Gene Page: CTSK

Summary
GeneID  1513
Symbol  CTSK
Synonyms  CTS02|CTSO|CTSO1|CTSO2|MGC23107|PKND|PYCD
Description  cathepsin K
See related  HGNC:2536|MIM:601105|Ensembl:ENSG00000143387|HPRD:03064|
Locus tag  RP11-363I22.4
Gene type  protein-coding
Map location  1q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CSF1R0.900.89
LAPTM50.880.80
IRF80.870.83
TLR70.860.82
CCR10.850.83
NCKAP1L0.850.78
ITGB20.820.80
LPAR50.820.75
CYBB0.810.84
SIGLEC80.800.72
Top 10 negatively co-expressed genes
AC098691.2-0.35-0.49
FXYD1-0.35-0.47
MT-CO2-0.33-0.52
MT1G-0.33-0.45
AF347015.26-0.33-0.48
AF347015.33-0.30-0.47
CXCL14-0.30-0.39
AF347015.2-0.30-0.47
S100A13-0.30-0.44
AF347015.18-0.30-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI17889653 
GO:0004197cysteine-type endopeptidase activityTAS9143502 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisTAS7818555 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005764lysosomeIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FGFR3ACH | CD333 | CEK2 | HSFGFR3EX | JTK4fibroblast growth factor receptor 3Two-hybridBioGRID16169070 
SERPINB13HSHUR7SEQ | HUR7 | MGC126870 | PI13 | headpinserpin peptidase inhibitor, clade B (ovalbumin), member 13-HPRD12504904 
SERPINB3HsT1196 | SCC | SCCA-1 | SCCA-PD | SCCA1 | T4-Aserpin peptidase inhibitor, clade B (ovalbumin), member 3-HPRD,BioGRID9548757 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_LYSOSOME 12183All SZGR genes in this pathway
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 10288All SZGR genes in this pathway
REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR 1410All SZGR genes in this pathway
REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 9161All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 199124All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_MODERATELY_VS_POORLY_UP 12171All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 151100All SZGR genes in this pathway
NADLER_OBESITY_UP 6134All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_11Q23_DELETION 2318All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_DN 8056All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_0HR 6348All SZGR genes in this pathway
STEARMAN_TUMOR_FIELD_EFFECT_UP 3622All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN 6139All SZGR genes in this pathway
COATES_MACROPHAGE_M1_VS_M2_DN 7844All SZGR genes in this pathway
MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_UP 2414All SZGR genes in this pathway
WILSON_PROTEASES_AT_TUMOR_BONE_INTERFACE_UP 2114All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_BRCA1_DN 4428All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_UP 6242All SZGR genes in this pathway
KANG_AR_TARGETS_DN 1912All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway
ANASTASSIOU_CANCER_MESENCHYMAL_TRANSITION_SIGNATURE 6440All SZGR genes in this pathway
DURAND_STROMA_NS_UP 162103All SZGR genes in this pathway
ZWANG_DOWN_BY_2ND_EGF_PULSE 293119All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_4 1912All SZGR genes in this pathway


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