Gene Page: ACE

Summary
GeneID  1636
Symbol  ACE
Synonyms  ACE1|CD143|DCP|DCP1|MGC26566
Description  angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
See related  HGNC:2707|MIM:106180|Ensembl:ENSG00000159640|HPRD:00108|
Locus tag  -
Gene type  protein-coding
Map location  17q23.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.089 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004180carboxypeptidase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0008241peptidyl-dipeptidase activityIDA1320019 |1668266 |2849100 
|17077303 
GO:0008241peptidyl-dipeptidase activityIEA-
GO:0008241peptidyl-dipeptidase activityISS11303049 
GO:0008237metallopeptidase activityIDA1320019 |1668266 |2849100 
|17077303 
GO:0008237metallopeptidase activityIEA-
GO:0008237metallopeptidase activityISS-
GO:0008144drug bindingIDA1320019 
GO:0008233peptidase activityIEA-
GO:0031404chloride ion bindingIDA12540854 
GO:0031711bradykinin receptor bindingIPI17077303 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0003081regulation of systemic arterial blood pressure by renin-angiotensinIC1668266 
GO:0002005angiotensin catabolic process in bloodIC1668266 
GO:0001822kidney developmentIMP16116425 
GO:0006508proteolysisIEA-
GO:0008217regulation of blood pressureISS11303049 
GO:0042312regulation of vasodilationIC4322742 
GO:0014910regulation of smooth muscle cell migrationISS-
GO:0042447hormone catabolic processIDA7876104 
GO:0042447hormone catabolic processISS11303049 
GO:0019229regulation of vasoconstrictionIC1668266 
GO:0032943mononuclear cell proliferationIC7876104 
GO:0043171peptide catabolic processIDA4322742 
GO:0050482arachidonic acid secretionIDA17077303 
GO:0060218hemopoietic stem cell differentiationIC7876104 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA1668266 |4322742 
GO:0005624membrane fractionIDA1668266 |2849100 
GO:0005768endosomeIDA17077303 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
COMT-catechol-O-methyltransferase-HPRD12729939 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_RENIN_ANGIOTENSIN_SYSTEM 1710All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
BIOCARTA_ACE2_PATHWAY 137All SZGR genes in this pathway
SA_MMP_CYTOKINE_CONNECTION 159All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN 180101All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN 14290All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_DN 153100All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
SANA_TNF_SIGNALING_DN 9057All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
ABE_VEGFA_TARGETS 2015All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
LEIN_CHOROID_PLEXUS_MARKERS 10361All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_UV 6243All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
MATZUK_SPERMATOZOA 11477All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_DN 204114All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-272222281Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.