Gene Page: CTNNB1

Summary
GeneID  1499
Symbol  CTNNB1
Synonyms  CTNNB|DKFZp686D02253|FLJ25606|FLJ37923
Description  catenin (cadherin-associated protein), beta 1, 88kDa
See related  HGNC:2514|MIM:116806|Ensembl:ENSG00000168036|HPRD:00286|
Locus tag  -
Gene type  protein-coding
Map location  3p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.9379 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityNAS10192393 
GO:0003713transcription coactivator activityNAS15572661 
GO:0005198structural molecule activityIEA-
GO:0008022protein C-terminus bindingIPI10773885 
GO:0050681androgen receptor bindingNAS15572661 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001837epithelial to mesenchymal transitionTAS14679171 
GO:0007155cell adhesionIEA-
GO:0006350transcriptionIEA-
GO:0030521androgen receptor signaling pathwayNAS15572661 
GO:0045893positive regulation of transcription, DNA-dependentNAS15572661 
GO:0060070Wnt receptor signaling pathway through beta-cateninIC9601641 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP11955436 |12000790 |12820959 
|15327769 |16753179 
GO:0005856cytoskeletonTAS7806582 
GO:0005634nucleusTAS9065401 
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneTAS10837025 
GO:0016328lateral plasma membraneIDA12072559 
GO:0030877beta-catenin destruction complexIDA9601641 |16188939 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACP1HAAP | MGC111030 | MGC3499acid phosphatase 1, soluble-HPRD,BioGRID12438242 
AJAP1MOT8 | RP3-426F10.1 | SHREW-1 | SHREW1adherens junctions associated protein 1-HPRD,BioGRID14595118 
APCBTPS2 | DP2 | DP2.5 | DP3 | GSadenomatous polyposis coliAPC interacts with Beta-catenin.BIND15525529 
-HPRD12000790 
Beta-catenin interacts with APC. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse Apc.BIND15294866 
Affinity Capture-Western
Co-crystal Structure
Far Western
Reconstituted Complex
BioGRID8259519 |9286858 
|11251183 |11533658 
|11707392 |11712088 
|11972058 |12628243 
APC2APCLadenomatosis polyposis coli 2-HPRD,BioGRID9823329 |10021369 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID11916967 
ARHGEF4ASEF | ASEF1 | GEF4 | STM6Rho guanine nucleotide exchange factor (GEF) 4-HPRD10947987 
AXIN1AXIN | MGC52315axin 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID9734785 |12805222 
-HPRD12000790 
AXIN2AXIL | DKFZp781B0869 | MGC10366 | MGC126582axin 2-HPRD,BioGRID10966653 
beta-catenin interacts with the Axin2 promoter.BIND15304487 
BCL3BCL4 | D19S37B-cell CLL/lymphoma 3CTNNB1 (beta-catenin) interacts with BCL3.BIND15829968 
BCL9LGS | MGC131591B-cell CLL/lymphoma 9Beta-catenin interacts with LGS1.BIND15294866 
BOC-Boc homolog (mouse)-HPRD,BioGRID12634428 
BTRCBETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCPbeta-transducin repeat containing-HPRD11818547 |12114015 
BTRC (Beta-TrCP1) interacts with CTNNB1 (Beta-catenin).BIND15735746 
CA9CAIX | MNcarbonic anhydrase IX-HPRD,BioGRID14567991 
CACYBPGIG5 | MGC87971 | PNAS-107 | RP1-102G20.6 | S100A6BP | SIPcalcyclin binding proteinAffinity Capture-WesternBioGRID11389839 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidase-HPRD9348292 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD12189238 
CBY1C22orf2 | CBY | HS508I15A | PGEA1 | PIGEA-14 | PIGEA14 | arb1chibby homolog 1 (Drosophila)-HPRD,BioGRID12712206 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1CTNNB1 (beta-catenin) interacts with the CCND1 promoter.BIND15592430 
-HPRD11836555 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 moleculeCTNNB1 (beta-catenin) interacts with the CD82 (KAI1) promoter.BIND15829968 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)Affinity Capture-Western
