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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: GRIN1

Summary

GeneID

2902

Symbol

GRIN1

Synonyms

NMDA1|NMDAR1|NR1

Description

glutamate receptor, ionotropic, N-methyl D-aspartate 1

Locus tag

Gene type

protein-coding

Map location

9q34.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Association

A combined odds ratio method (Sun et al. 2008), association studies

Link to SZGene

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 15

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 7.9864

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

AC021914.1

0.74

0.28

CLEC2B

0.64

0.35

CXCL2

0.61

0.53

AL050337.1

0.57

0.18

AC137766.1

0.56

0.37

C1orf61

0.55

0.34

C17orf84

0.54

0.03

OASL

0.53

0.33

C1orf54

0.52

0.31

IFITM1

0.51

0.47

Top 10 negatively co-expressed genes

DNAJC7

-0.51

-0.38

CHMP4B

-0.50

-0.35

ARFGAP2

-0.50

-0.40

NUDC

-0.49

-0.40

NDUFS2

-0.48

-0.36

UBE2Q1

-0.48

-0.37

GRPEL1

-0.48

-0.40

C20orf43

-0.47

-0.36

SPG7

-0.47

-0.29

MRPS5

-0.47

-0.41

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004972

N-methyl-D-aspartate selective glutamate receptor activity

IDA

glutamate (GO term level: 8)

7679115 |7685113

GO:0004970

ionotropic glutamate receptor activity

IEA

glutamate (GO term level: 7)

GO:0005234

extracellular-glutamate-gated ion channel activity

IEA

glutamate (GO term level: 11)

GO:0016595

glutamate binding

IDA

glutamate (GO term level: 5)

7685113

GO:0035254

glutamate receptor binding

ISS

glutamate (GO term level: 5)

GO:0000287

magnesium ion binding

IEA

GO:0004872

receptor activity

IEA

GO:0005509

calcium ion binding

ISS

GO:0005516

calmodulin binding

ISS

GO:0005262

calcium channel activity

IDA

7685113

GO:0005216

ion channel activity

IEA

GO:0016594

glycine binding

IDA

7685113

GO:0016594

glycine binding

IMP

17047094

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0060079

regulation of excitatory postsynaptic membrane potential

ISS

neuron, Synap (GO term level: 10)

GO:0007268

synaptic transmission

ISS

neuron, Synap, Neurotransmitter (GO term level: 6)

GO:0035235

ionotropic glutamate receptor signaling pathway

ISS

glutamate (GO term level: 8)

GO:0008542

visual learning

ISS

GO:0006811

ion transport

IEA

GO:0006812

cation transport

IDA

7685113

GO:0042391

regulation of membrane potential

IDA

7679115 |7685113 |17047094

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

ISS

GO:0045471

response to ethanol

IDA

18445116

GO:0055074

calcium ion homeostasis

ISS

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0008021

synaptic vesicle

ISS

Synap, Neurotransmitter (GO term level: 12)

GO:0014069

postsynaptic density

ISS

Synap (GO term level: 10)

GO:0019717

synaptosome

ISS

Synap, Brain (GO term level: 7)

GO:0017146

N-methyl-D-aspartate selective glutamate receptor complex

IDA

glutamate, Synap (GO term level: 10)

7679115 |10480938 |17047094

GO:0030425

dendrite

IDA

neuron, axon, dendrite (GO term level: 6)

10749211

GO:0045211

postsynaptic membrane

IEA

Synap, Neurotransmitter (GO term level: 5)

GO:0045211

postsynaptic membrane

ISS

Synap, Neurotransmitter (GO term level: 5)

GO:0045202

synapse

IEA

neuron, Synap, Neurotransmitter, Glial (GO term level: 2)

GO:0045202

synapse

ISS

neuron, Synap, Neurotransmitter, Glial (GO term level: 2)

