Gene Page: EIF4E

Summary
GeneID  1977
Symbol  EIF4E
Synonyms  CBP|EIF4E1|EIF4EL1|EIF4F|MGC111573
Description  eukaryotic translation initiation factor 4E
See related  HGNC:3287|MIM:133440|Ensembl:ENSG00000151247|HPRD:00591|
Locus tag  -
Gene type  protein-coding
Map location  4q21-q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0067 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AP003117.10.790.84
CTBS0.770.73
CRYL10.770.76
TMBIM10.770.81
SERPINB60.760.78
GRAMD30.750.81
LACTB20.750.78
CD90.740.80
PIR0.740.75
CSRP10.740.79
Top 10 negatively co-expressed genes
KIAA1543-0.60-0.64
NOVA2-0.60-0.64
CHD3-0.60-0.63
DPF1-0.59-0.64
MARCH4-0.59-0.63
ZNF821-0.59-0.63
KIAA1949-0.58-0.60
MPP3-0.58-0.61
GPSM1-0.58-0.60
KIF21B-0.58-0.62
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000339RNA cap bindingTAS3469651 
GO:0003743translation initiation factor activityISS-
GO:0005515protein bindingIPI9878069 |10856257 |15153109 
|15247416 |16739988 
|17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006413translational initiationIEA-
GO:0006417regulation of translationIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP7935836 |8449919 |12588972 
|15809305 
GO:0005737cytoplasmIEA-
GO:0016281eukaryotic translation initiation factor 4F complexTAS3469651 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EIF3BEIF3-ETA | EIF3-P110 | EIF3-P116 | EIF3S9 | MGC104664 | MGC131875 | PRT1eukaryotic translation initiation factor 3, subunit BAffinity Capture-WesternBioGRID16541103 
EIF4A1DDX2A | EIF-4A | EIF4Aeukaryotic translation initiation factor 4A, isoform 1Affinity Capture-MS
Affinity Capture-Western		BioGRID16648488 |17353931 
EIF4A2BM-010 | DDX2B | EIF4A | EIF4Feukaryotic translation initiation factor 4A, isoform 2Affinity Capture-MSBioGRID17353931 
EIF4ECBP | EIF4E1 | EIF4EL1 | EIF4F | MGC111573eukaryotic translation initiation factor 4EAffinity Capture-WesternBioGRID16648488 
EIF4EBP14E-BP1 | 4EBP1 | BP-1 | MGC4316 | PHAS-Ieukaryotic translation initiation factor 4E binding protein 1EIF4E interacts with EIF4EBP1 (4EBP1).BIND10022874 
-HPRD,BioGRID11605658 
EIF4EBP24EBP2 | PHASIIeukaryotic translation initiation factor 4E binding protein 2-HPRD,BioGRID7651417 |7935836 
EIF4EBP34E-BP3eukaryotic translation initiation factor 4E binding protein 3-HPRD,BioGRID12482586 
EIF4ENIF14E-T | Clast4 | FLJ21601 | FLJ26551eukaryotic translation initiation factor 4E nuclear import factor 1-HPRD,BioGRID10856257 
EIF4G1DKFZp686A1451 | EIF4F | EIF4G | p220eukaryotic translation initiation factor 4 gamma, 1-HPRD,BioGRID10600798 
-HPRD9372926 |10600798|10600798 
EIF4E interacts with eIF4G1. This interaction was modeled on a demonstrated interaction between mouse eIF4E and human eIF4G1.BIND9878069 
eIF4GI interacts with eIF4E. This interaction was modeled on a demonstrated interaction between human eIF4GI and monkey eIF4E.BIND15361857 
eIF-4E interacts with an unspecified isoform of eIF-4G.BIND15897904 
EIF4G2AAG1 | DAP5 | FLJ41344 | NAT1 | p97eukaryotic translation initiation factor 4 gamma, 2Affinity Capture-Western
Far Western		BioGRID9418880 
-HPRD10394359 
EIF4G3eIF4GIIeukaryotic translation initiation factor 4 gamma, 3-HPRD9418880 
MAPKAPK5PRAKmitogen-activated protein kinase-activated protein kinase 5-HPRD9628874 
MKNK1MNK1MAP kinase interacting serine/threonine kinase 1Affinity Capture-WesternBioGRID9878069 
EIF4E interacts with Mnk1. This interaction was modeled on a demonstrated interaction between mouse eIF4E and human Mnk1.BIND9878069 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD,BioGRID11500381 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MTOR_SIGNALING_PATHWAY 5240All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
BIOCARTA_EIF_PATHWAY 169All SZGR genes in this pathway
BIOCARTA_MTOR_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_EIF4_PATHWAY 2419All SZGR genes in this pathway
BIOCARTA_IGF1MTOR_PATHWAY 2014All SZGR genes in this pathway
BIOCARTA_SARS_PATHWAY 105All SZGR genes in this pathway
ST_ERK1_ERK2_MAPK_PATHWAY 3225All SZGR genes in this pathway
ST_P38_MAPK_PATHWAY 3728All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_MYC_ACTIV_PATHWAY 7962All SZGR genes in this pathway
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 3829All SZGR genes in this pathway
REACTOME_TRANSLATION 22275All SZGR genes in this pathway
REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 6645All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 14077All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 8430All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM 5434All SZGR genes in this pathway
REACTOME_MRNA_PROCESSING 16186All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 17651All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT 3321All SZGR genes in this pathway
REACTOME_DEADENYLATION_OF_MRNA 2214All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 4829All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_PKB_MEDIATED_EVENTS 2923All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_MTORC1_MEDIATED_SIGNALLING 118All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_PI3K_CASCADE 7151All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN 13686All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
CHOW_RASSF1_TARGETS_UP 2717All SZGR genes in this pathway
CAIRO_PML_TARGETS_BOUND_BY_MYC_UP 2317All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM 15993All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_SMALL_VS_HUGE_UP 3829All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_DN 7652All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_UP 197110All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP 205126All SZGR genes in this pathway
BROCKE_APOPTOSIS_REVERSED_BY_IL6 14498All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_DN 12986All SZGR genes in this pathway
XU_RESPONSE_TO_TRETINOIN_AND_NSC682994_DN 1512All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
ZHU_CMV_ALL_UP 12089All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D2 4130All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C4 1812All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN 312203All SZGR genes in this pathway
ZHU_CMV_24_HR_UP 9365All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_UP 5641All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_BPA_E2 11865All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
DANG_MYC_TARGETS_UP 143100All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1 14895All SZGR genes in this pathway
THILLAINADESAN_ZNF217_TARGETS_UP 4422All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
IKEDA_MIR1_TARGETS_DN 77All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206790796m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-15/16/195/424/4974965021Ahsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-1505258m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-186652658m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-203.17097151Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-2056016071Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-330869875m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-376c729735m8hsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-377737743m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-493-5p9249301Ahsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-5034965021Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-96369m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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