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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: DCTN1

Summary

GeneID

1639

Symbol

DCTN1

Synonyms

DAP-150|DP-150|HMN7B|P135

Description

dynactin 1 (p150, glued homolog, Drosophila)

Locus tag

Gene type

protein-coding

Map location

2p13

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.3203

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003774

motor activity

IEA

GO:0005515

protein binding

IPI

9722614 |15107855

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007399

nervous system development

NAS

neurite (GO term level: 5)

17360970

GO:0007067

mitosis

NAS

1828535

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000922

spindle pole

IDA

14718566

GO:0005856

cytoskeleton

IEA

GO:0005874

microtubule

IEA

GO:0005737

cytoplasm

TAS

1828535

GO:0030286

dynein complex

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTR1A	ARP1 \| CTRN1 \| FLJ52695 \| FLJ52800 \| FLJ55002	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	-	HPRD	7878030
AKTIP	FT1 \| FTS	AKT interacting protein	Affinity Capture-MS	BioGRID	17353931
APEX1	APE \| APE-1 \| APE1 \| APEN \| APEX \| APX \| HAP1 \| REF-1 \| REF1	APEX nuclease (multifunctional DNA repair enzyme) 1	-	HPRD	9361024
BBS4	-	Bardet-Biedl syndrome 4	Affinity Capture-Western Two-hybrid	BioGRID	15107855
BICD2	KIAA0699 \| bA526D8.1	bicaudal D homolog 2 (Drosophila)	-	HPRD	11483508 \|12447383
BZW1	BZAP45 \| KIAA0005 \| Nbla10236	basic leucine zipper and W2 domains 1	Affinity Capture-MS	BioGRID	17353931
CASP2	CASP-2 \| ICH-1L \| ICH-1L/1S \| ICH1 \| NEDD2	caspase 2, apoptosis-related cysteine peptidase	-	HPRD	11425872
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	-	HPRD	11425872
CASP7	CMH-1 \| ICE-LAP3 \| MCH3	caspase 7, apoptosis-related cysteine peptidase	-	HPRD	11425872
CLIP1	CLIP \| CLIP-170 \| CLIP170 \| CYLN1 \| MGC131604 \| RSN	CAP-GLY domain containing linker protein 1	-	HPRD	12789661
DCTN2	DCTN50 \| DYNAMITIN \| RBP50	dynactin 2 (p50)	p50dynamitin (DCTN2) interacts with an unspecified isoform of p150glued (DCTN1).	BIND	15580264
DST	BP240 \| BPA \| BPAG1 \| CATX-15 \| D6S1101 \| DKFZp564B2416 \| DMH \| DT \| FLJ46791 \| KIAA0465 \| KIAA1470 \| MACF2	dystonin	-	HPRD,BioGRID	14581450
DYNC1H1	DHC1 \| DHC1a \| DKFZp686P2245 \| DNCH1 \| DNCL \| DNECL \| DYHC \| Dnchc1 \| HL-3 \| KIAA0325 \| p22	dynein, cytoplasmic 1, heavy chain 1	Affinity Capture-Western	BioGRID	14600259
DYNC1I2	DNCI2 \| FLJ21089 \| FLJ90842 \| IC2 \| MGC104199 \| MGC111094 \| MGC9324	dynein, cytoplasmic 1, intermediate chain 2	-	HPRD	8522607
EPB41	4.1R \| EL1 \| HE	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	Affinity Capture-Western	BioGRID	10189366
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	8955163
GSTK1	GST13	glutathione S-transferase kappa 1	Affinity Capture-MS	BioGRID	17353931
HAP1	HAP2 \| HIP5 \| HLP \| hHLP1	huntingtin-associated protein 1	-	HPRD,BioGRID	9361024 \|9454836
HTT	HD \| IT15	huntingtin	-	HPRD	9454836
KIF11	EG5 \| HKSP \| KNSL1 \| TRIP5	kinesin family member 11	-	HPRD,BioGRID	9235942
MAP2K3	MAPKK3 \| MEK3 \| MKK3 \| PRKMK3	mitogen-activated protein kinase kinase 3	-	HPRD	15375157
MAP2K6	MAPKK6 \| MEK6 \| MKK6 \| PRKMK6 \| SAPKK3	mitogen-activated protein kinase kinase 6	-	HPRD	15375157
MAPRE1	EB1 \| MGC117374 \| MGC129946	microtubule-associated protein, RP/EB family, member 1	-	HPRD	12388762
PAFAH1B1	LIS1 \| LIS2 \| MDCR \| MDS \| PAFAH	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa	-	HPRD,BioGRID	11889140\|14584027
PLK1	PLK \| STPK13	polo-like kinase 1 (Drosophila)	Affinity Capture-Western	BioGRID	12852857
RAB6A	RAB6 \| RAB6A' \| RAB6B	RAB6A, member RAS oncogene family	Reconstituted Complex Two-hybrid	BioGRID	12401177
RFXANK	ANKRA1 \| BLS \| F14150_1 \| MGC138628 \| RFX-B	regulatory factor X-associated ankyrin-containing protein	Affinity Capture-MS	BioGRID	17353931
SAR1A	SAR1 \| SARA1 \| Sara \| masra2	SAR1 homolog A (S. cerevisiae)	Sar1p (SARA1) interacts with an unspecified isoform of p150glued (DCTN1). This interaction is probably indirect and bridged by Sec23p-Sec24p.	BIND	15580264
SEC23A	CLSD \| MGC26267	Sec23 homolog A (S. cerevisiae)	Sec23A interacts with p150glued (DCTN1).	BIND	15580264
SEC24D	FLJ43974 \| KIAA0755	SEC24 family, member D (S. cerevisiae)	Sec24D interacts with p150glued (DCTN1).	BIND	15580264
SPTBN1	ELF \| SPTB2 \| betaSpII	spectrin, beta, non-erythrocytic 1	Affinity Capture-Western	BioGRID	8991093
SPTBN2	GTRAP41 \| SCA5	spectrin, beta, non-erythrocytic 2	-	HPRD,BioGRID	11461920
TP53BP1	53BP1 \| FLJ41424 \| MGC138366 \| p202	tumor protein p53 binding protein 1	Affinity Capture-Western	BioGRID	15611139
VIM	FLJ36605	vimentin	-	HPRD,BioGRID	14600259

