Gene Page: KLK3

Summary
GeneID  354
Symbol  KLK3
Synonyms  APS|KLK2A1|PSA|hK3
Description  kallikrein-related peptidase 3
See related  HGNC:6364|MIM:176820|Ensembl:ENSG00000142515|HPRD:01461|
Locus tag  -
Gene type  protein-coding
Map location  19q13.41
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ATP9A0.850.86
PCDH100.830.85
PYGO20.820.82
ARL4C0.820.85
SRGAP30.810.85
TMEM1270.810.85
ARHGEF70.810.86
KLHL180.810.83
FNIP20.800.85
DCBLD20.800.83
Top 10 negatively co-expressed genes
MT-CO2-0.62-0.69
AF347015.31-0.61-0.67
FXYD1-0.60-0.64
AF347015.21-0.60-0.70
AF347015.33-0.59-0.62
AF347015.8-0.58-0.66
MT-CYB-0.58-0.64
HIGD1B-0.57-0.63
AC021016.1-0.57-0.62
AF347015.27-0.57-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0004252serine-type endopeptidase activityNASglutamate (GO term level: 7)-
GO:0003824catalytic activityIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0006508proteolysisNAS-
GO:0016525negative regulation of angiogenesisNAS10675891 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS14718574 
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
A2MCPAMD5 | DKFZp779B086 | FWP007 | S863-7alpha-2-macroglobulin-HPRD8583572 
Affinity Capture-WesternBioGRID1702714 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorAR interacts with p-PSA.BIND15542435 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaCTNNB1 (beta-catenin) interacts with the KLK3 (PSA) promoter.BIND15829968 
EPORMGC138358erythropoietin receptor-HPRD10374881 
FN1CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSFfibronectin 1-HPRD9016396 
IGFBP3BP-53 | IBP3insulin-like growth factor binding protein 3-HPRD,BioGRID1383255 |10511594 
KAT5ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2K(lysine) acetyltransferase 5HTATIP (Tip60) interacts with the KLK3 (PSA) promoter.BIND15829968 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaPol II interacts with p-PSA.BIND15542435 
PZPCPAMD6 | MGC133093pregnancy-zone protein-HPRD1702714 
RUVBL1ECP54 | INO80H | NMP238 | PONTIN | Pontin52 | RVB1 | TIH1 | TIP49 | TIP49ARuvB-like 1 (E. coli)RUVBL1 (pontin) interacts with the KLK3 (PSA) promoter.BIND15829968 
SERPINA1A1A | A1AT | AAT | MGC23330 | MGC9222 | PI | PI1 | PRO2275serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1Affinity Capture-WesternBioGRID1702714 
SERPINA3AACT | ACT | GIG24 | GIG25 | MGC88254serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3-HPRD8732755 |9261179 
|10759471 |11317942 
|11735417 
SERPINA5PAI3 | PCI | PLANH3 | PROCIserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5-HPRD,BioGRID7509746 |8665956 
|8732755 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PID_AR_TF_PATHWAY 5338All SZGR genes in this pathway
PID_HNF3A_PATHWAY 4429All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS 1612All SZGR genes in this pathway
WANG_RESPONSE_TO_ANDROGEN_UP 2921All SZGR genes in this pathway
WANG_RESPONSE_TO_FORSKOLIN_UP 2317All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN 352225All SZGR genes in this pathway
GOERING_BLOOD_HDL_CHOLESTEROL_QTL_TRANS 147All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
RADAEVA_RESPONSE_TO_IFNA1_UP 5240All SZGR genes in this pathway
NELSON_RESPONSE_TO_ANDROGEN_UP 8661All SZGR genes in this pathway
YEGNASUBRAMANIAN_PROSTATE_CANCER 12860All SZGR genes in this pathway
OSADA_ASCL1_TARGETS_UP 4630All SZGR genes in this pathway
CHNG_MULTIPLE_MYELOMA_HYPERPLOID_UP 5225All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_UP 185112All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway


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