Gene Page: GNAI1

Summary
GeneID  2770
Symbol  GNAI1
Synonyms  Gi
Description  guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
See related  HGNC:4384|MIM:139310|Ensembl:ENSG00000127955|HPRD:00756|
Locus tag  -
Gene type  protein-coding
Map location  7q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.2615 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TP53I130.760.76
RFXANK0.740.69
CAPG0.740.67
AKR7A20.720.66
TMEM1490.720.68
TIMP10.700.72
CLIC10.690.63
TMEM179B0.690.67
TMEM2160.690.50
AL031319.20.690.56
Top 10 negatively co-expressed genes
FBXW7-0.50-0.61
AL031003.1-0.47-0.56
RAB11FIP4-0.47-0.57
TRIM44-0.46-0.54
ERC2-0.45-0.58
SCN2A-0.45-0.59
KIF3A-0.45-0.57
STXBP5-0.44-0.56
DNAJC6-0.44-0.56
MADD-0.44-0.56
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004871signal transducer activityIEA-
GO:0003924GTPase activityTAS2834384 
GO:0005515protein bindingIPI15537540 
GO:0005525GTP bindingIEA-
GO:0019001guanyl nucleotide bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007165signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005834heterotrimeric G-protein complexTAS3110783 
GO:0005886plasma membraneTAS3139448 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADCY5AC5adenylate cyclase 5-HPRD,BioGRID9748257 
ADRA2AADRA2 | ADRA2R | ADRAR | ALPHA2AAR | ZNF32adrenergic, alpha-2A-, receptor-HPRD11732925 
CD47IAP | MER6 | OA3CD47 molecule-HPRD11306274 
CNR1CANN6 | CB-R | CB1 | CB1A | CB1K5 | CB1R | CNRcannabinoid receptor 1 (brain)-HPRD,BioGRID11168387 
CRHR1CRF-R | CRF1 | CRFR1 | CRH-R1h | CRHR | CRHR1fcorticotropin releasing hormone receptor 1-HPRD,BioGRID10598591 
DRD3D3DR | ETM1 | FET1 | MGC149204 | MGC149205dopamine receptor D3-HPRD10978845 
EPORMGC138358erythropoietin receptorReconstituted ComplexBioGRID12538595 
FFAR1FFA1R | GPCR40 | GPR40free fatty acid receptor 1-HPRD,BioGRID12496284 |12629551 
GPR1-G protein-coupled receptor 1-HPRD14530282 
GPR143OA1G protein-coupled receptor 143-HPRD,BioGRID10471510 
GPSM1AGS3 | DKFZp727I051G-protein signaling modulator 1 (AGS3-like, C. elegans)Reconstituted ComplexBioGRID14530282 
GPSM2LGN | PinsG-protein signaling modulator 2 (AGS3-like, C. elegans)LGN interacts with Galphai1.BIND15537540 
GPSM3C6orf9 | G18 | G18.1a | G18.1b | G18.2 | NG1G-protein signaling modulator 3 (AGS3-like, C. elegans)-HPRD,BioGRID14656218 
HRH4AXOR35 | BG26 | GPCR105 | GPRv53 | H4 | H4R | HH4R | MGC133027histamine receptor H4-HPRD10973974 
HTR2A5-HT2A | HTR25-hydroxytryptamine (serotonin) receptor 2A-HPRD11916537 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptor-HPRD,BioGRID10644671 
NGB-neuroglobinReconstituted ComplexBioGRID12860983 
NUMA1NUMAnuclear mitotic apparatus protein 1NuMA interacts with Galphai1.BIND15537540 
OPRM1KIAA0403 | MOR | MOR1 | OPRMopioid receptor, mu 1-HPRD,BioGRID12068084 
RASD1AGS1 | DEXRAS1 | MGC:26290RAS, dexamethasone-induced 1in vitro
Reconstituted Complex		BioGRID10840027 |11842095 
RGS10-regulator of G-protein signaling 10-HPRD,BioGRID9207071 
RGS12DKFZp761K1617 | DKFZp761K1817regulator of G-protein signaling 12-HPRD,BioGRID11387333 
RGS14-regulator of G-protein signaling 14-HPRD,BioGRID11387333 |11976690 
RGS16A28-RGS14 | A28-RGS14P | RGS-Rregulator of G-protein signaling 16Biochemical ActivityBioGRID10878019 
RGS18RGS13regulator of G-protein signaling 18-HPRD,BioGRID11955952 
RGS19GAIP | RGSGAIPregulator of G-protein signaling 19-HPRD,BioGRID8986788 |10364213 
RGS4DKFZp761F1924 | MGC2124 | MGC60244 | RGP4 | SCZD9regulator of G-protein signaling 4-HPRD,BioGRID9660808 |11507164 
RGS5MST092 | MST106 | MST129 | MSTP032 | MSTP092 | MSTP106 | MSTP129regulator of G-protein signaling 5Affinity Capture-WesternBioGRID11253162 
RGS7-regulator of G-protein signaling 7-HPRD,BioGRID9572280 
RIC8AMGC104517 | MGC131931 | MGC148073 | MGC148074 | RIC8 | synembrynresistance to inhibitors of cholinesterase 8 homolog A (C. elegans)-HPRD,BioGRID12509430 
S1PR1CHEDG1 | D1S3362 | ECGF1 | EDG-1 | EDG1 | FLJ58121 | S1P1sphingosine-1-phosphate receptor 1-HPRD,BioGRID8626678 
S1PR2AGR16 | EDG-5 | EDG5 | Gpcr13 | H218 | LPB2 | S1P2sphingosine-1-phosphate receptor 2-HPRD10488065 
S1PR3EDG-3 | EDG3 | FLJ37523 | FLJ93220 | LPB3 | MGC71696 | S1P3sphingosine-1-phosphate receptor 3-HPRD10488065 
S1PR5EDG8 | Edg-8 | S1P5 | SPPR-1 | SPPR-2sphingosine-1-phosphate receptor 5-HPRD11069896 
SSTR2-somatostatin receptor 2-HPRD,BioGRID7914078 
SSTR3-somatostatin receptor 3-HPRD,BioGRID8183236 
STRNMGC125642 | SG2NAstriatin, calmodulin binding protein-HPRD15569929 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 8659All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
BIOCARTA_SPPA_PATHWAY 2218All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY 4535All SZGR genes in this pathway
