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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: EPHB1

Summary

GeneID

2047

Symbol

EPHB1

Synonyms

ELK|EPHT2|FLJ37986|Hek6|NET

Description

EPH receptor B1

Locus tag

Gene type

protein-coding

Map location

3q21-q23

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0004872

receptor activity

IEA

GO:0005003

ephrin receptor activity

IEA

GO:0005515

protein binding

IPI

8798570

GO:0005524

ATP binding

IEA

GO:0016740

transferase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007399

nervous system development

TAS

neurite (GO term level: 5)

8666391

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

IEA

GO:0006468

protein amino acid phosphorylation

IEA

GO:0007165

signal transduction

TAS

8666391

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005886

plasma membrane

TAS

8666391

GO:0005887

integral to plasma membrane

TAS

8666391

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACP1	HAAP \| MGC111030 \| MGC3499	acid phosphatase 1, soluble	-	HPRD,BioGRID	9499402
EFNA5	AF1 \| EFL5 \| EPLG7 \| GLC1M \| LERK7 \| RAGS	ephrin-A5	-	HPRD,BioGRID	9245480
EFNB1	CFND \| CFNS \| EFL3 \| EPLG2 \| Elk-L \| LERK2 \| MGC8782	ephrin-B1	The membrane bound ligand ELK-L interacts with the receptor ELK. This interaction was modeled on a demonstrated interaction between ELK-L from human and ELK from rat.	BIND	7973638 \|8755474
EFNB1	CFND \| CFNS \| EFL3 \| EPLG2 \| Elk-L \| LERK2 \| MGC8782	ephrin-B1	-	HPRD,BioGRID	10669731 \|12223469
EFNB2	EPLG5 \| HTKL \| Htk-L \| LERK5 \| MGC126226 \| MGC126227 \| MGC126228	ephrin-B2	-	HPRD	8559144 \|10066262
EFNB2		ephrin-B2	The membrane bound ligand HTK-L interacts with the receptor ELK. This interaction was modeled on a demonstrated interaction between HTK-L from human and ELK from rat.	BIND	8755474
EPHB6	HEP \| MGC129910 \| MGC129911	EPH receptor B6	-	HPRD	11713248
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	Two-hybrid	BioGRID	8798570
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	8798570
NCK1	MGC12668 \| NCK \| NCKalpha	NCK adaptor protein 1	-	HPRD,BioGRID	9430661
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	Elk phosphorylates PDGFR. This interaction was modelled on a demonstrated interaction between Elk from an unknown species and human PDGFR.	BIND	7689724

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_AXON_GUIDANCE	129	103	All SZGR genes in this pathway
BIOCARTA_EPHA4_PATHWAY	10	8	All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY	40	38	All SZGR genes in this pathway
PID_EPHRINB_REV_PATHWAY	30	25	All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP	184	125	All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP	238	144	All SZGR genes in this pathway
YEMELYANOV_GR_TARGETS_DN	10	8	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN	428	306	All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS	1038	678	All SZGR genes in this pathway
BENPORATH_EED_TARGETS	1062	725	All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3	1118	744	All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS	652	441	All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_HP_UP	49	26	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN	830	547	All SZGR genes in this pathway
KIM_GASTRIC_CANCER_CHEMOSENSITIVITY	103	64	All SZGR genes in this pathway
LEIN_MIDBRAIN_MARKERS	82	55	All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP	430	288	All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_DN	58	39	All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION	175	125	All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP	165	118	All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3	435	318	All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL	177	132	All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP	489	314	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-129-5p	661	667	m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	661	667	m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-140	676	683	1A,m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-182	541	548	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-186	399	405	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-28	509	515	m8	hsa-miR-28^brain	AAGGAGCUCACAGUCUAUUGAG
miR-450	661	667	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-452	781	788	1A,m8	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC
miR-539	1266	1272	m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-96	542	548	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.