Gene Page: DAB2

Summary
GeneID  1601
Symbol  DAB2
Synonyms  DOC-2|DOC2|FLJ26626
Description  disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
See related  HGNC:2662|MIM:601236|Ensembl:ENSG00000153071|HPRD:03139|
Locus tag  -
Gene type  protein-coding
Map location  5p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.056 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ANAPC20.910.90
EGLN20.910.92
EPN10.910.90
HGS0.910.91
AP2A20.900.89
SAPS20.900.90
ARMC50.900.90
LONP10.890.89
LRSAM10.890.89
ZNF6530.890.90
Top 10 negatively co-expressed genes
AF347015.21-0.76-0.74
AF347015.31-0.75-0.69
MT-CO2-0.73-0.68
AF347015.27-0.72-0.69
AF347015.8-0.72-0.68
AF347015.33-0.72-0.66
MT-CYB-0.71-0.66
AF347015.15-0.68-0.65
AF347015.2-0.68-0.64
AC021016.1-0.66-0.67
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008022protein C-terminus bindingIPI15837803 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000904cell morphogenesis involved in differentiationIEA-
GO:0001701in utero embryonic developmentIEA-
GO:0008283cell proliferationTAS9620555 
GO:0007588excretionIEA-
GO:0006907pinocytosisIEA-
GO:0006898receptor-mediated endocytosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0005905coated pitIDA12857860 
GO:0031410cytoplasmic vesicleIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2A2ADTAB | CLAPA2 | HIP9 | HYPJadaptor-related protein complex 2, alpha 2 subunitAffinity Capture-WesternBioGRID11247302 
AP2M1AP50 | CLAPM1 | mu2adaptor-related protein complex 2, mu 1 subunit-HPRD11247302 
APLP1APLPamyloid beta (A4) precursor-like protein 1Reconstituted ComplexBioGRID11247302 
APLP2APPH | APPL2 | CDEBPamyloid beta (A4) precursor-like protein 2Reconstituted ComplexBioGRID11247302 
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor proteinReconstituted ComplexBioGRID11247302 
AXIN1AXIN | MGC52315axin 1Reconstituted ComplexBioGRID12805222 
CDC2CDC28A | CDK1 | DKFZp686L20222 | MGC111195cell division cycle 2, G1 to S and G2 to M-HPRD,BioGRID12881709 
CSKMGC117393c-src tyrosine kinase-HPRD,BioGRID12473651 
DAB2IPAF9Q34 | AIP1 | DIP1/2 | FLJ39072 | KIAA1743DAB2 interacting proteinAffinity Capture-Western
Reconstituted Complex		BioGRID11812785 
DIP2AC21orf106 | DIP2DIP2 disco-interacting protein 2 homolog A (Drosophila)-HPRD11812785 
DVL1DVL | MGC54245dishevelled, dsh homolog 1 (Drosophila)Reconstituted ComplexBioGRID12805222 
DVL2-dishevelled, dsh homolog 2 (Drosophila)Affinity Capture-Western
Reconstituted Complex		BioGRID12805222 
DVL3KIAA0208dishevelled, dsh homolog 3 (Drosophila)-HPRD,BioGRID12805222 
FGRFLJ43153 | MGC75096 | SRC2 | c-fgr | c-src2 | p55c-fgr | p58c-fgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog-HPRD,BioGRID12473651 
INPP5DMGC104855 | MGC142140 | MGC142142 | SHIP | SHIP1 | SIP-145 | hp51CNinositol polyphosphate-5-phosphatase, 145kDaReconstituted ComplexBioGRID11247302 
LDLRFH | FHClow density lipoprotein receptorReconstituted ComplexBioGRID11247302 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)Reconstituted ComplexBioGRID11247302 
LRP2DBS | gp330low density lipoprotein-related protein 2-HPRD,BioGRID10769163 
MIB1DIP-1 | DKFZp686I0769 | DKFZp761M1710 | FLJ90676 | MGC129659 | MGC129660 | MIB | ZZANK2 | ZZZ6mindbomb homolog 1 (Drosophila)-HPRD11812785 
MYO6DFNA22 | DFNB37 | KIAA0389myosin VI-HPRD,BioGRID11906161 |11967127 
PIN1DOD | UBL5peptidylprolyl cis/trans isomerase, NIMA-interacting 1-HPRD,BioGRID12881709 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID11387212 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD,BioGRID11387212 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID12473651 
TGFBR1AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1transforming growth factor, beta receptor 1-HPRD,BioGRID11387212 
TGFBR2AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RIItransforming growth factor, beta receptor II (70/80kDa)-HPRD,BioGRID11387212 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_GAP_JUNCTION_DEGRADATION 108All SZGR genes in this pathway
REACTOME_MEMBRANE_TRAFFICKING 12974All SZGR genes in this pathway
REACTOME_GAP_JUNCTION_TRAFFICKING 2719All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 205140All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
FRASOR_TAMOXIFEN_RESPONSE_UP 5136All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN 384220All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP 175120All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN 14290All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP 185126All SZGR genes in this pathway
PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTIC_PLAQUE_UP 5236All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_2HR_DN 8853All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN 284156All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_UP 164122All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
BIDUS_METASTASIS_DN 16193All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 199124All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN 6743All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
PROVENZANI_METASTASIS_UP 194112All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_DN 153100All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN 14184All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP 185119All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
YANAGIHARA_ESX1_TARGETS 3019All SZGR genes in this pathway
MAINA_VHL_TARGETS_UP 106All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN 5142All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 7151All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
SANA_RESPONSE_TO_IFNG_DN 8556All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP 8864All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN 7748All SZGR genes in this pathway
RORIE_TARGETS_OF_EWSR1_FLI1_FUSION_UP 3022All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
TSENG_IRS1_TARGETS_DN 13588All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_0HR 6348All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_DN 10164All SZGR genes in this pathway
BILD_MYC_ONCOGENIC_SIGNATURE 206117All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION 8865All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
HOQUE_METHYLATED_IN_CANCER 5645All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN 10868All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_D 6844All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
ROSS_LEUKEMIA_WITH_MLL_FUSIONS 7849All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
VALK_AML_CLUSTER_11 3624All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G5_DN 2717All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_UP 7349All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_UP 9362All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_16 7947All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_EARLY_DN 3827All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_DN 8766All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_DN 207139All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_UP 217131All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_GROUP1 13676All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN 9974All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-14973791Ahsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-320105111m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-3301071131Ahsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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