Gene Page: EEF1A1

Summary
GeneID  1915
Symbol  EEF1A1
Synonyms  CCS-3|CCS3|EEF-1|EEF1A|EF-Tu|EF1A|FLJ25721|GRAF-1EF|HNGC:16303|LENG7|MGC102687|MGC131894|MGC16224|PTI1|eEF1A-1
Description  eukaryotic translation elongation factor 1 alpha 1
See related  HGNC:3189|MIM:130590|Ensembl:ENSG00000156508|HPRD:00559|
Locus tag  RP11-505P4.2
Gene type  protein-coding
Map location  6q14.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.2361 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003746translation elongation factor activityIEA-
GO:0003746translation elongation factor activityNAS3570288 
GO:0003924GTPase activityIEA-
GO:0003924GTPase activityNAS3570288 
GO:0005515protein bindingIPI15231747 |17373842 
GO:0005525GTP bindingIEA-
GO:0005525GTP bindingTAS3512269 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006414translational elongationEXP15189156 
GO:0006414translational elongationIEA-
GO:0006414translational elongationNAS3570288 
GO:0006414translational elongationTAS8812466 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10368288 
GO:0005853eukaryotic translation elongation factor 1 complexTAS2564392 
GO:0005737cytoplasmIEA-
GO:0005737cytoplasmNAS-
GO:0005737cytoplasmTAS3512269 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANKRD24KIAA1981ankyrin repeat domain 24Two-hybridBioGRID16169070 
ARIH2ARI2 | FLJ10938 | FLJ33921 | TRIAD1ariadne homolog 2 (Drosophila)Two-hybridBioGRID16169070 
AXIN1AXIN | MGC52315axin 1Two-hybridBioGRID16169070 
BRMS1DKFZp564A063breast cancer metastasis suppressor 1Two-hybridBioGRID16169070 
BTBD2-BTB (POZ) domain containing 2Two-hybridBioGRID16169070 
C11orf59FLJ20625chromosome 11 open reading frame 59Two-hybridBioGRID16169070 
C11orf79FLJ20487chromosome 11 open reading frame 79Two-hybridBioGRID16169070 
C4BC4A | C4A13 | C4A91 | C4B1 | C4B12 | C4B2 | C4B3 | C4B5 | C4F | CH | CO4 | CPAMD3 | FLJ60561 | MGC164979complement component 4B (Childo blood group)-HPRD,BioGRID10851272 
CCDC130MGC10471coiled-coil domain containing 130Two-hybridBioGRID16169070 
CCL18AMAC-1 | AMAC1 | CKb7 | DC-CK1 | DCCK1 | MIP-4 | PARC | SCYA18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)Two-hybridBioGRID16169070 
CKS2CKSHS2CDC28 protein kinase regulatory subunit 2Two-hybridBioGRID16169070 
COX17MGC104397 | MGC117386COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)Two-hybridBioGRID16169070 
CRADDMGC9163 | RAIDDCASP2 and RIPK1 domain containing adaptor with death domainTwo-hybridBioGRID16169070 
CRCT1C1orf42 | NICE-1cysteine-rich C-terminal 1Two-hybridBioGRID16169070 
DARSDKFZp781B11202 | MGC111579aspartyl-tRNA synthetase-HPRD,BioGRID7806521 
DLEU1BCMS | DLB1 | DLEU2 | LEU1 | LEU2 | MGC22430 | NCRNA00021 | XTP6deleted in lymphocytic leukemia 1 (non-protein coding)Two-hybridBioGRID16169070 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1Two-hybridBioGRID16169070 
EIF3FEIF3S5 | eIF3-p47eukaryotic translation initiation factor 3, subunit FTwo-hybridBioGRID16169070 
EXOSC4FLJ20591 | RRP41 | RRP41A | Rrp41p | SKI6 | Ski6p | hRrp41p | p12Aexosome component 4-HPRD,BioGRID15231747 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)Two-hybridBioGRID16169070 
HBXIPMGC71071 | XIPhepatitis B virus x interacting proteinTwo-hybridBioGRID16169070 
HSPE1CPN10 | GROES | HSP10heat shock 10kDa protein 1 (chaperonin 10)Two-hybridBioGRID16169070 
ITSN1ITSN | MGC134948 | MGC134949 | SH3D1A | SH3P17intersectin 1 (SH3 domain protein)Two-hybridBioGRID16169070 
KIF1BCMT2 | CMT2A | CMT2A1 | FLJ23699 | HMSNII | KIAA0591 | KIAA1448 | KLP | MGC134844kinesin family member 1BTwo-hybridBioGRID16169070 
LAMA4DKFZp686D23145 | LAMA3 | LAMA4*-1laminin, alpha 4Two-hybridBioGRID16169070 
LSM3SMX4 | USS2 | YLR438CLSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)Two-hybridBioGRID16169070 
