Gene Page: RIMS1

Summary
GeneID  22999
Symbol  RIMS1
Synonyms  CORD7|KIAA0340|MGC167823|MGC176677|RAB3IP2|RIM|RIM1
Description  regulating synaptic membrane exocytosis 1
See related  HGNC:17282|MIM:606629|HPRD:09435|
Locus tag  RP5-1046G13.1
Gene type  protein-coding
Map location  6q12-q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BCLAF10.970.98
ZMYM40.960.97
ZNF518B0.960.98
WAPAL0.960.97
AP001011.30.960.97
ZNF5070.960.96
RBM160.960.97
ZMYM20.960.97
WHSC1L10.960.97
KIAA05860.960.96
Top 10 negatively co-expressed genes
FXYD1-0.76-0.87
AF347015.31-0.76-0.87
MT-CO2-0.76-0.88
IFI27-0.74-0.87
AF347015.27-0.73-0.84
AF347015.33-0.73-0.83
HIGD1B-0.72-0.86
AF347015.8-0.72-0.86
MT-CYB-0.72-0.83
HSD17B14-0.72-0.79
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11438518 
GO:0005515protein bindingISS-
GO:0008270zinc ion bindingIEA-
GO:0017137Rab GTPase bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045055regulated secretory pathwayNASNeurotransmitter (GO term level: 7)11438518 
GO:0048169regulation of long-term neuronal synaptic plasticityIEAneuron, Synap (GO term level: 10)-
GO:0016079synaptic vesicle exocytosisTASneuron, Synap, Neurotransmitter (GO term level: 9)11438518 
GO:0006836neurotransmitter transportIEAneuron, Neurotransmitter (GO term level: 5)-
GO:0006461protein complex assemblyIDA11438518 
GO:0007601visual perceptionIEA-
GO:0006944membrane fusionNAS11438518 
GO:0006886intracellular protein transportIEA-
GO:0050896response to stimulusIEA-
GO:0017156calcium ion-dependent exocytosisTAS11438518 
GO:0046903secretionNAS11438518 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042734presynaptic membraneISSneuron, axon, Synap (GO term level: 5)-
GO:0042734presynaptic membraneNASneuron, axon, Synap (GO term level: 5)11438518 
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BSNZNF231bassoon (presynaptic cytomatrix protein)Affinity Capture-WesternBioGRID14734538 
CAMK2ACAMKA | KIAA0968calcium/calmodulin-dependent protein kinase II alphaBiochemical ActivityBioGRID12871946 
ERC1Cast2 | ELKS | KIAA1081 | MGC12974 | RAB6IP2ELKS/RAB6-interacting/CAST family member 1-HPRD12391317 
ERC2CAST | CAST1 | ELKSL | KIAA0378 | MGC133063 | MGC133064 | SPBC110 | Spc110ELKS/RAB6-interacting/CAST family member 2-HPRD,BioGRID12163476 
LRRK1FLJ23119 | FLJ27465 | KIAA1790 | RIPK6 | Roco1leucine-rich repeat kinase 1Affinity Capture-MSBioGRID17353931 
RAB10-RAB10, member RAS oncogene familyAffinity Capture-WesternBioGRID12578829 
RAB26V46133RAB26, member RAS oncogene familyAffinity Capture-WesternBioGRID12578829 
RAB37FLJ30284 | FLJ32507RAB37, member RAS oncogene familyAffinity Capture-WesternBioGRID12578829 
RAB3A-RAB3A, member RAS oncogene familyAffinity Capture-Western
Reconstituted Complex		BioGRID11343654 |12578829 
RAB3B-RAB3B, member RAS oncogene familyAffinity Capture-WesternBioGRID12578829 
RAB3C-RAB3C, member RAS oncogene familyAffinity Capture-WesternBioGRID12578829 
RAB3DD2-2 | GOV | RAB16 | RAD3DRAB3D, member RAS oncogene familyAffinity Capture-WesternBioGRID12578829 
UNC13BMGC133279 | MGC133280 | MUNC13 | UNC13 | Unc13h2 | hmunc13unc-13 homolog B (C. elegans)-HPRD,BioGRID11343654 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptideAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12871946 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE 1513All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 3430All SZGR genes in this pathway
REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE 1111All SZGR genes in this pathway
REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE 109All SZGR genes in this pathway
REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE 1010All SZGR genes in this pathway
REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION 1716All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_UP 266142All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-12817681774m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-130/301112511311Ahsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-133170217081Ahsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-13515811587m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-141/200a3823891A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-142-5p16641670m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-1453223291A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-19119411947m8hsa-miR-191brainCAACGGAAUCCCAAAAGCAGCU
miR-199109911051Ahsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-203.111601166m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-208201120171Ahsa-miR-208AUAAGACGAGCAAAAAGCUUGU
miR-218118111881A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-219941011A,m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-30-5p115611621Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-325193319401A,m8hsa-miR-325CCUAGUAGGUGUCCAGUAAGUGU
miR-338856862m8hsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-34b18031809m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-3753173231Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
miR-495159315991Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-496205620621Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-499201120171Ahsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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