Gene Page: GNAO1

Summary
GeneID  2775
Symbol  GNAO1
Synonyms  DKFZp686O0962|G-ALPHA-o|GNAO
Description  guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
See related  HGNC:4389|MIM:139311|Ensembl:ENSG00000087258|HPRD:00757|
Locus tag  -
Gene type  protein-coding
Map location  16q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4488 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004871signal transducer activityIEA-
GO:0003924GTPase activityTAS1899283 
GO:0005525GTP bindingIEA-
GO:0019001guanyl nucleotide bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007212dopamine receptor signaling pathwayIEAdopamine (GO term level: 8)-
GO:0009987cellular processIEA-
GO:0007165signal transductionIEA-
GO:0008016regulation of heart contractionIEA-
GO:0007626locomotory behaviorIEA-
GO:0006936muscle contractionTAS9050846 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADORA1RDC7adenosine A1 receptor-HPRD10521440 
ADRA2AADRA2 | ADRA2R | ADRAR | ALPHA2AAR | ZNF32adrenergic, alpha-2A-, receptor-HPRD7887906 |11732925 
ADRA2CADRA2L2 | ADRA2RL2 | ADRARL2 | ALPHA2CARadrenergic, alpha-2C-, receptor-HPRD1349607 
CACNA1BBIII | CACNL1A5 | CACNN | Cav2.2calcium channel, voltage-dependent, N type, alpha 1B subunitReconstituted ComplexBioGRID11395521 
CRHR1CRF-R | CRF1 | CRFR1 | CRH-R1h | CRHR | CRHR1fcorticotropin releasing hormone receptor 1-HPRD,BioGRID10598591 
DCTN2DCTN50 | DYNAMITIN | RBP50dynactin 2 (p50)Two-hybridBioGRID16169070 
FFAR2FFA2R | GPR43free fatty acid receptor 2-HPRD12711604 
GPSM2LGN | PinsG-protein signaling modulator 2 (AGS3-like, C. elegans)-HPRD12925752 
HRH4AXOR35 | BG26 | GPCR105 | GPRv53 | H4 | H4R | HH4R | MGC133027histamine receptor H4-HPRD10973974 
HTR1F5-HT1F | 5HT6 | HTR1EL | MR775-hydroxytryptamine (serotonin) receptor 1F-HPRD11916537 
NGB-neuroglobinReconstituted ComplexBioGRID12860983 
OPRD1OPRDopioid receptor, delta 1-HPRD,BioGRID8393523 
OPRM1KIAA0403 | MOR | MOR1 | OPRMopioid receptor, mu 1-HPRD,BioGRID8393523 
PTPRUFLJ37530 | FMI | GLEPP1 | PCP-2 | PTP | PTP-J | PTP-PI | PTPPSI | PTPRO | PTPU2 | R-PTP-PSI | hPTP-Jprotein tyrosine phosphatase, receptor type, U-HPRD10196137 
RGS14-regulator of G-protein signaling 14-HPRD10926822 
RGS16A28-RGS14 | A28-RGS14P | RGS-Rregulator of G-protein signaling 16Reconstituted ComplexBioGRID9079700 
RGS19GAIP | RGSGAIPregulator of G-protein signaling 19-HPRD,BioGRID8986788 
RGS4DKFZp761F1924 | MGC2124 | MGC60244 | RGP4 | SCZD9regulator of G-protein signaling 4-HPRD,BioGRID9660808 
RGS5MST092 | MST106 | MST129 | MSTP032 | MSTP092 | MSTP106 | MSTP129regulator of G-protein signaling 5-HPRD,BioGRID9079700 
RGS7-regulator of G-protein signaling 7-HPRD,BioGRID9572280 
RIC8AMGC104517 | MGC131931 | MGC148073 | MGC148074 | RIC8 | synembrynresistance to inhibitors of cholinesterase 8 homolog A (C. elegans)-HPRD,BioGRID12509430 
S1PR5EDG8 | Edg-8 | S1P5 | SPPR-1 | SPPR-2sphingosine-1-phosphate receptor 5-HPRD11069896 
SCN8ACerIII | MED | NaCh6 | Nav1.6 | PN4sodium channel, voltage gated, type VIII, alpha subunit-HPRD,BioGRID10066808 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY 6352All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY 4135All SZGR genes in this pathway
PID_S1P_S1P3_PATHWAY 2924All SZGR genes in this pathway
PID_S1P_S1P4_PATHWAY 1411All SZGR genes in this pathway
PID_S1P_S1P1_PATHWAY 2118All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_S1P_META_PATHWAY 2114All SZGR genes in this pathway
PID_AR_NONGENOMIC_PATHWAY 3127All SZGR genes in this pathway
PID_HEDGEHOG_GLI_PATHWAY 4835All SZGR genes in this pathway
PID_CXCR3_PATHWAY 4334All SZGR genes in this pathway
PID_THROMBIN_PAR1_PATHWAY 4332All SZGR genes in this pathway
PID_S1P_S1P2_PATHWAY 2419All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING 7856All SZGR genes in this pathway
REACTOME_PLC_BETA_MEDIATED_EVENTS 4332All SZGR genes in this pathway
REACTOME_G_PROTEIN_ACTIVATION 2715All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE 2515All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_DN 2619All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_UP 14296All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_DN 165107All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_DN 180110All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN 181107All SZGR genes in this pathway
EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_UP 207128All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_DN 5437All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_VS_LOW_DN 3221All SZGR genes in this pathway
WATTEL_AUTONOMOUS_THYROID_ADENOMA_UP 7347All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
MA_MYELOID_DIFFERENTIATION_DN 4430All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
MCCLUNG_DELTA_FOSB_TARGETS_8WK 4738All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_2 8650All SZGR genes in this pathway
KAMMINGA_SENESCENCE 4126All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP 11687All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/1079349401Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-129-5p9939991Ahsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-134114211491A,m8hsa-miR-134brainUGUGACUGGUUGACCAGAGGG
miR-1391751811Ahsa-miR-139brainUCUACAGUGCACGUGUCU
hsa-miR-139brainUCUACAGUGCACGUGUCU
miR-181101310191Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-203.1115211581Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-218569575m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-30-5p102110281A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-326138144m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-330244250m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-5392342411A,m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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