Gene Page: APBB2

Summary
GeneID  323
Symbol  APBB2
Synonyms  DKFZp434E033|FE65L|FE65L1|MGC35575
Description  amyloid beta (A4) precursor protein-binding, family B, member 2
See related  HGNC:582|MIM:602710|Ensembl:ENSG00000163697|HPRD:04088|
Locus tag  -
Gene type  protein-coding
Map location  4p14-p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AL360181.50.490.40
PCBP30.490.38
ESYT30.490.41
ABCA70.480.42
KCNH60.480.41
SPTBN50.480.40
SOX130.470.46
MYH150.460.45
EPS8L20.460.45
SPATA200.460.40
Top 10 negatively co-expressed genes
PPAPR5-0.25-0.21
ZNF238-0.25-0.19
NEUROD6-0.25-0.26
KLHL1-0.25-0.17
RPL5-0.24-0.25
RPL35A-0.24-0.34
DACT1-0.24-0.17
RPL38-0.24-0.35
GPR22-0.24-0.22
AC005768.1-0.24-0.20
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001540beta-amyloid bindingISS-
GO:0008134transcription factor bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007242intracellular signaling cascadeNAS8855266 
GO:0007050cell cycle arrestISS-
GO:0030308negative regulation of cell growthISS-
GO:0045749negative regulation of S phase of mitotic cell cycleISS-
GO:0045449regulation of transcriptionISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030426growth coneISSaxon, dendrite (GO term level: 5)-
GO:0045202synapseISSneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005634nucleusISS-
GO:0016020membraneNAS8855266 
GO:0030027lamellipodiumISS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APLP2APPH | APPL2 | CDEBPamyloid beta (A4) precursor-like protein 2-HPRD8855266 
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor protein-HPRD,BioGRID8855266 |14527950 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP 183119All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_UP 7848All SZGR genes in this pathway
PEPPER_CHRONIC_LYMPHOCYTIC_LEUKEMIA_DN 218All SZGR genes in this pathway
HUMMEL_BURKITTS_LYMPHOMA_UP 4327All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_DN 12984All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_DN 209122All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_WITH_7Q_DELETION_DN 3623All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN 8871All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
YANG_BREAST_CANCER_ESR1_UP 3622All SZGR genes in this pathway
YANG_BREAST_CANCER_ESR1_LASER_UP 3425All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_MODERATELY_DN 11064All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_UP 5735All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN 162102All SZGR genes in this pathway
PETROVA_PROX1_TARGETS_DN 6438All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
LEE_AGING_MUSCLE_DN 4629All SZGR genes in this pathway
MARIADASON_RESPONSE_TO_BUTYRATE_SULINDAC_4 2112All SZGR genes in this pathway
BURTON_ADIPOGENESIS_7 5134All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
KONDO_EZH2_TARGETS 245148All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP 12589All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
TOOKER_GEMCITABINE_RESISTANCE_DN 12284All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_UP 13485All SZGR genes in this pathway
KIM_PTEN_TARGETS_UP 189All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1795801m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5067958011Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-141/200a1311381A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-1539139191Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d409415m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-228138191Ahsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-311571641A,m8hsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-33097103m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-4489129191A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-542-3p3813881A,m8hsa-miR-542-3pUGUGACAGAUUGAUAACUGAAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.