Co-crystal Structure
BioGRID7542250 |7876318 
|7954478 |8227214 
|9233779 |9405455 
|9535896 |9819408 
|10381631 |10772923 
|11113628 |11245482 
|11254878 |11348595 
|11712088 |11960376 
|12061792 |12169098 
|12634428 |12640114 
|12830000 |15023525 
-HPRD9512503 
Beta-catenin interacts with E-cadherin. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse E-cadherin.BIND15294866 
E-cadherin interacts with beta-catenin.BIND14706341 
Beta-catenin interacts with E-cadherin. This interaction was modelled on a demonstrated interaction between beta-catenin from an unspecified species and human E-cadherin.BIND15542433 
CDH10-cadherin 10, type 2 (T2-cadherin)Affinity Capture-WesternBioGRID10861224 
CDH11CAD11 | CDHOB | OB | OSF-4cadherin 11, type 2, OB-cadherin (osteoblast)-HPRD,BioGRID10029089 
CDH15CDH14 | CDH3 | CDHM | MCADcadherin 15, type 1, M-cadherin (myotubule)-HPRD9545347 
CDH16-cadherin 16, KSP-cadherin-HPRD15023525 
CDH17CDH16 | FLJ26931 | HPT-1 | HPT1 | MGC138218 | MGC142024cadherin 17, LI cadherin (liver-intestine)Affinity Capture-WesternBioGRID15023525 
CDH18CDH14 | CDH14L | CDH24 | EY-CADHERINcadherin 18, type 2Affinity Capture-WesternBioGRID10207020 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)Affinity Capture-MS
Affinity Capture-Western
BioGRID12604612 |14625392 
-HPRD12151522 
CDH24CDH11L | FLJ25193 | MGC131880cadherin-like 24-HPRD12734196 
CDH3CDHP | HJMD | PCADcadherin 3, type 1, P-cadherin (placental)-HPRD8227214 |10381631 
|11889072 |12800191 
Affinity Capture-Western
Co-purification
BioGRID10381631 |10910767 
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)-HPRD12413882 
Affinity Capture-WesternBioGRID9434630 |12003790 
CDH6KCADcadherin 6, type 2, K-cadherin (fetal kidney)Affinity Capture-WesternBioGRID10207020 
CDH7CDH7L1cadherin 7, type 2-HPRD,BioGRID10861224 
CDH8Nbla04261cadherin 8, type 2-HPRD,BioGRID9521872 
CDH9MGC125386cadherin 9, type 2 (T1-cadherin)-HPRD,BioGRID10861224 
CDK5PSSALREcyclin-dependent kinase 5-HPRD11168528 
CDK5R1CDK5P35 | CDK5R | MGC33831 | NCK5A | p23 | p25 | p35 | p35nck5acyclin-dependent kinase 5, regulatory subunit 1 (p35)Affinity Capture-Western
Reconstituted Complex
BioGRID11168528 
CDONCDO | MGC111524 | ORCAMCdon homolog (mouse)-HPRD,BioGRID12634428 
CEBPAC/EBP-alpha | CEBPCCAAT/enhancer binding protein (C/EBP), alpha-HPRD,BioGRID12861022 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinase-HPRD,BioGRID11527961 
CREBBPCBP | KAT3A | RSTSCREB binding proteinPhenotypic EnhancementBioGRID15782138 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD12432063 
CTNNA1CAP102 | FLJ36832catenin (cadherin-associated protein), alpha 1, 102kDa-HPRD,BioGRID7706414 
Beta-catenin interacts with alpha-catenin. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse alpha-catenin.BIND15294866 
CTNNA3MGC26194 | MGC75041 | VR22catenin (cadherin-associated protein), alpha 3-HPRD,BioGRID11590244 
CTNNBIP1ICAT | MGC15093catenin, beta interacting protein 1-HPRD,BioGRID10898789 
CTNND1CAS | CTNND | KIAA0384 | P120CAS | P120CTN | p120catenin (cadherin-associated protein), delta 1Affinity Capture-WesternBioGRID9535896 |11712088 
DKK1DKK-1 | SKdickkopf homolog 1 (Xenopus laevis)CTNNB1 (beta-catenin) interacts with the DKK1 promoter.BIND15592430 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD9512503 
DLG5KIAA0583 | LP-DLG | P-DLG5 | PDLGdiscs, large homolog 5 (Drosophila)-HPRD,BioGRID12657639 
DLGAP1DAP-1 | DAP-1-ALPHA | DAP-1-BETA | GKAP | MGC88156 | SAPAP1 | hGKAPdiscs, large (Drosophila) homolog-associated protein 1Affinity Capture-WesternBioGRID9286858 
DSC3CDHF3 | DSC | DSC1 | DSC2 | DSC4 | HT-CPdesmocollin 3-HPRD,BioGRID10769211 
