Gene Page: ADRA1B

Summary
GeneID  147
Symbol  ADRA1B
Synonyms  ADRA1|ALPHA1BAR
Description  adrenergic, alpha-1B-, receptor
See related  HGNC:278|MIM:104220|Ensembl:ENSG00000170214|HPRD:00080|
Locus tag  -
Gene type  protein-coding
Map location  5q23-q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0483 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MN10.910.89
SOBP0.900.94
MPPED10.890.92
SCUBE10.880.81
SLA0.880.88
TTC280.880.87
SATB20.880.90
NHSL10.870.70
SLC22A230.870.87
MYCN0.870.89
Top 10 negatively co-expressed genes
SERPINB6-0.60-0.76
ACOT13-0.57-0.67
HEPN1-0.57-0.74
AIFM3-0.57-0.74
HSD17B14-0.57-0.77
C5orf53-0.57-0.72
HLA-F-0.56-0.73
ALDOC-0.56-0.67
CLU-0.56-0.68
TSC22D4-0.56-0.76
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004937alpha1-adrenergic receptor activityTAS1328250 
GO:0004935adrenoceptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001987vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressureIEA-
GO:0001996positive regulation of heart rate by epinephrine-norepinephrineIEA-
GO:0001997positive regulation of the force of heart contraction by epinephrine-norepinephrineIEA-
GO:0001975response to amphetamineIEA-
GO:0001974blood vessel remodelingIEA-
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerTAS10820200 
GO:0007186G-protein coupled receptor protein signaling pathwayTAS2154750 
GO:0016049cell growthIEA-
GO:0007267cell-cell signalingTAS1328250 
GO:0007243protein kinase cascadeTAS10820200 
GO:0007165signal transductionIEA-
GO:0008283cell proliferationTAS10820200 
GO:0008542visual learningIEA-
GO:0007512adult heart developmentIEA-
GO:0007626locomotory behaviorIEA-
GO:0007275multicellular organismal developmentTAS10820200 
GO:0042593glucose homeostasisIEA-
GO:0035265organ growthIEA-
GO:0043278response to morphineIEA-
GO:0048148behavioral response to cocaineIEA-
GO:0045819positive regulation of glycogen catabolic processIEA-
GO:0045818negative regulation of glycogen catabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000299integral to membrane of membrane fractionIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS1328250 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2M1AP50 | CLAPM1 | mu2adaptor-related protein complex 2, mu 1 subunitAffinity Capture-Western
Two-hybrid		BioGRID12644451 
GNA11GNA-11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)-HPRD9481484 
SAGARRESTIN | DKFZp686D1084 | DKFZp686I1383 | S-AGS-antigen; retina and pineal gland (arrestin)-HPRD8617782 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD10652206 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS 3833All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 7456All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
PETRETTO_HEART_MASS_QTL_CIS_UP 2815All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_24HR_DN 3321All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_WITHOUT_MGMT_48HR_DN 3225All SZGR genes in this pathway
SEMENZA_HIF1_TARGETS 3632All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
DANG_MYC_TARGETS_UP 143100All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
OHGUCHI_LIVER_HNF4A_TARGETS_DN 14985All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_UP 221120All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-22141147m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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