Gene Page: LEP

Summary
GeneID  3952
Symbol  LEP
Synonyms  FLJ94114|OB|OBS
Description  leptin
See related  HGNC:6553|MIM:164160|Ensembl:ENSG00000174697|HPRD:01249|
Locus tag  -
Gene type  protein-coding
Map location  7q31.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PTAR10.880.90
ARHGAP50.860.87
ITGAV0.860.89
PIK3C2A0.840.88
ITGB80.840.89
DPY19L40.820.84
QKI0.810.84
ATL30.810.84
MKLN10.790.82
AP3B10.790.75
Top 10 negatively co-expressed genes
RP9P-0.33-0.48
NANOS3-0.33-0.38
AL022328.1-0.33-0.41
HES4-0.33-0.40
IL32-0.32-0.42
SNHG12-0.32-0.44
C9orf142-0.32-0.33
ST20-0.32-0.40
AC016757.1-0.30-0.34
C16orf79-0.29-0.33
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIEA-
GO:0005515protein bindingIEA-
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008206bile acid metabolic processIEA-
GO:0006112energy reserve metabolic processTAS9537324 
GO:0006006glucose metabolic processIEA-
GO:0007165signal transductionIEA-
GO:0008203cholesterol metabolic processIEA-
GO:0008343adult feeding behaviorISS-
GO:0006629lipid metabolic processIEA-
GO:0042755eating behaviorIEA-
GO:0019222regulation of metabolic processIEA-
GO:0032099negative regulation of appetiteISS-
GO:0030300regulation of cholesterol absorptionIEA-
GO:0045639positive regulation of myeloid cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
A2MCPAMD5 | DKFZp779B086 | FWP007 | S863-7alpha-2-macroglobulin-HPRD,BioGRID9724081 
CLUAAG4 | APOJ | CLI | KUB1 | MGC24903 | SGP-2 | SGP2 | SP-40 | TRPM-2 | TRPM2clusterin-HPRD,BioGRID12824284 
GHRLMTLRP | obestatinghrelin/obestatin prepropeptide-HPRD11196643 
HK3HKIII | HXK3hexokinase 3 (white cell)HKIII interacts with leptin. This interaction was modeled on a demonstrated interaction between rat HKIII and human leptin.BIND11068878 
-HPRD,BioGRID11068878 
LEPRCD295 | OBRleptin receptor-HPRD8608603 
PRKAA2AMPK | AMPK2 | PRKAAprotein kinase, AMP-activated, alpha 2 catalytic subunit-HPRD11797013 
SIGLEC6CD327 | CD33L | CD33L1 | CDw327 | OBBP1 | SIGLEC-6sialic acid binding Ig-like lectin 6-HPRD10428856 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)Reconstituted ComplexBioGRID12824284 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 272195All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
BIOCARTA_LEPTIN_PATHWAY 1111All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_HIF1_TFPATHWAY 6652All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN 1611All SZGR genes in this pathway
REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION 2214All SZGR genes in this pathway
REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 1912All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 7253All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
NADLER_OBESITY_UP 6134All SZGR genes in this pathway
AFFAR_YY1_TARGETS_DN 234137All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_A_UP 8452All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
MATZUK_CENTRAL_FOR_FEMALE_FERTILITY 2925All SZGR genes in this pathway
CADWELL_ATG16L1_TARGETS_UP 9356All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
MEISSNER_NPC_ICP_WITH_H3_UNMETHYLATED 2415All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K27ME3 4227All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-29165216591A,m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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