Gene Page: WWC1

Summary
GeneID  23286
Symbol  WWC1
Synonyms  FLJ10865|FLJ23369|KIAA0869|KIBRA
Description  WW and C2 domain containing 1
See related  HGNC:29435|MIM:610533|Ensembl:ENSG00000113645|HPRD:10033|
Locus tag  -
Gene type  protein-coding
Map location  5q35.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.0276 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0762 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RFK0.790.84
TCEAL10.770.80
RNF110.760.83
GABRA50.760.81
UPP20.750.75
MOCS20.750.73
ARF30.740.82
ARL60.730.79
SNX30.730.70
AMN10.730.78
Top 10 negatively co-expressed genes
SORBS3-0.44-0.46
AF347015.18-0.41-0.37
NSBP1-0.40-0.47
AC010618.2-0.40-0.39
AC069281.3-0.39-0.44
ARHGEF1-0.39-0.38
MICALL2-0.39-0.40
SLC27A1-0.38-0.36
AC098691.2-0.38-0.41
PLXNB1-0.38-0.40
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C1orf103FLJ11269 | RIF1 | RP11-96K19.1chromosome 1 open reading frame 103Two-hybridBioGRID16169070 
CDC73C1orf28 | FLJ23316 | HPT-JT | HRPT2cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)Two-hybridBioGRID16169070 
DDNKIAA0749dendrin-HPRD12559952 
PRKCZPKC-ZETA | PKC2protein kinase C, zeta-HPRD,BioGRID15081397 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_SIGNALING_BY_HIPPO 2215All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP 238144All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_UP 14984All SZGR genes in this pathway
LANDIS_BREAST_CANCER_PROGRESSION_UP 4427All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_UP 15093All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP 214144All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP 271175All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_3 4831All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_2 4231All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
WANG_HCP_PROSTATE_CANCER 11169All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_UP 3728All SZGR genes in this pathway
GERY_CEBP_TARGETS 12690All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_DN 215132All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G6 153112All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_UP 388234All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
BRUECKNER_TARGETS_OF_MIRLET7A3_UP 11169All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_UP 8550All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
KYNG_NORMAL_AGING_DN 3013All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_DN 2914All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5 3022All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1 14895All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP 211131All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
DURAND_STROMA_NS_UP 162103All SZGR genes in this pathway
ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF 222159All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1382212271Ahsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-1552242311A,m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-25/32/92/363/3673803861Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-3812422481Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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