Gene Page: IRS1

Summary
GeneID  3667
Symbol  IRS1
Synonyms  HIRS-1
Description  insulin receptor substrate 1
See related  HGNC:6125|MIM:147545|Ensembl:ENSG00000169047|HPRD:00943|
Locus tag  -
Gene type  protein-coding
Map location  2q36
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0631 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RUVBL20.940.95
C17orf490.930.94
PSMB70.930.94
PRMT10.930.95
PSMA70.930.94
TRIM390.930.92
CLPP0.930.92
ERGIC30.930.95
RRP90.930.93
DDX490.930.93
Top 10 negatively co-expressed genes
AF347015.27-0.72-0.82
AF347015.33-0.72-0.82
AF347015.8-0.71-0.81
MT-CO2-0.70-0.78
MT-CYB-0.70-0.81
AF347015.15-0.70-0.82
AF347015.26-0.69-0.84
AF347015.31-0.69-0.77
AF347015.2-0.69-0.81
AF347015.9-0.65-0.78
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS1311924 |8513971 
GO:0005159insulin-like growth factor receptor bindingIPI7541045 
GO:0005158insulin receptor bindingIPI7537849 |7559478 
GO:0005069transmembrane receptor protein tyrosine kinase docking protein activityTAS1648180 
GO:0005515protein bindingIPI8388384 |9295312 |11018022 
GO:0042169SH2 domain bindingISS-
GO:0019901protein kinase bindingIEA-
GO:0043548phosphoinositide 3-kinase bindingIPI16043515 
GO:0043548phosphoinositide 3-kinase bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS1311924 
GO:0008286insulin receptor signaling pathwayIPI7537849 |7559478 
GO:0048009insulin-like growth factor receptor signaling pathwayIPI7541045 
GO:0043491protein kinase B signaling cascadeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeISS-
GO:0005634nucleusISS-
GO:0005737cytoplasmISS-
GO:0005901caveolaIDA15182363 
GO:0005886plasma membraneEXP12167717 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1-HPRD,BioGRID10497255 
ALKCD246 | Ki-1 | TFG/ALKanaplastic lymphoma receptor tyrosine kinase-HPRD9174053 
AP3S1CLAPS3 | Sigma3Aadaptor-related protein complex 3, sigma 1 subunit-HPRD,BioGRID9792713 
ATP2A1ATP2A | SERCA1ATPase, Ca++ transporting, cardiac muscle, fast twitch 1-HPRD9295312 
BCL2Bcl-2B-cell CLL/lymphoma 2Affinity Capture-WesternBioGRID10679027 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1-HPRD,BioGRID10679027 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)-HPRD11035789 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinase-HPRD,BioGRID12351658 
FRAP1FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1FK506 binding protein 12-rapamycin associated protein 1Affinity Capture-WesternBioGRID11287630 
GRB10GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSSgrowth factor receptor-bound protein 10Reconstituted ComplexBioGRID8621530 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD7488107 
Affinity Capture-Western
Reconstituted Complex
BioGRID8491186 |8536716 
|12173038 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptorIGFIR interacts with IRS-1.BIND7541045 
IRS-1 interacts with IGF-IR. This interaction was modeled on a demonstrated interaction between rat IRS-1 and human IGF-IR.BIND10026153 
-HPRD,BioGRID7559507 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaAffinity Capture-WesternBioGRID12351658 
IKBKGAMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMOinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma-HPRD12351658 
IL4RCD124 | IL4RAinterleukin 4 receptor-HPRD,BioGRID8599766 
INSRCD220 | HHF5insulin receptorIRS-1 interacts with IR. This interaction was modeled on a demonstrated interaction between rat IRS-1 and human IR.BIND10026153 
Insulin Receptor Substrate-1 Binds to the Insulin Receptor. This interaction is modeled on demonstrated interaction between human IR and rat IRS-1BIND8626379 
-HPRD,BioGRID11606564 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)Affinity Capture-Western
Biochemical Activity
BioGRID7499365 |9492017 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)Affinity Capture-Western
Biochemical Activity
BioGRID9492017 |11208867 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)-HPRD,BioGRID7499365 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1Affinity Capture-WesternBioGRID11604231 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8-HPRD,BioGRID10722755 |11606564 
|12417588 
MAPK9JNK-55 | JNK2 | JNK2A | JNK2ALPHA | JNK2B | JNK2BETA | PRKM9 | SAPK | p54a | p54aSAPKmitogen-activated protein kinase 9-HPRD12417588 
NISCHFLJ14425 | FLJ40413 | FLJ90519 | I-1 | IRAS | KIAA0975nischarinAffinity Capture-WesternBioGRID11912194 
PHIPFLJ20705 | FLJ45918 | MGC90216 | WDR11 | ndrppleckstrin homology domain interacting protein-HPRD11018022 
PIK3CAMGC142161 | MGC142163 | PI3K | p110-alphaphosphoinositide-3-kinase, catalytic, alpha polypeptideAffinity Capture-WesternBioGRID16354680 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Affinity Capture-Western
Far Western
BioGRID1381348 |12107746 
|12173038 |12730242 
-HPRD1381348 |12173038 
-HPRD12220227 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)IRS-1 interacts with p85-beta. This interaction was modeled based on a demonstrated interaction between IRS-1 from an unspecified species and p85-beta from an unknown species.BIND11172806 
-HPRD11120660 
PIK3R3DKFZp686P05226 | FLJ41892 | p55 | p55-GAMMAphosphoinositide-3-kinase, regulatory subunit 3 (gamma)-HPRD,BioGRID7542745 |9415396 