MAD2L1BPCMT2 | KIAA0110 | MGC11282 | RP1-261G23.6MAD2L1 binding proteinTwo-hybridBioGRID16169070 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7-HPRD14743216 
MLLT3AF9 | FLJ2035 | YEATS3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3Two-hybridBioGRID16169070 
MNAT1MAT1 | RNF66 | TFB3menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)Two-hybridBioGRID16169070 
MRPL42HSPC204 | MRP-L31 | MRPL31 | MRPS32 | PTD007 | RPML31mitochondrial ribosomal protein L42Two-hybridBioGRID16169070 
NEU1FLJ93471 | NANH | NEU | SIAL1sialidase 1 (lysosomal sialidase)Two-hybridBioGRID16169070 
ORMDL3-ORM1-like 3 (S. cerevisiae)Two-hybridBioGRID16169070 
PAEPGD | GdA | GdF | GdS | MGC138509 | MGC142288 | PAEG | PEP | PP14progestagen-associated endometrial proteinTwo-hybridBioGRID16169070 
PAFAH1B3-platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDaTwo-hybridBioGRID16169070 
PAPSS1ATPSK1 | PAPSS | SK13'-phosphoadenosine 5'-phosphosulfate synthase 1Two-hybridBioGRID16169070 
PCDHA4CNR1 | CNRN1 | CRNR1 | MGC138307 | MGC142169 | PCDH-ALPHA4protocadherin alpha 4Two-hybridBioGRID16169070 
PFN2D3S1319E | PFLprofilin 2Two-hybridBioGRID16169070 
PHYHIPDYRK1AP3 | KIAA0273 | PAHX-AP | PAHXAP1phytanoyl-CoA 2-hydroxylase interacting proteinTwo-hybridBioGRID16169070 
PLAURCD87 | UPAR | URKRplasminogen activator, urokinase receptorTwo-hybridBioGRID16169070 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID11886851 
POLE2DPE2polymerase (DNA directed), epsilon 2 (p59 subunit)Two-hybridBioGRID16169070 
POLR2CRPB3 | RPB31 | hRPB33 | hsRPB3polymerase (RNA) II (DNA directed) polypeptide C, 33kDaTwo-hybridBioGRID16169070 
PQBP1MRX55 | MRXS3 | MRXS8 | NPW38 | RENS1 | SHSpolyglutamine binding protein 1Two-hybridBioGRID16169070 
PSG9PSG11 | PSGIIpregnancy specific beta-1-glycoprotein 9Two-hybridBioGRID16169070 
PSMD11MGC3844 | Rpn6 | S9 | p44.5proteasome (prosome, macropain) 26S subunit, non-ATPase, 11Two-hybridBioGRID16169070 
PTPN4PTPMEG | PTPMEG1protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)Two-hybridBioGRID16169070 
PTPRCAPCD45-AP | LPAP | MGC138602 | MGC138603protein tyrosine phosphatase, receptor type, C-associated proteinTwo-hybridBioGRID16169070 
RAB27AGS2 | HsT18676 | MGC117246 | RAB27 | RAMRAB27A, member RAS oncogene familyTwo-hybridBioGRID16169070 
RFC5MGC1155 | RFC36replication factor C (activator 1) 5, 36.5kDaTwo-hybridBioGRID16169070 
RNF10KIAA0262 | MGC126758 | MGC126764 | RIE2ring finger protein 10Two-hybridBioGRID16169070 
RPA2REPA2 | RPA32replication protein A2, 32kDaTwo-hybridBioGRID16169070 
RPLP1FLJ27448 | MGC5215 | P1 | RPP1ribosomal protein, large, P1Two-hybridBioGRID16169070 
RSRC1BM-011 | MGC12197arginine/serine-rich coiled-coil 1Two-hybridBioGRID16169070 
SARS2FLJ20450 | SARS | SARSM | SERS | SYS | SerRSmt | mtSerRSseryl-tRNA synthetase 2, mitochondrial-HPRD15109557 
SERPINB9CAP-3 | CAP3 | PI9serpin peptidase inhibitor, clade B (ovalbumin), member 9Two-hybridBioGRID16169070 
SSR1DKFZp781N23103 | FLJ14232 | FLJ22100 | FLJ23034 | FLJ78242 | FLJ93042 | TRAPAsignal sequence receptor, alphaTwo-hybridBioGRID16169070 
STMN2SCG10 | SCGN10 | SGC10stathmin-like 2Two-hybridBioGRID16169070 
SULT1E1EST | EST-1 | MGC34459 | STEsulfotransferase family 1E, estrogen-preferring, member 1Two-hybridBioGRID16169070 
TAF9AD-004 | AK6 | CGI-137 | CINAP | CIP | MGC1603 | MGC3647 | MGC5067 | MGC:1603 | MGC:3647 | MGC:5067 | TAF2G | TAFII31 | TAFII32 | TAFIID32TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDaTwo-hybridBioGRID16169070 
TGIF1HPE4 | MGC39747 | MGC5066 | TGIFTGFB-induced factor homeobox 1Two-hybridBioGRID16169070 
TMPRSS3DFNB10 | DFNB8 | ECHOS1 | TADG12transmembrane protease, serine 3Two-hybridBioGRID16169070 
TP53BP253BP2 | ASPP2 | BBP | PPP1R13A | p53BP2tumor protein p53 binding protein, 2Two-hybridBioGRID16169070 
