Gene Page: EPHX2

Summary
GeneID  2053
Symbol  EPHX2
Synonyms  CEH|SEH
Description  epoxide hydrolase 2, cytoplasmic
See related  HGNC:3402|MIM:132811|Ensembl:ENSG00000120915|HPRD:00582|
Locus tag  -
Gene type  protein-coding
Map location  8p21-p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AAMP0.900.88
GRK60.890.88
COBRA10.890.88
ATG4B0.890.87
STK250.890.86
BBS10.890.88
THAP40.890.85
RIC8A0.890.88
B4GALT70.880.87
TMUB20.880.86
Top 10 negatively co-expressed genes
MT-CO2-0.75-0.70
AF347015.21-0.75-0.74
AF347015.8-0.74-0.71
AF347015.31-0.74-0.70
AF347015.27-0.73-0.72
MT-CYB-0.72-0.69
AF347015.33-0.72-0.68
AF347015.2-0.71-0.68
AF347015.15-0.70-0.67
AF347015.26-0.69-0.66
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000287magnesium ion bindingIEA-
GO:0004301epoxide hydrolase activityIDA10862610 
GO:0016787hydrolase activityIEA-
GO:0042803protein homodimerization activityNAS10862610 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008217regulation of blood pressureNAS10862610 
GO:0008152metabolic processIEA-
GO:0009636response to toxinNAS10862610 
GO:0017144drug metabolic processNAS10862610 
GO:0006805xenobiotic metabolic processNAS10862610 
GO:0006800oxygen and reactive oxygen species metabolic processNAS10862610 
GO:0006954inflammatory responseNAS10862610 
GO:0006874cellular calcium ion homeostasisNAS10862610 
GO:0019439aromatic compound catabolic processIEA-
GO:0045909positive regulation of vasodilationNAS10862610 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolNAS10862610 
GO:0005625soluble fractionNAS10862610 
GO:0005737cytoplasmIEA-
GO:0005777peroxisomeIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ARACHIDONIC_ACID_METABOLISM 5836All SZGR genes in this pathway
KEGG_PEROXISOME 7847All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN 12686All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
LANDIS_BREAST_CANCER_PROGRESSION_DN 7043All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_DN 14993All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_UP 176111All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_TGFA_DN 6544All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_DN 6438All SZGR genes in this pathway
LEE_LIVER_CANCER_DENA_DN 7445All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C7 6844All SZGR genes in this pathway
YANG_MUC2_TARGETS_DUODENUM_3MO_DN 2314All SZGR genes in this pathway
YANG_MUC2_TARGETS_DUODENUM_6MO_DN 2112All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G123_DN 5130All SZGR genes in this pathway
KAPOSI_LIVER_CANCER_MET_DN 65All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_DN 8054All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN 7447All SZGR genes in this pathway
NIELSEN_LEIOMYOSARCOMA_DN 1811All SZGR genes in this pathway
BAE_BRCA1_TARGETS_UP 7547All SZGR genes in this pathway
NOUSHMEHR_GBM_SILENCED_BY_METHYLATION 5032All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
WANG_CLASSIC_ADIPOGENIC_TARGETS_OF_PPARG 2615All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_DN 213127All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_36HR 15288All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
RAO_BOUND_BY_SALL4 227149All SZGR genes in this pathway


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