Gene Page: DCC

Summary
GeneID  1630
Symbol  DCC
Synonyms  CRC18|CRCR1
Description  deleted in colorectal carcinoma
See related  HGNC:2701|MIM:120470|Ensembl:ENSG00000187323|HPRD:00391|
Locus tag  -
Gene type  protein-coding
Map location  18q21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EFTUD20.950.96
VCP0.940.94
FBXO210.940.96
DHX80.940.95
GANAB0.940.94
EXT20.940.95
ZNF2070.930.93
PRPF40.930.94
FBXO380.930.93
SND10.930.95
Top 10 negatively co-expressed genes
MT-CO2-0.81-0.88
AF347015.31-0.79-0.86
AF347015.33-0.79-0.86
FXYD1-0.77-0.85
AF347015.8-0.77-0.86
AF347015.21-0.77-0.89
AF347015.27-0.77-0.85
MT-CYB-0.76-0.84
IFI27-0.75-0.81
HIGD1B-0.74-0.82
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004888transmembrane receptor activityTAS8861902 
GO:0005515protein bindingIPI12011067 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007409axonogenesisTASneuron, axon, neurite (GO term level: 12)8861902 
GO:0006917induction of apoptosisTAS9796814 
GO:0006915apoptosisIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0045786negative regulation of cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADORA2BADORA2adenosine A2b receptor-HPRD11048721 
APPL1APPL | DIP13alphaadaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1-HPRD,BioGRID12011067 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12864730 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidase-HPRD,BioGRID11248093 
CASP9APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6caspase 9, apoptosis-related cysteine peptidase-HPRD,BioGRID11248093 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YESDCC interacts with Fyn.BIND15494732 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3-HPRD,BioGRID11986622 
MAZPUR1 | Pur-1 | SAF-1 | SAF-2 | ZF87 | ZNF801 | Zif87MYC-associated zinc finger protein (purine-binding transcription factor)-HPRD,BioGRID11527412 |12509857 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD,BioGRID12149262 
NTN1NTN1Lnetrin 1-HPRD,BioGRID9950216 |12810718 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2Affinity Capture-Western
Two-hybrid		BioGRID15494733 
DCC interacts with FAK.BIND15494732 
FAK interacts with DCC.BIND15494733 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 betaAffinity Capture-WesternBioGRID15494733 
SIAH1FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1seven in absentia homolog 1 (Drosophila)-HPRD,BioGRID9858595 
DCC interacts with Siah-1.BIND9334332 
hSiah1 interacts with DCC cytoplasmic domain.BIND9334332 
SIAH2hSiah2seven in absentia homolog 2 (Drosophila)-HPRD,BioGRID9858595 
DCC interacts with Siah-2.BIND9334332 
hSiah2 interacts with DCC.BIND9334332 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER 6247All SZGR genes in this pathway
PID_NETRIN_PATHWAY 3227All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_REGULATION_OF_APOPTOSIS 5834All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS 105All SZGR genes in this pathway
REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING 118All SZGR genes in this pathway
REACTOME_NETRIN1_SIGNALING 4130All SZGR genes in this pathway
REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING 1311All SZGR genes in this pathway
REACTOME_DSCAM_INTERACTIONS 1110All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_DN 9061All SZGR genes in this pathway
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER 8864All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_VS_CD2_UP 6647All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
HILLION_HMGA1B_TARGETS 9268All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
MIKKELSEN_IPS_HCP_WITH_H3_UNMETHYLATED 8050All SZGR genes in this pathway
MIKKELSEN_ES_HCP_WITH_H3K27ME3 4130All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-4487467531A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-48698104m8hsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-9487493m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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