Gene Page: EZH2

Summary
GeneID  2146
Symbol  EZH2
Synonyms  ENX-1|EZH1|KMT6|MGC9169
Description  enhancer of zeste homolog 2 (Drosophila)
See related  HGNC:3527|MIM:601573|Ensembl:ENSG00000106462|HPRD:03342|
Locus tag  -
Gene type  protein-coding
Map location  7q35-q36
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0238 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NPB0.790.74
PRR70.780.80
CNIH20.740.75
CPNE20.710.67
B9D20.700.71
RP11-544M22.10.700.75
LY6H0.700.76
EPCAM0.700.65
AC100793.20.690.63
DUSP230.680.66
Top 10 negatively co-expressed genes
AF347015.2-0.42-0.46
MT-CO2-0.42-0.44
AF347015.8-0.41-0.45
AF347015.15-0.40-0.44
AF347015.26-0.40-0.46
AF347015.27-0.39-0.43
AF347015.33-0.39-0.42
MT-CYB-0.39-0.43
MT-ATP8-0.38-0.47
AF347015.31-0.38-0.41
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingTAS8954776 
GO:0005515protein bindingIPI16357870 |17560333 
GO:0016740transferase activityIEA-
GO:0008168methyltransferase activityIEA-
GO:0018024histone-lysine N-methyltransferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentTAS8921387 
GO:0006350transcriptionIEA-
GO:0016568chromatin modificationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0035098ESC/E(Z) complexIDA15385962 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATP1A1MGC3285 | MGC51750ATPase, Na+/K+ transporting, alpha 1 polypeptideTwo-hybridBioGRID16169070 
ATRXATR2 | MGC2094 | MRXHF1 | RAD54 | RAD54L | SFM1 | SHS | XH2 | XNP | ZNF-HXalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)-HPRD,BioGRID9499421 
CCDC85BDIPAcoiled-coil domain containing 85BTwo-hybridBioGRID16189514 
E2F6E2F-6 | MGC111545E2F transcription factor 6-HPRD15536069 
EEDHEED | WAIT1embryonic ectoderm developmentAffinity Capture-Western
Co-fractionation
Reconstituted Complex
Two-hybrid		BioGRID9584197 |9742080 
|10581039 
-HPRD9584197|10581039 
EZH2 interacts with EED.BIND15225548 
GTF3C1DKFZp686A111 | TFIIIC | TFIIIC220 | TFIIICalphageneral transcription factor IIIC, polypeptide 1, alpha 220kDaTwo-hybridBioGRID16169070 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD,BioGRID10581039 
HDAC2RPD3 | YAF1histone deacetylase 2Affinity Capture-WesternBioGRID10581039 
KLHDC2HCLP-1 | LCPkelch domain containing 2Two-hybridBioGRID16169070 
PHF1MTF2L2 | PCL1 | PHF2PHD finger protein 1-HPRD,BioGRID11571280 
PIN4EPVH | MGC138486 | PAR14 | PAR17protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)Two-hybridBioGRID16169070 
POLA2FLJ21662 | FLJ37250polymerase (DNA directed), alpha 2 (70kD subunit)Two-hybridBioGRID16169070 
PSMB6DELTA | LMPY | MGC5169 | Yproteasome (prosome, macropain) subunit, beta type, 6Two-hybridBioGRID16169070 
RP4-691N24.1FLJ11792 | KIAA0980 | NLP | dJ691N24.1ninein-likeTwo-hybridBioGRID16169070 
RPN2RIBIIR | RPN-II | RPNII | SWP1ribophorin IITwo-hybridBioGRID16169070 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID8649418 |10780782 
WDR61REC14 | SKI8WD repeat domain 61Two-hybridBioGRID16169070 
WSB2MGC10210 | SBA2WD repeat and SOCS box-containing 2Two-hybridBioGRID16169070 
YY1DELTA | INO80S | NF-E1 | UCRBP | YIN-YANG-1YY1 transcription factorEED interacts with EZH2.BIND14610174 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PYEON_HPV_POSITIVE_TUMORS_UP 9847All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP 15184All SZGR genes in this pathway
LIU_CMYB_TARGETS_UP 165106All SZGR genes in this pathway
LIU_VMYB_TARGETS_UP 12778All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP 8443All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_UP 8745All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP 181101All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
HAHTOLA_SEZARY_SYNDROM_UP 9858All SZGR genes in this pathway
PROVENZANI_METASTASIS_UP 194112All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_UP 11578All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
MISSIAGLIA_REGULATED_BY_METHYLATION_DN 12267All SZGR genes in this pathway
TANG_SENESCENCE_TP53_TARGETS_DN 5733All SZGR genes in this pathway
KONG_E2F3_TARGETS 9758All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION 7751All SZGR genes in this pathway
ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 14073All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_UP 3024All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_DN 165104All SZGR genes in this pathway
BENPORATH_PROLIFERATION 14780All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED 10068All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_DN 9055All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_DN 7543All SZGR genes in this pathway
PARK_HSC_VS_MULTIPOTENT_PROGENITORS_DN 1812All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_METASTASIS_DN 12165All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
LE_EGR2_TARGETS_UP 10875All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_SUBGROUPS 3020All SZGR genes in this pathway
MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_DN 7345All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN 163115All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_PR_UP 4520All SZGR genes in this pathway
STAEGE_EWING_FAMILY_TUMOR 3322All SZGR genes in this pathway
VERNELL_RETINOBLASTOMA_PATHWAY_UP 7047All SZGR genes in this pathway
ZHAN_V2_LATE_DIFFERENTIATION_GENES 4534All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN 172107All SZGR genes in this pathway
SU_TESTIS 7653All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
RHODES_UNDIFFERENTIATED_CANCER 6944All SZGR genes in this pathway
BURTON_ADIPOGENESIS_3 10164All SZGR genes in this pathway
SONG_TARGETS_OF_IE86_CMV_PROTEIN 6042All SZGR genes in this pathway
LIANG_SILENCED_BY_METHYLATION_DN 117All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_UP 7148All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
GAZIN_EPIGENETIC_SILENCING_BY_KRAS 2616All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_MARKERS 1916All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP 425253All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
LU_TUMOR_ANGIOGENESIS_UP 2522All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
CHANG_CYCLING_GENES 14883All SZGR genes in this pathway
MUELLER_COMMON_TARGETS_OF_AML_FUSIONS_DN 3121All SZGR genes in this pathway
HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_DN 5033All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
ZHANG_TLX_TARGETS_DN 8950All SZGR genes in this pathway
CROONQUIST_NRAS_VS_STROMAL_STIMULATION_DN 9965All SZGR genes in this pathway
ISHIDA_E2F_TARGETS 5327All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP 178108All SZGR genes in this pathway
PUJANA_BREAST_CANCER_WITH_BRCA1_MUTATED_UP 5627All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP 19395All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
KAMMINGA_SENESCENCE 4126All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_S 16286All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_6HR 8549All SZGR genes in this pathway
ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_24HR 12873All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98713m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-1015965m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-124.13642m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/50636421Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-138171177m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-1441151211Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-2178692m8hsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
hsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-25/32/92/363/3672062121Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-262502571A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-37846521Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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