Gene Page: IL6R

Summary
GeneID  3570
Symbol  IL6R
Synonyms  CD126|IL-6R-1|IL-6R-alpha|IL6RA|MGC104991
Description  interleukin 6 receptor
See related  HGNC:6019|MIM:147880|Ensembl:ENSG00000160712|HPRD:01000|
Locus tag  -
Gene type  protein-coding
Map location  1q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AC012652.10.770.81
ARHGEF30.760.80
LRRC20.740.82
FAM19A10.740.81
RIMBP20.730.76
RAPGEFL10.730.81
RP4-788L13.10.720.70
P4HA20.720.78
DLG20.720.68
GARNL40.720.73
Top 10 negatively co-expressed genes
IMPA2-0.41-0.47
SORBS3-0.38-0.41
FAM181B-0.37-0.44
MAPKAPK3-0.36-0.34
RAB13-0.36-0.50
AF347015.18-0.35-0.24
PECI-0.35-0.38
ACSF2-0.35-0.32
AF347015.26-0.35-0.21
AF347015.21-0.34-0.19
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004896cytokine receptor activityIEA-
GO:0004915interleukin-6 receptor activityTAS2261637 
GO:0019899enzyme bindingIPI12748171 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007166cell surface receptor linked signal transductionTAS3136546 
GO:0008283cell proliferationTAS3136546 
GO:0006955immune responseTAS3136546 
GO:0007275multicellular organismal developmentTAS3136546 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIDA12748171 
GO:0005896interleukin-6 receptor complexTAS3136546 
GO:0005886plasma membraneIEA-
GO:0016323basolateral plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CNTFHCNTFciliary neurotrophic factor-HPRD,BioGRID1281789 
IL6BSF2 | HGF | HSF | IFNB2 | IL-6interleukin 6 (interferon, beta 2)-HPRD,BioGRID14557255 
IL6 interacts with IL6R (IL-6R-alpha)BIND15895091 
IL6STCD130 | CDw130 | GP130 | GP130-RAPS | IL6R-betainterleukin 6 signal transducer (gp130, oncostatin M receptor)-HPRD,BioGRID2788034 
MAGI1AIP3 | BAIAP1 | BAP1 | MAGI-1 | TNRC19 | WWP3membrane associated guanylate kinase, WW and PDZ domain containing 1-HPRD9169421 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD10462375 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID10982829 
WWP1AIP5 | DKFZp434D2111 | Tiul1 | hSDRP1WW domain containing E3 ubiquitin protein ligase 1-HPRD9169421 
WWP2AIP2 | WWp2-likeWW domain containing E3 ubiquitin protein ligase 2-HPRD9169421 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
BIOCARTA_IL6_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_HER2_PATHWAY 2217All SZGR genes in this pathway
ST_STAT3_PATHWAY 1110All SZGR genes in this pathway
SA_MMP_CYTOKINE_CONNECTION 159All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_IL6_7_PATHWAY 4740All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL_6_SIGNALING 119All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
LIU_SOX4_TARGETS_UP 13794All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_DN 4129All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN 187115All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP 238144All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_DN 13797All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP 197135All SZGR genes in this pathway
DUNNE_TARGETS_OF_AML1_MTG8_FUSION_UP 5232All SZGR genes in this pathway
MATTIOLI_MULTIPLE_MYELOMA_WITH_14Q32_TRANSLOCATIONS 3625All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_UP 7851All SZGR genes in this pathway
TENEDINI_MEGAKARYOCYTE_MARKERS 6648All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_AND_CD2_DN 5132All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_DN 3929All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN 6341All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
KRASNOSELSKAYA_ILF3_TARGETS_DN 4638All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
HOWLIN_CITED1_TARGETS_1_UP 3525All SZGR genes in this pathway
KONDO_EZH2_TARGETS 245148All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_UP 185112All SZGR genes in this pathway
LEE_EARLY_T_LYMPHOCYTE_DN 5736All SZGR genes in this pathway
LEE_NAIVE_T_LYMPHOCYTE 1910All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS 4430All SZGR genes in this pathway
LOPEZ_MESOTHELIOMA_SURVIVAL_OVERALL_UP 75All SZGR genes in this pathway
LOPEZ_MESOTHELIOMA_SURVIVAL_UP 119All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
DUAN_PRDM5_TARGETS 7952All SZGR genes in this pathway
GOBERT_CORE_OLIGODENDROCYTE_DIFFERENTIATION 4028All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2 9867All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-208155015561Ahsa-miR-208AUAAGACGAGCAAAAAGCUUGU
miR-236806871A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-3236806861Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-499155015561Ahsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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