819881A,m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-4101021081Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-93.hd/291-3p/294/295/302/372/373/520692698m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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