Gene Page: IL12A

Summary
GeneID  3592
Symbol  IL12A
Synonyms  CLMF|IL-12A|NFSK|NKSF1|P35
Description  interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
See related  HGNC:5969|MIM:161560|Ensembl:ENSG00000168811|HPRD:01193|
Locus tag  -
Gene type  protein-coding
Map location  3q25.33-q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TESC0.780.65
AC005512.10.700.57
TPD52L10.690.54
HPCA0.690.57
C20orf1030.680.60
PDE1B0.670.67
LRPAP10.670.57
TMEM90A0.660.30
PPP1R1B0.660.18
GSTO20.650.51
Top 10 negatively co-expressed genes
SH2B2-0.29-0.50
FADS2-0.29-0.40
KIAA1949-0.29-0.41
TUBB2B-0.28-0.46
TUBB-0.28-0.26
TUBB3-0.28-0.26
MARCKSL1-0.28-0.34
KIAA1211-0.28-0.29
SH3BP2-0.28-0.45
ZNF311-0.28-0.32
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005125cytokine activityIDA1674604 
GO:0005125cytokine activityIEA-
GO:0005125cytokine activityTAS1673147 
GO:0005143interleukin-12 receptor bindingNAS1674604 
GO:0005515protein bindingIPI10899108 
GO:0042163interleukin-12 beta subunit bindingIEA-
GO:0046982protein heterodimerization activityIPI1674604 
GO:0045513interleukin-27 bindingIPI9342359 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetIDA7903063 
GO:0001916positive regulation of T cell mediated cytotoxicityIDA1674604 |2204066 
GO:0007050cell cycle arrestIDA16942485 
GO:0010224response to UV-BIDA8992506 
GO:0006955immune responseTAS9789052 
GO:0032816positive regulation of natural killer cell activationIDA1674604 
GO:0016477cell migrationIDA7903063 
GO:0042102positive regulation of T cell proliferationIEA-
GO:0032729positive regulation of interferon-gamma productionIDA1674604 
GO:0032496response to lipopolysaccharideIDA7605994 |8557999 
GO:0034393positive regulation of smooth muscle cell apoptosisIDA16942485 
GO:0042520positive regulation of tyrosine phosphorylation of Stat4 proteinIDA12372421 
GO:0045785positive regulation of cell adhesionIDA7903063 
GO:0050830defense response to Gram-positive bacteriumIEP1357073 
GO:0048662negative regulation of smooth muscle cell proliferationIDA16942485 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0043514interleukin-12 complexIDA2204066 
GO:0043514interleukin-12 complexIEA-
GO:0043514interleukin-12 complexNAS1674604 |14718574 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EBI3IL27BEpstein-Barr virus induced 3-HPRD934235 
IL12ACLMF | IL-12A | NFSK | NKSF1 | P35interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)p35 interacts with p35 to form a homodimer.BIND7527811 
IL12BCLMF | CLMF2 | IL-12B | NKSF | NKSF2interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)-HPRD,BioGRID10899108 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 10288All SZGR genes in this pathway
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 7151All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
KEGG_TYPE_I_DIABETES_MELLITUS 4438All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_ALLOGRAFT_REJECTION 3834All SZGR genes in this pathway
BIOCARTA_CYTOKINE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_INFLAM_PATHWAY 2924All SZGR genes in this pathway
BIOCARTA_DC_PATHWAY 2220All SZGR genes in this pathway
BIOCARTA_IL12_PATHWAY 2317All SZGR genes in this pathway
BIOCARTA_NO2IL12_PATHWAY 1714All SZGR genes in this pathway
BIOCARTA_NKT_PATHWAY 2921All SZGR genes in this pathway
BIOCARTA_TH1TH2_PATHWAY 1914All SZGR genes in this pathway
PID_IL27_PATHWAY 2620All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS 2418All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP 380213All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP 10869All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP 292168All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_UP 8657All SZGR genes in this pathway
WANG_TARGETS_OF_MLL_CBP_FUSION_UP 4426All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP 178111All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP 6229All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
BUDHU_LIVER_CANCER_METASTASIS_DN 77All SZGR genes in this pathway
MIKKELSEN_IPS_HCP_WITH_H3_UNMETHYLATED 8050All SZGR genes in this pathway
SEIKE_LUNG_CANCER_POOR_SURVIVAL 118All SZGR genes in this pathway
GHANDHI_DIRECT_IRRADIATION_UP 11068All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-212562631A,m8hsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.