DVL1DVL | MGC54245dishevelled, dsh homolog 1 (Drosophila)-HPRD,BioGRID10806215 
DVL2-dishevelled, dsh homolog 2 (Drosophila)Affinity Capture-WesternBioGRID10806215 
DVL3KIAA0208dishevelled, dsh homolog 3 (Drosophila)-HPRD,BioGRID10806215 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID9233779 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD,BioGRID7702605 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Affinity Capture-WesternBioGRID15304487 
beta-catenin interacts with ER-alpha.BIND15304487 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrin-HPRD,BioGRID10462524 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)CTNNB1 (beta-catenin) interacts with the FAS promoter.BIND15829968 
FERTYK3fer (fps/fes related) tyrosine kinaseBiochemical ActivityBioGRID12640114 
FGF20-fibroblast growth factor 20CTNNB1 (beta-catenin) interacts with the FGF20 promoter.BIND15592430 
FHL2AAG11 | DRAL | SLIM3four and a half LIM domains 2-HPRD,BioGRID12466281 
FOXO1FKH1 | FKHR | FOXO1Aforkhead box O1beta-catenin interacts with FOXO1. This interaction was modelled on a demonstrated interaction between beta-catenin from an unspecified species and human FOXO1.BIND15905404 
FOXO3AF6q21 | DKFZp781A0677 | FKHRL1 | FKHRL1P2 | FOXO2 | FOXO3A | MGC12739 | MGC31925forkhead box O3beta-catenin interacts with FOXO3a.BIND15905404 
FOXO4AFX | AFX1 | MGC120490 | MLLT7forkhead box O4beta-catenin interacts with FOXO4. This interaction was modelled on a demonstrated interaction between human FOXO4 and beta-catenin from an unspecified species.BIND15905404 
FSCN2RFSN | RP30fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)-HPRD11795941 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YESBiochemical ActivityBioGRID12640114 
GNA13G13 | MGC46138guanine nucleotide binding protein (G protein), alpha 13-HPRD11136230 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2-HPRD12151522 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD10862698 
GSK3B-glycogen synthase kinase 3 betaGSK3B (GSK3-Beta) interacts with and phosphorylates CTNNB1 (Beta-catenin).BIND15829978 
Affinity Capture-Western
Biochemical Activity
BioGRID10330181 |11251183 
HNF1AHNF1 | LFB1 | MODY3 | TCF1HNF1 homeobox A-HPRD11266540 |12107263 
HNF4AFLJ39654 | HNF4 | HNF4a7 | HNF4a8 | HNF4a9 | MODY | MODY1 | NR2A1 | NR2A21 | TCF | TCF14hepatocyte nuclear factor 4, alphaAffinity Capture-Western
Reconstituted Complex
BioGRID12944908 
IGFBP2IBP2 | IGF-BP53insulin-like growth factor binding protein 2, 36kDaCTNNB1 (beta-catenin) interacts with the IGFBP2 promoter.BIND15735679 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta-HPRD,BioGRID11527961 
IQGAP1HUMORFA01 | KIAA0051 | SAR1 | p195IQ motif containing GTPase activating protein 1-HPRD,BioGRID11734550|12446675 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobinAffinity Capture-WesternBioGRID9535896 |11712088 
KLK3APS | KLK2A1 | PSA | hK3kallikrein-related peptidase 3CTNNB1 (beta-catenin) interacts with the KLK3 (PSA) promoter.BIND15829968 
LEF1DKFZp586H0919 | TCF1ALPHAlymphoid enhancer-binding factor 1-HPRD8757136 |12556497 
Affinity Capture-Western
Two-hybrid
BioGRID8757136 |12748295 
|15684397 
LEF-1 interacts with Beta-catenin. This interaction was modeled on a demonstrated interaction between human LEF-1 and mouse Beta-catenin.BIND15525529 
LGALS9HUAT | LGALS9A | MGC117375 | MGC125973 | MGC125974lectin, galactoside-binding, soluble, 9Affinity Capture-MSBioGRID17353931 
MAGI1AIP3 | BAIAP1 | BAP1 | MAGI-1 | TNRC19 | WWP3membrane associated guanylate kinase, WW and PDZ domain containing 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID10772923 