BIOCARTA_CXCR4_PATHWAY 2422All SZGR genes in this pathway
BIOCARTA_MPR_PATHWAY 3428All SZGR genes in this pathway
BIOCARTA_GSK3_PATHWAY 2726All SZGR genes in this pathway
BIOCARTA_EDG1_PATHWAY 2724All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY 3731All SZGR genes in this pathway
BIOCARTA_PAR1_PATHWAY 3728All SZGR genes in this pathway
ST_ADRENERGIC 3629All SZGR genes in this pathway
ST_MYOCYTE_AD_PATHWAY 2725All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY 6352All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY 4135All SZGR genes in this pathway
PID_S1P_S1P3_PATHWAY 2924All SZGR genes in this pathway
PID_S1P_S1P4_PATHWAY 1411All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_S1P_S1P1_PATHWAY 2118All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 3529All SZGR genes in this pathway
PID_S1P_META_PATHWAY 2114All SZGR genes in this pathway
PID_AR_NONGENOMIC_PATHWAY 3127All SZGR genes in this pathway
PID_HEDGEHOG_GLI_PATHWAY 4835All SZGR genes in this pathway
PID_CXCR3_PATHWAY 4334All SZGR genes in this pathway
PID_THROMBIN_PAR1_PATHWAY 4332All SZGR genes in this pathway
PID_S1P_S1P2_PATHWAY 2419All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING 7856All SZGR genes in this pathway
REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY 139All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_PLC_BETA_MEDIATED_EVENTS 4332All SZGR genes in this pathway
REACTOME_G_PROTEIN_ACTIVATION 2715All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE 2515All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS 4429All SZGR genes in this pathway
REACTOME_SIGNAL_AMPLIFICATION 3119All SZGR genes in this pathway
REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 2110All SZGR genes in this pathway
REACTOME_GABA_B_RECEPTOR_ACTIVATION 3826All SZGR genes in this pathway
REACTOME_GABA_RECEPTOR_ACTIVATION 5240All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_UP 8554All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP 175108All SZGR genes in this pathway
AKL_HTLV1_INFECTION_UP 2716All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_GRANULOCYTE_UP 5534All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP 316190All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_UP 167All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_UP 14984All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
LANDIS_BREAST_CANCER_PROGRESSION_DN 7043All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_UP 12171All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_PRENEOPLASTIC_DN 5533All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_DN 14993All SZGR genes in this pathway
HU_ANGIOGENESIS_DN 3725All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_4NM_DN 76All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_UP 8351All SZGR genes in this pathway
WANG_RESPONSE_TO_BEXAROTENE_DN 2919All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN 382224All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
LE_EGR2_TARGETS_DN 10884All SZGR genes in this pathway
NADLER_OBESITY_DN 4834All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D4 5537All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN 228146All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN 312203All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C0 10772All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_DN 10864All SZGR genes in this pathway
LEE_RECENT_THYMIC_EMIGRANT 227128All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
CROONQUIST_NRAS_SIGNALING_DN 7247All SZGR genes in this pathway
VALK_AML_CLUSTER_10 3322All SZGR genes in this pathway
VALK_AML_WITH_EVI1 2515All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN 193112All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
ASGHARZADEH_NEUROBLASTOMA_POOR_SURVIVAL_DN 4630All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S2 11574All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_NEURAL 12985All SZGR genes in this pathway
BILANGES_SERUM_SENSITIVE_VIA_TSC1 2312All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
KOHOUTEK_CCNT2_TARGETS 5835All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/50616781684m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-18188941Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-195495551Ahsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-21818161822m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-3204264331A,m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-3844784841Ahsa-miR-384AUUCCUAGAAAUUGUUCAUA
miR-4482652721A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-485-3p174817551A,m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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