|10417350 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, delta-HPRD,BioGRID12031982 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD,BioGRID9822703 
PTPN1PTP1Bprotein tyrosine phosphatase, non-receptor type 1-HPRD,BioGRID10660596 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD,BioGRID8505282 |9756938 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, C-HPRD,BioGRID8557683 
PTPRFFLJ43335 | FLJ45062 | FLJ45567 | LARprotein tyrosine phosphatase, receptor type, F-HPRD10660596 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Direct interaction between IRS-1 and SHC. This interaction was modeled on a demonstrated interaction between rat IRS-1 and human SHCBIND9202037 
-HPRD,BioGRID7499194 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1-HPRD,BioGRID11208867 |12228220 
SOCS3ATOD4 | CIS3 | Cish3 | MGC71791 | SOCS-3 | SSI-3 | SSI3suppressor of cytokine signaling 3-HPRD12228220 
TUBrd5tubby homolog (mouse)-HPRD10455176 
TYK2JTK1tyrosine kinase 2-HPRD,BioGRID8550573 
UBTFNOR-90 | UBFupstream binding transcription factor, RNA polymerase I-HPRD,BioGRID12554758 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide-HPRD,BioGRID9422753 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideIRS-1 interacts with 14-3-3-epsilon isoform. This interaction was modeled on a demonstrated interaction between human IRS-1 and mouse 14-3-3-epsilon isoform.BIND9111084 
-HPRD,BioGRID9111084 |9312143 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptideAffinity Capture-WesternBioGRID11969417 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD,BioGRID9312143 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
KEGG_TYPE_II_DIABETES_MELLITUS 4741All SZGR genes in this pathway
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 4229All SZGR genes in this pathway
BIOCARTA_GH_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_IGF1_PATHWAY 2116All SZGR genes in this pathway
BIOCARTA_IL4_PATHWAY 118All SZGR genes in this pathway
BIOCARTA_IL2RB_PATHWAY 3826All SZGR genes in this pathway
BIOCARTA_INSULIN_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_IGF1R_PATHWAY 2320All SZGR genes in this pathway
BIOCARTA_EIF4_PATHWAY 2419All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 2723All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 5141All SZGR genes in this pathway
PID_INSULIN_PATHWAY 4532All SZGR genes in this pathway
PID_IL4_2PATHWAY 6543All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_RET_PATHWAY 3929All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_IL2_1PATHWAY 5543All SZGR genes in this pathway
PID_IGF1_PATHWAY 3023All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
PID_S1P_S1P2_PATHWAY 2419All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING 2419All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_PI3K_AKT_ACTIVATION 3829All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_SIGNAL_ATTENUATION 148All SZGR genes in this pathway
REACTOME_SOS_MEDIATED_SIGNALLING 1413All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_PI3K_CASCADE 7151All SZGR genes in this pathway
SAMOLS_TARGETS_OF_KHSV_MIRNAS_DN 6235All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER 2219All SZGR genes in this pathway
SCHEIDEREIT_IKK_TARGETS 1815All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS 5845All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
LEE_TARGETS_OF_PTCH1_AND_SUFU_UP 5337All SZGR genes in this pathway
BASSO_CD40_SIGNALING_DN 6844All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN 5032All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_10HR_DN 5637All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
DASU_IL6_SIGNALING_SCAR_UP 3021All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_DN 178121All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_WITHOUT_MGMT_48HR_DN 3225All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G6 153112All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D8 4029All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
MASSARWEH_RESPONSE_TO_ESTRADIOL 6147All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
JIANG_TIP30_TARGETS_UP 4628All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_UP 16799All SZGR genes in this pathway
DING_LUNG_CANCER_BY_MUTATION_RATE 2018All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
WINZEN_DEGRADED_VIA_KHSRP 10070All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP 11687All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
ZHANG_ADIPOGENESIS_BY_BMP7 1412All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-126/126-3p1311371Ahsa-miR-126brainUCGUACCGUGAGUAAUAAUGC
miR-1282322391A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-145410m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-1836716781A,m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-200bc/4294494551Ahsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-27233239m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-5p154160m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-487b132138m8hsa-miR-487bAAUCGUACAGGGUCAUCCACUU
miR-96209215m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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