MAGI2ACVRIP1 | AIP1 | ARIP1 | MAGI-2 | SSCAMmembrane associated guanylate kinase, WW and PDZ domain containing 2-HPRD11826105 
METAUTS9 | HGFR | RCCP2 | c-Metmet proto-oncogene (hepatocyte growth factor receptor)Affinity Capture-WesternBioGRID11254878 
MUC1CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUMmucin 1, cell surface associatedAffinity Capture-Western
Reconstituted Complex
BioGRID9139698 |9819408 
|11152665 |11483589 
|11877440 |12618757 
|12750561 
MUC1 interacts with beta-catenin.BIND11483589 
-HPRD9139698 |11152665 
|11483589 |11877440 
MYO7ADFNA11 | DFNB2 | MYOVIIA | MYU7A | NSRD2 | USH1Bmyosin VIIAAffinity Capture-WesternBioGRID11080149 
NEURL2C20orf163 | MGC125934 | MGC125935 | OZZ | Ozz-E3neuralized homolog 2 (Drosophila)-HPRD14960280 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1NFKB1 (p50) interacts with CTNNB1 (beta-catenin).BIND15829968 
NLKDKFZp761G1211 | FLJ21033nemo-like kinaseAffinity Capture-WesternBioGRID12556497 
NR5A1AD4BP | ELP | FTZ1 | FTZF1 | SF-1 | SF1nuclear receptor subfamily 5, group A, member 1-HPRD,BioGRID12554773 
NR5A2B1F | B1F2 | CPF | FTF | FTZ-F1 | FTZ-F1beta | LRH-1 | hB1F | hB1F-2nuclear receptor subfamily 5, group A, member 2beta-catenin interacts with LRH-1.BIND15327767 
PCSK1BMIQ12 | NEC1 | PC1 | PC3 | SPC3proprotein convertase subtilisin/kexin type 1Affinity Capture-WesternBioGRID11113628 
PECAM1CD31 | PECAM-1platelet/endothelial cell adhesion molecule-HPRD,BioGRID10801826 
PHB2BAP | BCAP37 | Bap37 | MGC117268 | PNAS-141 | REA | p22prohibitin 2Affinity Capture-MSBioGRID17353931 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Reconstituted ComplexBioGRID10477752 
-HPRD11716761 
PIN1DOD | UBL5peptidylprolyl cis/trans isomerase, NIMA-interacting 1-HPRD,BioGRID11533658 
PKD1PBPpolycystic kidney disease 1 (autosomal dominant)Polycystin-1 interacts with beta-catenin.BIND11113628 
-HPRD11274246 
PKP2ARVD9plakophilin 2-HPRD11790773 
PSEN1AD3 | FAD | PS1 | S182presenilin 1Affinity Capture-WesternBioGRID9738936 |9852041 
|10341227 
PS1 interacts with beta-catenin.BIND9632714 
PTNHARP | HBGF8 | HBNF | NEGF1pleiotrophinAffinity Capture-WesternBioGRID10706604 
PTPN1PTP1Bprotein tyrosine phosphatase, non-receptor type 1-HPRD,BioGRID12377785 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11Affinity Capture-WesternBioGRID10681592 
PTPN13DKFZp686J1497 | FAP-1 | PNP1 | PTP-BAS | PTP-BL | PTP1E | PTPL1 | PTPLEprotein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)Reconstituted ComplexBioGRID10951583 
PTPN14MGC126803 | PEZ | PTP36protein tyrosine phosphatase, non-receptor type 14-HPRD,BioGRID12808048 
PTPRBDKFZp686E2262 | DKFZp686H15164 | FLJ44133 | HPTP-BETA | HPTPB | MGC142023 | MGC59935 | PTPB | R-PTP-BETA | VEPTPprotein tyrosine phosphatase, receptor type, B-HPRD10706604 
PTPRFFLJ43335 | FLJ45062 | FLJ45567 | LARprotein tyrosine phosphatase, receptor type, FAffinity Capture-Western
Reconstituted Complex
BioGRID9245795 |11245482 
-HPRD9245795 |12095414 
PTPRJCD148 | DEP1 | HPTPeta | R-PTP-ETA | SCC1protein tyrosine phosphatase, receptor type, J-HPRD,BioGRID12370829 
PTPRKDKFZp686C2268 | DKFZp779N1045 | R-PTP-kappaprotein tyrosine phosphatase, receptor type, K-HPRD,BioGRID8663237 
PTPRUFLJ37530 | FMI | GLEPP1 | PCP-2 | PTP | PTP-J | PTP-PI | PTPPSI | PTPRO | PTPU2 | R-PTP-PSI | hPTP-Jprotein tyrosine phosphatase, receptor type, U-HPRD,BioGRID12501215 
PTPRZ1HPTPZ | HPTPzeta | PTP-ZETA | PTP18 | PTPRZ | PTPZ | RPTPB | RPTPbeta | phosphacanprotein tyrosine phosphatase, receptor-type, Z polypeptide 1-HPRD,BioGRID10706604 
PYGO1DKFZp547G0910pygopus homolog 1 (Drosophila)-HPRD11955446 
RAB8BFLJ38125RAB8B, member RAS oncogene familyAffinity Capture-WesternBioGRID12639940 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating protein-HPRD12531901 