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION	44	30	All SZGR genes in this pathway
KEGG_HUNTINGTONS_DISEASE	185	109	All SZGR genes in this pathway
PID_NCADHERIN_PATHWAY	33	32	All SZGR genes in this pathway
REACTOME_CELL_CYCLE	421	253	All SZGR genes in this pathway
REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION	91	61	All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC	325	185	All SZGR genes in this pathway
REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES	66	43	All SZGR genes in this pathway
REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES	59	38	All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS	133	91	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S	46	34	All SZGR genes in this pathway
REACTOME_UNFOLDED_PROTEIN_RESPONSE	80	51	All SZGR genes in this pathway
REACTOME_MITOTIC_G2_G2_M_PHASES	81	50	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM	539	350	All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP	530	342	All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_DN	185	115	All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_DN	165	107	All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_DN	180	110	All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN	181	107	All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP	414	287	All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_UP	57	35	All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGG_VS_IGA_UP	22	12	All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN	337	230	All SZGR genes in this pathway
JAIN_NFKB_SIGNALING	75	44	All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_UP	69	41	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN	504	323	All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP	244	151	All SZGR genes in this pathway
LEE_AGING_MUSCLE_UP	45	33	All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_DN	54	43	All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP	210	124	All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_UP	69	46	All SZGR genes in this pathway
GRADE_COLON_CANCER_UP	871	505	All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION	456	287	All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP	682	440	All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP	548	370	All SZGR genes in this pathway
MIZUSHIMA_AUTOPHAGOSOME_FORMATION	19	15	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	240	246	m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	240	246	m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.