Gene Page: GOT2

Summary
GeneID  2806
Symbol  GOT2
Synonyms  FLJ40994|KAT4|KATIV|mitAAT
Description  glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
See related  HGNC:4433|MIM:138150|Ensembl:ENSG00000125166|HPRD:00684|
Locus tag  -
Gene type  protein-coding
Map location  16q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KHDRBS30.810.87
VTA10.800.83
ARMCX10.800.83
RFWD20.800.82
PPAPR50.800.86
TMEM50A0.790.79
NELL20.790.85
PPP3CC0.790.81
ASNSD10.790.79
POLR2B0.780.80
Top 10 negatively co-expressed genes
PAQR6-0.66-0.77
MT-CO2-0.66-0.71
AF347015.33-0.66-0.71
FXYD1-0.65-0.73
HSD17B14-0.65-0.72
S100B-0.65-0.72
HEPN1-0.64-0.69
HLA-F-0.64-0.70
AF347015.26-0.64-0.72
TSC22D4-0.63-0.72
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004069aspartate transaminase activityEXPglutamate (GO term level: 6)4052435 
GO:0004069aspartate transaminase activityIDAglutamate (GO term level: 6)2182221 |2567216 |2731362 
GO:0030170pyridoxal phosphate bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006520amino acid metabolic processIEA-
GO:0006533aspartate catabolic processIDA2567216 
GO:0009058biosynthetic processIEA-
GO:0015908fatty acid transportIEP9537447 
GO:0045471response to ethanolIDA9537447 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005739mitochondrionIDA9537447 
GO:0005743mitochondrial inner membraneIEA-
GO:0005759mitochondrial matrixEXP4052435 
GO:0005759mitochondrial matrixIEA-
GO:0005886plasma membraneIDA9537447 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CTNNBIP1ICAT | MGC15093catenin, beta interacting protein 1Affinity Capture-MSBioGRID17353931 
GLUD1GDH | GDH1 | GLUD | MGC132003glutamate dehydrogenase 1-HPRD3997814 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD,BioGRID7559589 
MDH2M-MDH | MDH | MGC:3559 | MOR1malate dehydrogenase 2, NAD (mitochondrial)-HPRD2899080 
MPGAAG | APNG | CRA36.1 | MDG | Mid1 | PIG11 | PIG16 | anpgN-methylpurine-DNA glycosylaseAffinity Capture-MSBioGRID17353931 
THOC7FLJ23445 | NIF3L1BP1 | fSAP24THO complex 7 homolog (Drosophila)Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM 3226All SZGR genes in this pathway
KEGG_CYSTEINE_AND_METHIONINE_METABOLISM 3424All SZGR genes in this pathway
KEGG_ARGININE_AND_PROLINE_METABOLISM 5439All SZGR genes in this pathway
KEGG_TYROSINE_METABOLISM 4230All SZGR genes in this pathway
KEGG_PHENYLALANINE_METABOLISM 1812All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_GLUCONEOGENESIS 3421All SZGR genes in this pathway
REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION 1714All SZGR genes in this pathway
REACTOME_METABOLISM_OF_CARBOHYDRATES 247154All SZGR genes in this pathway
REACTOME_GLUCOSE_METABOLISM 6942All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
PROVENZANI_METASTASIS_UP 194112All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_UP 6344All SZGR genes in this pathway
AIYAR_COBRA1_TARGETS_DN 2918All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP 201127All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_DN 245154All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 6348All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN 8757All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_DN 8759All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
JIANG_HYPOXIA_CANCER 8352All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_MACROPHAGE 7750All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_UP 388234All SZGR genes in this pathway
WONG_MITOCHONDRIA_GENE_MODULE 217122All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_BPA 5135All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G123_DN 5130All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_DN 8054All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-30-5p2552611Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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