RUVBL1ECP54 | INO80H | NMP238 | PONTIN | Pontin52 | RVB1 | TIH1 | TIP49 | TIP49ARuvB-like 1 (E. coli)Affinity Capture-Western
Reconstituted Complex
BioGRID9843967 
RUVBL2CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49BRuvB-like 2 (E. coli)CTNNB1 (beta-catenin) interacts with RUVBL2 (reptin).BIND15829968 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alphaAffinity Capture-WesternBioGRID12771132 
SGK1SGKserum/glucocorticoid regulated kinase 1CTNNB1 (beta-catenin) interacts with the SGK promoter.BIND15735679 
SKP1EMC19 | MGC34403 | OCP-II | OCP2 | SKP1A | TCEB1L | p19AS-phase kinase-associated protein 1Affinity Capture-WesternBioGRID11389839 
SLC9A3R1EBP50 | NHERF | NHERF1 | NPHLOP2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1-HPRD,BioGRID12830000 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID12000714 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD,BioGRID12000714 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD,BioGRID12000714 
SMAD7CRCS3 | FLJ16482 | MADH7 | MADH8SMAD family member 7Affinity Capture-Western
Co-localization
BioGRID15684397 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4-HPRD,BioGRID11532957 
TAX1BP3TIP-1Tax1 (human T-cell leukemia virus type I) binding protein 3-HPRD12874278 
TBL1XEBI | SMAP55 | TBL1transducin (beta)-like 1X-linked-HPRD,BioGRID11389839 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)-HPRD12107263 
TCF4E2-2 | ITF2 | MGC149723 | MGC149724 | PTHS | SEF2 | SEF2-1 | SEF2-1A | SEF2-1B | bHLHb19transcription factor 4-HPRD11713476|12861022 
Affinity Capture-Western
Co-crystal Structure
Reconstituted Complex
BioGRID11713475 |11713476 
|12657632 |15331612 
TCF7L1TCF-3 | TCF3transcription factor 7-like 1 (T-cell specific, HMG-box)Co-crystal StructureBioGRID11136974 
-HPRD11266540 
TCF7L2TCF-4 | TCF4transcription factor 7-like 2 (T-cell specific, HMG-box)Affinity Capture-WesternBioGRID12861022 
-HPRD11713476 
TCF-4 interacts with Beta-catenin.BIND15525529 
Beta-catenin interacts with TCF4.BIND15294866 
TFAP2AAP-2 | AP-2alpha | AP2TF | BOFS | TFAP2transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)Affinity Capture-WesternBioGRID15331612 
TFF1BCEI | D21S21 | HP1.A | HPS2 | pNR-2 | pS2trefoil factor 1beta-catenin interacts with the pS2 promoter.BIND15304487 
TGFBR1AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1transforming growth factor, beta receptor 1-HPRD12000714 
TGFBR2AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RIItransforming growth factor, beta receptor II (70/80kDa)Affinity Capture-WesternBioGRID12000714 
USP9XDFFRX | FAF | FAMubiquitin specific peptidase 9, X-linked-HPRD,BioGRID10620020 
VCLCMD1W | MVCLvinculinAffinity Capture-WesternBioGRID9405455 
VEZTDKFZp761C241 | VEZATINvezatin, adherens junctions transmembrane protein-HPRD,BioGRID11080149 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 5936All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER 6247All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_THYROID_CANCER 2926All SZGR genes in this pathway
KEGG_BASAL_CELL_CARCINOMA 5544All SZGR genes in this pathway
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 7659All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
BIOCARTA_CELL2CELL_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_GSK3_PATHWAY 2726All SZGR genes in this pathway
BIOCARTA_PITX2_PATHWAY 1515All SZGR genes in this pathway
BIOCARTA_PS1_PATHWAY 1414All SZGR genes in this pathway
BIOCARTA_TFF_PATHWAY 2115All SZGR genes in this pathway
BIOCARTA_WNT_PATHWAY 2624All SZGR genes in this pathway
