Gene Page: GCG

Summary
GeneID  2641
Symbol  GCG
Synonyms  GLP1|GLP2|GRPP
Description  glucagon
See related  HGNC:4191|MIM:138030|HPRD:00676|
Locus tag  -
Gene type  protein-coding
Map location  2q36-q37
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02395 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LASS10.760.81
PPP1R3G0.680.70
AC018755.90.660.71
SLC9A3R20.650.66
GRRP10.650.63
KANK30.650.69
UCN0.640.62
GP1BB0.640.63
TRIM470.640.66
NEU40.630.59
Top 10 negatively co-expressed genes
ZC3H8-0.51-0.51
NUPL1-0.49-0.50
ZRANB2-0.48-0.50
ZNF780B-0.48-0.48
ELP2-0.48-0.49
CDC7-0.48-0.48
CCNT2-0.47-0.48
TTC21B-0.47-0.48
RAD50-0.47-0.48
ZNF248-0.47-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayTAS9990065 
GO:0007165signal transductionTAS7929237 
GO:0008283cell proliferationTAS10861272 
GO:0009755hormone-mediated signalingEXP12626323 
GO:0007631feeding behaviorTAS8538742 
GO:0050796regulation of insulin secretionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005625soluble fractionTAS10861272 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CPE-carboxypeptidase E-HPRD11375130 
GCGRGGR | MGC138246glucagon receptor-HPRD8382034 
GLP1RMGC138331glucagon-like peptide 1 receptor-HPRD,BioGRID11116211 
GLP2R-glucagon-like peptide 2 receptor-HPRD11738243 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_HNF3A_PATHWAY 4429All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION 3423All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 4328All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS 8858All SZGR genes in this pathway
REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS 3322All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN 1611All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION 2214All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 1912All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
BARRIER_CANCER_RELAPSE_NORMAL_SAMPLE_UP 3221All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
HOEGERKORP_CD44_TARGETS_TEMPORAL_DN 2516All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_DN 8049All SZGR genes in this pathway
SU_PANCREAS 5430All SZGR genes in this pathway
CHEN_ETV5_TARGETS_SERTOLI 2010All SZGR genes in this pathway
TSENG_IRS1_TARGETS_UP 11371All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
ROLEF_GLIS3_TARGETS 3729All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-330106112m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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