Gene Page: APOA1

Summary
GeneID  335
Symbol  APOA1
Synonyms  MGC117399
Description  apolipoprotein A-I
See related  HGNC:600|MIM:107680|Ensembl:ENSG00000118137|HPRD:02517|
Locus tag  -
Gene type  protein-coding
Map location  11q23-q24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.3212 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PRPS20.710.76
OXCT10.700.78
LRRC4C0.690.78
PAK60.680.79
DLG20.680.71
FAM102B0.680.73
CDH100.670.75
TMEM1960.670.65
PLCH10.660.77
LANCL20.660.73
Top 10 negatively co-expressed genes
IMPA2-0.38-0.46
IRF7-0.35-0.41
RAB13-0.34-0.44
NUDT8-0.34-0.32
AP002478.3-0.33-0.36
TEAD4-0.33-0.38
SLC25A20-0.32-0.28
ACSF2-0.32-0.31
DCI-0.32-0.35
RHBDL3-0.31-0.32
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001540beta-amyloid bindingIDA11297421 
GO:0005543phospholipid bindingIDA12810715 
GO:0005319lipid transporter activityIEA-
GO:0008289lipid bindingIEA-
GO:0017127cholesterol transporter activityIDA9651324 
GO:0017127cholesterol transporter activityIMP15464323 
GO:0015485cholesterol bindingIDA15464323 
GO:0042802identical protein bindingIPI8049247 
GO:0019899enzyme bindingIPI1587806 
GO:0034191apolipoprotein A-I receptor bindingIPI16443932 
GO:0060228phosphatidylcholine-sterol O-acyltransferase activator activityIDA4335615 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002740negative regulation of cytokine secretion during immune responseIDA12458630 
GO:0007186G-protein coupled receptor protein signaling pathwayIDA16443932 
GO:0008202steroid metabolic processIEA-
GO:0008203cholesterol metabolic processIEA-
GO:0006656phosphatidylcholine biosynthetic processIDA4335615 
GO:0006629lipid metabolic processIEA-
GO:0006869lipid transportIEA-
GO:0033344cholesterol effluxIDA11162594 |14703508 |16443932 
GO:0042157lipoprotein metabolic processIEA-
GO:0050821protein stabilizationIDA17655203 
GO:0034435cholesterol esterificationIDA4335615 
GO:0032488Cdc42 protein signal transductionIDA16443932 
GO:0033700phospholipid effluxIDA11162594 |14703508 
GO:0042632cholesterol homeostasisIMP15464323 
GO:0050713negative regulation of interleukin-1 beta secretionIDA12458630 
GO:0043691reverse cholesterol transportIMP15464323 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005788endoplasmic reticulum lumenEXP12692552 
GO:0005576extracellular regionEXP4345202 |12692552 
GO:0005576extracellular regionIEA-
GO:0030139endocytic vesicleIDA14747463 
GO:0031410cytoplasmic vesicleIDA14703508 
GO:0034364high-density lipoprotein particleIDA210174 |3104518 |15464323 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABCA1ABC-1 | ABC1 | CERP | FLJ14958 | HDLDT1 | MGC164864 | MGC165011 | TGDATP-binding cassette, sub-family A (ABC1), member 1Reconstituted ComplexBioGRID12084722 
APOA1MGC117399apolipoprotein A-I-HPRD,BioGRID9003180 |9200714 
|9356442 
APOA1BPAIBP | MGC119143 | MGC119144 | MGC119145 | YJEFN1apolipoprotein A-I binding protein-HPRD11991719 
APOFApo-F | DKFZp781G18150 | LTIP | MGC22520apolipoprotein FCo-purificationBioGRID6816269 
APOL1APO-L | APOL | APOL-Iapolipoprotein L, 1-HPRD,BioGRID9325276 
GPLD1GPIPLD | GPIPLDM | MGC22590 | PIGPLD | PIGPLD1glycosylphosphatidylinositol specific phospholipase D1-HPRD,BioGRID11254757 
HPRA-259H10.2 | HPhaptoglobin-related proteinin vitroBioGRID10085035 
LBPMGC22233lipopolysaccharide binding proteinAffinity Capture-WesternBioGRID8663389 
LCAT-lecithin-cholesterol acyltransferaseReconstituted ComplexBioGRID1644835 
MAP7D1FLJ10350 | FLJ39022 | MGC117315 | PARCC1 | RPRC1MAP7 domain containing 1Two-hybridBioGRID16169070 
PDE1AHCAM1 | HSPDE1A | MGC26303phosphodiesterase 1A, calmodulin-dependentTwo-hybridBioGRID11991719 
PLTPHDLCQ9phospholipid transfer proteinCo-purification
Reconstituted Complex		BioGRID9469594 
-HPRD11854286 
SCARB1CD36L1 | CLA-1 | CLA1 | MGC138242 | SR-BI | SRB1scavenger receptor class B, member 1in vivoBioGRID1076467 
TNFRSF10CCD263 | DCR1 | LIT | MGC149501 | MGC149502 | TRAILR3 | TRIDtumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domainTwo-hybridBioGRID16169070 
TOMM20KIAA0016 | MAS20 | MGC117367 | MOM19 | TOM20translocase of outer mitochondrial membrane 20 homolog (yeast)Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PPAR_SIGNALING_PATHWAY 6947All SZGR genes in this pathway
BIOCARTA_PPARA_PATHWAY 5843All SZGR genes in this pathway
PID_HNF3B_PATHWAY 4537All SZGR genes in this pathway
REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS 1811All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 10472All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_HDL_MEDIATED_LIPID_TRANSPORT 1512All SZGR genes in this pathway
REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT 3421All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 4637All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_LIPOPROTEIN_METABOLISM 2824All SZGR genes in this pathway
REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT 1615All SZGR genes in this pathway
REACTOME_AMYLOIDS 8363All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
KORKOLA_YOLK_SAC_TUMOR 6233All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_2 11476All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
NIELSEN_LIPOSARCOMA_UP 1813All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
CADWELL_ATG16L1_TARGETS_UP 9356All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_UP 13485All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
VANDESLUIS_COMMD1_TARGETS_GROUP_4_UP 1912All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP 271165All SZGR genes in this pathway


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