Gene Page

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACP1	HAAP \| MGC111030 \| MGC3499	acid phosphatase 1, soluble	-	HPRD	1304913
AHSG	A2HS \| AHS \| FETUA \| HSGA	alpha-2-HS-glycoprotein	-	HPRD,BioGRID	7906861
CAV1	CAV \| MSTP085 \| VIP21	caveolin 1, caveolae protein, 22kDa	-	HPRD,BioGRID	10598578
CSK	MGC117393	c-src tyrosine kinase	CSK interacts with IR.	BIND	10026153
CSK	MGC117393	c-src tyrosine kinase	-	HPRD,BioGRID	10026153
DOK5	C20orf180 \| MGC16926	docking protein 5	-	HPRD	12730241
ENPP1	M6S1 \| NPP1 \| NPPS \| PC-1 \| PCA1 \| PDNP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	-	HPRD,BioGRID	10615944
FRS2	FRS2A \| FRS2alpha \| SNT \| SNT-1 \| SNT1	fibroblast growth factor receptor substrate 2	-	HPRD,BioGRID	10650943
GAB1	-	GRB2-associated binding protein 1	Two-hybrid	BioGRID	9658397
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	Grb10 interacts with IR.	BIND	9506989
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	-	HPRD,BioGRID	7479769 \|8621530
GRB14	-	growth factor receptor-bound protein 14	-	HPRD,BioGRID	9748281 \|11726652
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	Affinity Capture-Western	BioGRID	9083103
GRB7	-	growth factor receptor-bound protein 7	-	HPRD,BioGRID	10803466
HMGA1	HMG-R \| HMGA1A \| HMGIY \| MGC12816 \| MGC4242 \| MGC4854	high mobility group AT-hook 1	HMGA1 interacts with INSR locus.	BIND	15924147
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	-	HPRD,BioGRID	3109943
IGF2	C11orf43 \| FLJ22066 \| FLJ44734 \| INSIGF \| pp9974	insulin-like growth factor 2 (somatomedin A)	-	HPRD,BioGRID	9722981
INPPL1	SHIP2	inositol polyphosphate phosphatase-like 1	Affinity Capture-Western	BioGRID	12504111
INS	ILPR \| IRDN	insulin	-	HPRD	2550426
INSRR	IRR	insulin receptor-related receptor	-	HPRD,BioGRID	8916919
IRS1	HIRS-1	insulin receptor substrate 1	IRS-1 interacts with IR. This interaction was modeled on a demonstrated interaction between rat IRS-1 and human IR.	BIND	10026153
			Insulin Receptor Substrate-1 Binds to the Insulin Receptor. This interaction is modeled on demonstrated interaction between human IR and rat IRS-1	BIND	8626379
			-	HPRD,BioGRID	11606564
IRS2	-	insulin receptor substrate 2	-	HPRD,BioGRID	8626379
IRS2	-	insulin receptor substrate 2	Insulin Receptor Substrate-2 Binds to the Insulin Receptor. This interaction is modeled on demonstrated interaction between human IR and murine IRS-2.	BIND	8626379
JAK1	JAK1A \| JAK1B \| JTK3	Janus kinase 1 (a protein tyrosine kinase)	Phosphorylated IR-beta interacts with JAK-1.	BIND	9492017
KHDRBS1	FLJ34027 \| Sam68 \| p62	KH domain containing, RNA binding, signal transduction associated 1	Affinity Capture-Western	BioGRID	11604231
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	Affinity Capture-Western	BioGRID	11409918
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	-	HPRD,BioGRID	11409918
NAMPT	1110035O14Rik \| DKFZp666B131 \| MGC117256 \| PBEF \| PBEF1 \| VF \| VISFATIN	nicotinamide phosphoribosyltransferase	PBEF interacts with IR.	BIND	15604363
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	INSR (IR) interacts with PIK3R1. This interaction was modeled on a demonstrated interaction between INSR and PIK3R1 from unspecified species.	BIND	15735664
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	The insulin receptor (IR) interacts with p85-alpha.	BIND	8603569
PIK3R3	DKFZp686P05226 \| FLJ41892 \| p55 \| p55-GAMMA	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	-	HPRD,BioGRID	9524259
PRKCD	MAY1 \| MGC49908 \| PKCD \| nPKC-delta	protein kinase C, delta	-	HPRD,BioGRID	11266508
PTPN1	PTP1B	protein tyrosine phosphatase, non-receptor type 1	-	HPRD,BioGRID	8826975
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD,BioGRID	7493946 \|8135823
PTPN12	PTP-PEST \| PTPG1	protein tyrosine phosphatase, non-receptor type 12	-	HPRD,BioGRID	8454633
PTPN6	HCP \| HCPH \| HPTP1C \| PTP-1C \| SH-PTP1 \| SHP-1 \| SHP-1L \| SHP1	protein tyrosine phosphatase, non-receptor type 6	-	HPRD,BioGRID	7512963
PTPRF	FLJ43335 \| FLJ45062 \| FLJ45567 \| LAR	protein tyrosine phosphatase, receptor type, F	-	HPRD,BioGRID	1321126
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD	11409918
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD,BioGRID	1331107
SH2B1	DKFZp547G1110 \| FLJ30542 \| KIAA1299 \| SH2-B \| SH2B	SH2B adaptor protein 1	-	HPRD,BioGRID	9742218 \|10594240
SH2B2	APS	SH2B adaptor protein 2	-	HPRD	10196204
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	-	HPRD	9083103
SHC1	FLJ26504 \| SHC \| SHCA		Tyrosine-phosphorylated IR interacts with Shc. This interaction was modeled on a demonstrated interaction between human IR and Shc from an unspecified species.	BIND	10340378
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD family member 2	-	HPRD,BioGRID	9092546
SNX1	HsT17379 \| MGC8664 \| SNX1A \| Vps5	sorting nexin 1	-	HPRD,BioGRID	9819414
SNX2	MGC5204 \| TRG-9	sorting nexin 2	-	HPRD,BioGRID	9819414
SNX4	-	sorting nexin 4	-	HPRD,BioGRID	9819414
SNX6	MGC3157 \| MSTP010 \| TFAF2	sorting nexin 6	-	HPRD,BioGRID	11279102
