Gene Page: CYP2D6

Summary
GeneID  1565
Symbol  CYP2D6
Synonyms  CPD6|CYP2D|CYP2D@|CYP2DL1|MGC120389|MGC120390|P450-DB1|P450C2D|P450DB1
Description  cytochrome P450, family 2, subfamily D, polypeptide 6
See related  HGNC:2625|MIM:124030|Ensembl:ENSG00000100197|HPRD:00487|
Locus tag  RP4-669P10.2
Gene type  protein-coding
Map location  22q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PIAS20.400.39
FAM160A10.380.37
GOLT1B0.370.37
PCLO0.370.42
NRBF20.360.39
CASD10.360.37
PLEKHA30.360.37
CCDC920.350.39
MON20.350.39
ZNF280B0.350.43
Top 10 negatively co-expressed genes
IL32-0.34-0.34
HIGD1B-0.34-0.33
MT-CYB-0.34-0.31
MT-CO2-0.34-0.31
CSAG1-0.32-0.32
AF347015.33-0.32-0.29
NOSTRIN-0.31-0.30
AF347015.2-0.31-0.27
AF347015.31-0.31-0.30
AF347015.8-0.30-0.29
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005506iron ion bindingIEA-
GO:0004497monooxygenase activityIEA-
GO:0020037heme bindingIEA-
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenIEA-
GO:0009055electron carrier activityIEA-
GO:0046872metal ion bindingIEA-
GO:0050381unspecific monooxygenase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeIEA-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_DRUG_METABOLISM_CYTOCHROME_P450 7247All SZGR genes in this pathway
REACTOME_BIOLOGICAL_OXIDATIONS 13991All SZGR genes in this pathway
REACTOME_XENOBIOTICS 1611All SZGR genes in this pathway
REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE 5134All SZGR genes in this pathway
REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS 7050All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP 214144All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
ROPERO_HDAC2_TARGETS 11471All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_DN 8759All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BRAIN_DN 8558All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_UP 185112All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway


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