Gene Page: GRIK2

Summary
GeneID  2898
Symbol  GRIK2
Synonyms  EAA4|GLR6|GLUK6|GLUR6|MGC74427|MRT6
Description  glutamate receptor, ionotropic, kainate 2
See related  HGNC:4580|MIM:138244|Ensembl:ENSG00000164418|HPRD:00692|
Locus tag  -
Gene type  protein-coding
Map location  6q16.3-q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 7 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 15.5 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MTMR90.880.93
NRXN10.880.92
CPEB40.880.92
KIAA03170.880.93
INPP4A0.880.92
GABRB30.870.92
ATRN0.870.92
AVL90.870.92
GNAQ0.870.91
ATP9A0.870.92
Top 10 negatively co-expressed genes
AF347015.31-0.65-0.74
FXYD1-0.65-0.71
MT-CO2-0.64-0.75
HIGD1B-0.63-0.74
AC021016.1-0.63-0.71
AF347015.33-0.63-0.69
COPZ2-0.62-0.67
AF347015.8-0.62-0.73
MT-CYB-0.62-0.70
AF347015.27-0.62-0.70
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005234extracellular-glutamate-gated ion channel activityIEAglutamate (GO term level: 11)-
GO:0015277kainate selective glutamate receptor activityIDAglutamate (GO term level: 8)15537878 
GO:0004872receptor activityIEA-
GO:0005216ion channel activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048172regulation of short-term neuronal synaptic plasticityIMPneuron, Synap (GO term level: 10)15537878 
GO:0007215glutamate signaling pathwayTASglutamate (GO term level: 7)7536611 
GO:0050806positive regulation of synaptic transmissionIMPneuron, Synap (GO term level: 9)15537878 
GO:0051402neuron apoptosisIDAneuron, axon, dendrite (GO term level: 7)15537878 
GO:0006811ion transportIEA-
GO:0031557induction of programmed cell death in response to chemical stimulusNAS15537878 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS7536611 
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CASKCAGH39 | CMG | FLJ22219 | FLJ31914 | LIN2 | MICPCH | TNRC8calcium/calmodulin-dependent serine protein kinase (MAGUK family)-HPRD12151522 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)-HPRD12151522 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD12151522 
CTNND1CAS | CTNND | KIAA0384 | P120CAS | P120CTN | p120catenin (cadherin-associated protein), delta 1-HPRD12151522 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD,BioGRID11279111 
DLG3KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102discs, large homolog 3 (neuroendocrine-dlg, Drosophila)-HPRD12070168 
Affinity Capture-WesternBioGRID9808460 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD9808460 |11276111 
|12597860 
Affinity Capture-Western
Reconstituted Complex		BioGRID9808460 |11279111 
|12597860 
GRIA1GLUH1 | GLUR1 | GLURA | HBGR1 | MGC133252glutamate receptor, ionotropic, AMPA 1Affinity Capture-WesternBioGRID8288598 
-HPRD10358037 
GRIA2GLUR2 | GLURB | GluR-K2 | HBGR2glutamate receptor, ionotropic, AMPA 2Affinity Capture-WesternBioGRID8288598 
GRID2MGC117022 | MGC117023 | MGC117024glutamate receptor, ionotropic, delta 2Affinity Capture-WesternBioGRID12573530 
GluR6 interacts with GluR-delta-2BIND12573530 
GRIK4EAA1 | GRIK | KA1glutamate receptor, ionotropic, kainate 4-HPRD8288598 |12954862 
GRIK5EAA2 | GRIK2 | KA2glutamate receptor, ionotropic, kainate 5-HPRD,BioGRID9466455 
GRIP1GRIPglutamate receptor interacting protein 1Reconstituted ComplexBioGRID11891216 |12597860 
PICK1MGC15204 | PICK | PRKCABPprotein interacting with PRKCA 1-HPRD,BioGRID12597860 
SDCBPMDA-9 | ST1 | SYCL | TACIP18syndecan binding protein (syntenin)-HPRD,BioGRID12597860 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING 3123All SZGR genes in this pathway
REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS 1111All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN 148102All SZGR genes in this pathway
ULE_SPLICING_VIA_NOVA2 4338All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN 228114All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP 10264All SZGR genes in this pathway
NUTT_GBM_VS_AO_GLIOMA_DN 4522All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_UP 5541All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP 13993All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/981051111Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-15377831Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-181246252m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-217282288m8hsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-21821281A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-36387931Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-3761221291A,m8hsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-44876831A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-4946167m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-5435965m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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