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	Suppressors of cytokine signaling-1 associates with and inhibits the insulin receptor.	BIND	11342531
SOCS3	ATOD4 \| CIS3 \| Cish3 \| MGC71791 \| SOCS-3 \| SSI-3 \| SSI3	suppressor of cytokine signaling 3	-	HPRD,BioGRID	11071852 \|12560330
SOCS6	CIS4 \| HSPC060 \| SOCS4 \| SSI4 \| STAI4 \| STATI4	suppressor of cytokine signaling 6	Suppressors of cytokine signaling-6 associates with and inhibits the insulin receptor. This interaction is modeled on demonstrated interaction between human IR and murine SOCS-6.	BIND	11342531
SORBS1	CAP \| DKFZp451C066 \| DKFZp586P1422 \| FLAF2 \| FLJ12406 \| KIAA1296 \| R85FL \| SH3D5 \| SH3P12 \| SORB1	sorbin and SH3 domain containing 1	-	HPRD,BioGRID	11374898
SYNCRIP	GRY-RBP \| HNRPQ1 \| NSAP1 \| RP1-3J17.2 \| dJ3J17.2 \| hnRNP-Q \| pp68	synaptotagmin binding, cytoplasmic RNA interacting protein	-	HPRD,BioGRID	11994298
VAV1	VAV	vav 1 guanine nucleotide exchange factor	-	HPRD,BioGRID	7535775
VAV3	FLJ40431	vav 3 guanine nucleotide exchange factor	-	HPRD,BioGRID	11094073

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_ADHERENS_JUNCTION	75	53	All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY	137	103	All SZGR genes in this pathway
KEGG_TYPE_II_DIABETES_MELLITUS	47	41	All SZGR genes in this pathway
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION	42	29	All SZGR genes in this pathway
BIOCARTA_HDAC_PATHWAY	32	25	All SZGR genes in this pathway
BIOCARTA_GH_PATHWAY	28	22	All SZGR genes in this pathway
BIOCARTA_INSULIN_PATHWAY	22	16	All SZGR genes in this pathway
PID_INSULIN_PATHWAY	45	32	All SZGR genes in this pathway
PID_PTP1B_PATHWAY	52	40	All SZGR genes in this pathway
PID_TCPTP_PATHWAY	43	33	All SZGR genes in this pathway
PID_INSULIN_GLUCOSE_PATHWAY	26	24	All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_RECYCLING	23	9	All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE	87	64	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR	108	72	All SZGR genes in this pathway
REACTOME_SIGNAL_ATTENUATION	14	8	All SZGR genes in this pathway
REACTOME_PI3K_CASCADE	71	51	All SZGR genes in this pathway
REACTOME_SHC_RELATED_EVENTS	17	13	All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN	634	384	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_DN	116	79	All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN	352	225	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP	380	236	All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN	508	354	All SZGR genes in this pathway
WANG_BARRETTS_ESOPHAGUS_AND_ESOPHAGUS_CANCER_UP	26	12	All SZGR genes in this pathway
PEREZ_TP53_TARGETS	1174	695	All SZGR genes in this pathway
PEREZ_TP63_TARGETS	355	243	All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS	205	145	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN	712	443	All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN	203	134	All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_DN	103	59	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	811	508	All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX	230	156	All SZGR genes in this pathway
BENPORATH_CYCLING_GENES	648	385	All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC	182	116	All SZGR genes in this pathway
MANALO_HYPOXIA_UP	207	145	All SZGR genes in this pathway
URS_ADIPOCYTE_DIFFERENTIATION_UP	74	51	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP	103	69	All SZGR genes in this pathway
LU_AGING_BRAIN_UP	262	186	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR	681	420	All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE	246	153	All SZGR genes in this pathway
HILLION_HMGA1_TARGETS	90	71	All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN	353	226	All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_MARKERS	19	16	All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN	108	68	All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_UP	185	112	All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED	351	238	All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3	266	180	All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN	225	124	All SZGR genes in this pathway
DANG_BOUND_BY_MYC	1103	714	All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G1_S	147	76	All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP	504	321	All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP	344	215	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D	658	397	All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2	98	67	All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP	279	155	All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY	1839	928	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	2393	2400	1A,m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-128	194	200	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	194	200	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-15/16/195/424/497	577	583	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-379	2391	2397	m8	hsa-miR-379^brain	UGGUAGACUAUGGAACGUA
miR-496	2323	2330	1A,m8	hsa-miR-496	AUUACAUGGCCAAUCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.