WNT_SIGNALING 8971All SZGR genes in this pathway
ST_WNT_BETA_CATENIN_PATHWAY 3428All SZGR genes in this pathway
PID_BETA_CATENIN_DEG_PATHWAY 1817All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PID_ARF6_TRAFFICKING_PATHWAY 4934All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
PID_ILK_PATHWAY 4532All SZGR genes in this pathway
PID_NECTIN_PATHWAY 3020All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_WNT_CANONICAL_PATHWAY 2018All SZGR genes in this pathway
PID_FOXO_PATHWAY 4943All SZGR genes in this pathway
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY 3933All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_ECADHERIN_KERATINOCYTE_PATHWAY 2119All SZGR genes in this pathway
PID_BETA_CATENIN_NUC_PATHWAY 8060All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
PID_NCADHERIN_PATHWAY 3332All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 4026All SZGR genes in this pathway
REACTOME_SIGNALING_BY_WNT 6541All SZGR genes in this pathway
REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE 1611All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS 126All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS 2720All SZGR genes in this pathway
REACTOME_CELL_CELL_JUNCTION_ORGANIZATION 5631All SZGR genes in this pathway
REACTOME_CELL_JUNCTION_ORGANIZATION 7843All SZGR genes in this pathway
REACTOME_MYOGENESIS 2820All SZGR genes in this pathway
REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION 2214All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 1912All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE 5437All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
DITTMER_PTHLH_TARGETS_UP 11268All SZGR genes in this pathway
KOINUMA_COLON_CANCER_MSI_UP 1611All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
HWANG_PROSTATE_CANCER_MARKERS 2819All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER 2219All SZGR genes in this pathway
SCHEIDEREIT_IKK_TARGETS 1815All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS 5845All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_DN 2821All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_HELA 164118All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGLL_VS_IGLK_DN 2418All SZGR genes in this pathway
CROMER_METASTASIS_UP 7946All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C5 2111All SZGR genes in this pathway
MA_PITUITARY_FETAL_VS_ADULT_UP 2921All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 3926All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_UP 8959All SZGR genes in this pathway
ZHOU_TNF_SIGNALING_30MIN 5436All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_UP 7757All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_UP 7456All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2 7142All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
HONMA_DOCETAXEL_RESISTANCE 3423All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
ZAIDI_OSTEOBLAST_TRANSCRIPTION_FACTORS 1412All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S2 11574All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_EARLY_UP 6644All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_UP 10467All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
GUILLAUMOND_KLF10_TARGETS_DN 3015All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1393493551Ahsa-miR-139brainUCUACAGUGCACGUGUCU
miR-141/200a6977031Ahsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-2176696751Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-320239245m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-3818298351Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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