GO:0016021

integral to membrane

IEA

GO:0005886

plasma membrane

IEA

GO:0005887

integral to plasma membrane

IDA

7685113

GO:0030054

cell junction

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTN2	CMD1AA	actinin, alpha 2	-	HPRD	9009191 \|9728925 \|9952395
ACTN2	CMD1AA	actinin, alpha 2	alpha-actinin-2 interacts with NR1A. This interaction was modeled on a demonstrated interaction between human alpha-actinin-2 and NR1A from an unspecified species.	BIND	9009191
AKAP9	AKAP350 \| AKAP450 \| CG-NAP \| HYPERION \| KIAA0803 \| MU-RMS-40.16A \| PRKA9 \| YOTIAO	A kinase (PRKA) anchor protein (yotiao) 9	-	HPRD	9482789\|10862698
AKAP9		A kinase (PRKA) anchor protein (yotiao) 9	-	HPRD	10862698
CACNG2	MGC138502 \| MGC138504	calcium channel, voltage-dependent, gamma subunit 2	Co-fractionation	BioGRID	11140673
CAMK2A	CAMKA \| KIAA0968	calcium/calmodulin-dependent protein kinase II alpha	-	HPRD	10862698
CANX	CNX \| FLJ26570 \| IP90 \| P90	calnexin	-	HPRD	11506858 \|14732708
CDH2	CD325 \| CDHN \| CDw325 \| NCAD	cadherin 2, type 1, N-cadherin (neuronal)	-	HPRD	10862698
CIT	CRIK \| KIAA0949 \| STK21	citron (rho-interacting, serine/threonine kinase 21)	-	HPRD	10862698
CLTC	CHC \| CHC17 \| CLH-17 \| CLTCL2 \| Hc \| KIAA0034	clathrin, heavy chain (Hc)	-	HPRD	10862698
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	-	HPRD	10862698
DLG2	DKFZp781D1854 \| DKFZp781E0954 \| FLJ37266 \| MGC131811 \| PSD-93	discs, large homolog 2, chapsyn-110 (Drosophila)	-	HPRD	10862698
DLG3	KIAA1232 \| MRX \| MRX90 \| NE-Dlg \| NEDLG \| SAP102	discs, large homolog 3 (neuroendocrine-dlg, Drosophila)	-	HPRD	10862698
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	-	HPRD	9009191 \|9502803 \|11506858 \|12068077 \|14732708 \|15030493
DLGAP4	DAP4 \| KIAA0964 \| MGC131862 \| RP5-977B1.6 \| SAPAP4	discs, large (Drosophila) homolog-associated protein 4	-	HPRD	10862698
DNM1	DNM	dynamin 1	-	HPRD	10862698
DRD1	DADR \| DRD1A	dopamine receptor D1	-	HPRD	12408866
DUSP4	HVH2 \| MKP-2 \| MKP2 \| TYP	dual specificity phosphatase 4	-	HPRD	10862698
EPHB2	CAPB \| DRT \| EPHT3 \| ERK \| Hek5 \| MGC87492 \| PCBC \| Tyro5	EPH receptor B2	-	HPRD	11754835
EPHB4	HTK \| MYK1 \| TYRO11	EPH receptor B4	-	HPRD	11136979
FUS	CHOP \| FUS-CHOP \| FUS1 \| TLS \| TLS/CHOP \| hnRNP-P2	fusion (involved in t(12;16) in malignant liposarcoma)	-	HPRD	10862698
GRIN2A	NMDAR2A \| NR2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	NR1a interacts with NR2A.	BIND	11279200
			-	HPRD	8139656 \|10862698 \|11803122 \|12068077 \|12191494 \|12893641 \|14732708
			Affinity Capture-Western	BioGRID	12391275
GRIN2B	MGC142178 \| MGC142180 \| NMDAR2B \| NR2B \| hNR3	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	Affinity Capture-Western	BioGRID	12391275
GRIN2B	MGC142178 \| MGC142180 \| NMDAR2B \| NR2B \| hNR3	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	-	HPRD	8139656 \|12191494 \|15030493
GRIN2D	EB11 \| NMDAR2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	-	HPRD	12191494
GRIN3A	FLJ45414 \| NMDAR-L \| NR3A	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	Affinity Capture-Western	BioGRID	12391275
GRIN3A	FLJ45414 \| NMDAR-L \| NR3A	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	-	HPRD	9620802 \|11160393 \|11588171
GRIN3B	NR3B	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	Affinity Capture-Western	BioGRID	12008020
HNRNPU	HNRPU \| SAF-A \| U21.1	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	-	HPRD	10862698
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	-	HPRD	10862698
HSPA1A	FLJ54303 \| FLJ54370 \| FLJ54392 \| FLJ54408 \| FLJ75127 \| HSP70-1 \| HSP70-1A \| HSP70I \| HSP72 \| HSPA1 \| HSPA1B	heat shock 70kDa protein 1A	-	HPRD	10862698
INA	FLJ18662 \| FLJ57501 \| MGC12702 \| NEF5 \| NF-66 \| TXBP-1	internexin neuronal intermediate filament protein, alpha	-	HPRD	10862698
KAT5	ESA1 \| HTATIP \| HTATIP1 \| PLIP \| TIP \| TIP60 \| cPLA2	K(lysine) acetyltransferase 5	-	HPRD	10862698
MAP2	DKFZp686I2148 \| MAP2A \| MAP2B \| MAP2C	microtubule-associated protein 2	-	HPRD	10862698
MAP2K2	FLJ26075 \| MAPKK2 \| MEK2 \| MKK2 \| PRKMK2	mitogen-activated protein kinase kinase 2	-	HPRD	10862698
MYH9	DFNA17 \| EPSTS \| FTNS \| MGC104539 \| MHA \| NMHC-II-A \| NMMHCA	myosin, heavy chain 9, non-muscle	-	HPRD	10862698
NANOS1	NOS1	nanos homolog 1 (Drosophila)	-	HPRD	10862698
ND2	MTND2	NADH dehydrogenase, subunit 2 (complex I)	Affinity Capture-Western	BioGRID	15069201
NEFL	CMT1F \| CMT2E \| FLJ53642 \| NF-L \| NF68 \| NFL	neurofilament, light polypeptide	-	HPRD	9425014
NF1	DKFZp686J1293 \| FLJ21220 \| NFNS \| VRNF \| WSS	neurofibromin 1	-	HPRD	10862698
PLAT	DKFZp686I03148 \| T-PA \| TPA	plasminogen activator, tissue	-	HPRD	15448144
PPP2R1A	MGC786 \| PR65A	protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform	-	HPRD	10862698
PPP2R2A	B55-ALPHA \| B55A \| FLJ26613 \| MGC52248 \| PR52A \| PR55A	protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform	-	HPRD	10862698
PRKCB	MGC41878 \| PKC-beta \| PKCB \| PRKCB1 \| PRKCB2	protein kinase C, beta	-	HPRD	10862698
PRKCE	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	-	HPRD	10862698
PRKCG	MGC57564 \| PKC-gamma \| PKCC \| PKCG \| SCA14	protein kinase C, gamma	-	HPRD	10862698
RAP2A	K-REV \| KREV \| RAP2 \| RbBP-30	RAP2A, member of RAS oncogene family	-	HPRD	10862698
RPS6KA3	CLS \| HU-3 \| ISPK-1 \| MAPKAPK1B \| MRX19 \| RSK \| RSK2 \| S6K-alpha3 \| p90-RSK2 \| pp90RSK2	ribosomal protein S6 kinase, 90kDa, polypeptide 3	-	HPRD	10862698
SP1	-	Sp1 transcription factor	-	HPRD	14970236
SP3	DKFZp686O1631 \| SPR-2	Sp3 transcription factor	-	HPRD	14970236
SPTAN1	(ALPHA)II-SPECTRIN \| FLJ44613 \| NEAS	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	-	HPRD	9670010 \|10862698
SYNGAP1	DKFZp761G1421 \| KIAA1938 \| RASA1 \| RASA5 \| SYNGAP	synaptic Ras GTPase activating protein 1 homolog (rat)	-	HPRD	10862698
TIAM1	FLJ36302	T-cell lymphoma invasion and metastasis 1	Tiam1 interacts with NMDA subunit NR1. This interaction was modelled on a demonstrated interaction between human Tiam1 and NR1 from an unspecified species.	BIND	15721239
TJP1	DKFZp686M05161 \| MGC133289 \| ZO-1	tight junction protein 1 (zona occludens 1)	-	HPRD	10862698
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF receptor-associated factor 3	-	HPRD	10862698
TUBA4B	FLJ13940 \| TUBA4	tubulin, alpha 4b (pseudogene)	-	HPRD	10862698