TPT1FLJ27337 | HRF | TCTP | p02tumor protein, translationally-controlled 1-HPRD14623968 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD14743216 
TRDMT1DNMT2 | M.HsaIIP | PuMet | RNMT1tRNA aspartic acid methyltransferase 1Two-hybridBioGRID16169070 
TTRHsT2651 | PALB | TBPAtransthyretinTwo-hybridBioGRID16169070 
UBQLN4A1U | C1orf6 | CIP75 | UBINubiquilin 4Two-hybridBioGRID16169070 
VARSG7A | VARS1 | VARS2valyl-tRNA synthetase-HPRD,BioGRID2556394 |3169261 
WARSGAMMA-2 | IFI53 | IFP53tryptophanyl-tRNA synthetaseWRS interacts with EF-1-alpha.BIND11829477 
XPO5FLJ14239 | FLJ32057 | FLJ45606 | KIAA1291exportin 5-HPRD,BioGRID12426393 
XRN2-5'-3' exoribonuclease 2-HPRD,BioGRID15231747 
ZCCHC10FLJ20094zinc finger, CCHC domain containing 10Two-hybridBioGRID16169070 
ZNF24KOX17 | RSG-A | ZNF191 | ZSCAN3 | Zfp191zinc finger protein 24Two-hybridBioGRID16169070 
ZNF259MGC110983 | ZPR1zinc finger protein 259-HPRD,BioGRID9852145 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRANSLATION 22275All SZGR genes in this pathway
REACTOME_PEPTIDE_CHAIN_ELONGATION 15341All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_UP 10867All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_DN 11679All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_2HR_UP 2719All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_UP 5534All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN 214133All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN 6743All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_WITH_7Q_DELETION_DN 3623All SZGR genes in this pathway
JOHANSSON_GLIOMAGENESIS_BY_PDGFB_UP 5844All SZGR genes in this pathway
MATTIOLI_MGUS_VS_PCL 11662All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_EARLY 6648All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_DN 3524All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
ALCALA_APOPTOSIS 8860All SZGR genes in this pathway
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_UP 3532All SZGR genes in this pathway
NADLER_OBESITY_DN 4834All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP 7752All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_DN 8667All SZGR genes in this pathway
MA_MYELOID_DIFFERENTIATION_UP 3929All SZGR genes in this pathway
MUNSHI_MULTIPLE_MYELOMA_UP 8152All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_UP 8366All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_10HR_DN 5637All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_DN 4031All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
MODY_HIPPOCAMPUS_PRENATAL 4233All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN 8858All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_DN 9671All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
KIM_LRRC3B_TARGETS 3024All SZGR genes in this pathway
LEIN_LOCALIZED_TO_PROXIMAL_DENDRITES 3726All SZGR genes in this pathway
EHLERS_ANEUPLOIDY_UP 4129All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DN 10265All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
IRITANI_MAD1_TARGETS_DN 4730All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN 18197All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
WIERENGA_PML_INTERACTOME 4223All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
BILANGES_SERUM_AND_RAPAMYCIN_SENSITIVE_GENES 6835All SZGR genes in this pathway
BILANGES_SERUM_RESPONSE_TRANSLATION 3720All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-33116122m8hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-382235241m8hsa-miR-382brainGAAGUUGUUCGUGGUGGAUUCG
miR-542-3p2532591Ahsa-miR-542-3pUGUGACAGAUUGAUAACUGAAA
miR-543148154m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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