Gene Page: CYP3A4

Summary
GeneID  1576
Symbol  CYP3A4
Synonyms  CP33|CP34|CYP3A|CYP3A3|HLP|MGC126680|NF-25|P450C3|P450PCN1
Description  cytochrome P450, family 3, subfamily A, polypeptide 4
See related  HGNC:2637|MIM:124010|Ensembl:ENSG00000160868|HPRD:00484|
Locus tag  -
Gene type  protein-coding
Map location  7q21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005506iron ion bindingIEA-
GO:0004497monooxygenase activityIEA-
GO:0019825oxygen bindingTAS2492107 |3460094 
GO:0020037heme bindingIEA-
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenIEA-
GO:0009055electron carrier activityIEA-
GO:0033780taurochenodeoxycholate 6alpha-hydroxylase activityIEA-
GO:0046872metal ion bindingIEA-
GO:0050591quinine 3-monooxygenase activityIEA-
GO:0050649testosterone 6-beta-hydroxylase activityIDA11726664 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006805xenobiotic metabolic processTAS11726664 
GO:0006629lipid metabolic processTAS2492107 
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeTAS3460094 
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005624membrane fractionTAS11726664 
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0009986cell surfaceIDA12493773 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_STEROID_HORMONE_BIOSYNTHESIS 5530All SZGR genes in this pathway
KEGG_LINOLEIC_ACID_METABOLISM 2916All SZGR genes in this pathway
KEGG_RETINOL_METABOLISM 6437All SZGR genes in this pathway
KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 7044All SZGR genes in this pathway
KEGG_DRUG_METABOLISM_CYTOCHROME_P450 7247All SZGR genes in this pathway
KEGG_DRUG_METABOLISM_OTHER_ENZYMES 5127All SZGR genes in this pathway
REACTOME_BIOLOGICAL_OXIDATIONS 13991All SZGR genes in this pathway
REACTOME_XENOBIOTICS 1611All SZGR genes in this pathway
REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE 5134All SZGR genes in this pathway
REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS 7050All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
SAENZ_DETOX_PATHWAY_AND_CARCINOGENESIS_DN 1311All SZGR genes in this pathway
DARWICHE_PAPILLOMA_PROGRESSION_RISK 7444All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_7Q21_Q22_AMPLICON 7633All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
AFFAR_YY1_TARGETS_DN 234137All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_DN 8662All SZGR genes in this pathway
MEDINA_SMARCA4_TARGETS 4429All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_UP 180125All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN 8858All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_UP 185112All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP 221150All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
ZHANG_TLX_TARGETS_UP 10878All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_DN 7651All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway


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