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_CALCIUM_SIGNALING_PATHWAY	178	134	All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	272	195	All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION	70	57	All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE	169	110	All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS	53	43	All SZGR genes in this pathway
KEGG_HUNTINGTONS_DISEASE	185	109	All SZGR genes in this pathway
BIOCARTA_EPONFKB_PATHWAY	11	11	All SZGR genes in this pathway
BIOCARTA_NOS1_PATHWAY	24	21	All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	186	155	All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM	279	221	All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL	137	110	All SZGR genes in this pathway
REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR	17	15	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS	37	32	All SZGR genes in this pathway
REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS	27	23	All SZGR genes in this pathway
REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS	33	28	All SZGR genes in this pathway
REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION	15	14	All SZGR genes in this pathway
REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII	15	14	All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_DN	186	107	All SZGR genes in this pathway
EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_UP	207	128	All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3	1118	744	All SZGR genes in this pathway
CHIARETTI_ACUTE_LYMPHOBLASTIC_LEUKEMIA_ZAP70	67	33	All SZGR genes in this pathway
MCCLUNG_DELTA_FOSB_TARGETS_8WK	47	38	All SZGR genes in this pathway
ULE_SPLICING_VIA_NOVA2	43	38	All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN	88	58	All SZGR genes in this pathway
MARIADASON_RESPONSE_TO_BUTYRATE_SULINDAC_6	52	32	All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_UP	181	112	All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP	210	124	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3	341	243	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN	222	147	All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP	857	456	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-15/16/195/424/497	58	64	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-214	56	62	m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.