Gene Page: LPL

Summary
GeneID  4023
Symbol  LPL
Synonyms  HDLCQ11|LIPD
Description  lipoprotein lipase
See related  HGNC:6677|MIM:609708|Ensembl:ENSG00000175445|HPRD:01999|
Locus tag  -
Gene type  protein-coding
Map location  8p22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
ExpressionExpressionP value: 1.479 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DDX470.870.88
GNPAT0.860.89
ZW100.860.84
DHX400.860.86
CLNS1A0.850.81
NUP350.840.84
BPGM0.840.85
VPS450.840.89
USP390.840.87
STT3A0.840.84
Top 10 negatively co-expressed genes
MT-CO2-0.72-0.77
AF347015.8-0.71-0.78
AF347015.33-0.70-0.77
AF347015.27-0.70-0.76
AF347015.15-0.68-0.77
AF347015.2-0.68-0.78
MT-CYB-0.68-0.75
AF347015.26-0.68-0.78
AF347015.31-0.67-0.74
AF347015.21-0.65-0.73
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIPINeurotransmitter (GO term level: 4)10085125 
GO:0004620phospholipase activityISS10727238 
GO:0005319lipid transporter activityIEA-
GO:0004806triacylglycerol lipase activityISS10727238 
GO:0004465lipoprotein lipase activityIEA-
GO:0016787hydrolase activityIEA-
GO:0008201heparin bindingTAS1969408 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016042lipid catabolic processIEA-
GO:0008015blood circulationTAS1969408 
GO:0006644phospholipid metabolic processISS10727238 
GO:0006641triacylglycerol metabolic processISS10727238 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionTAS1969408 
GO:0005886plasma membraneIEA-
GO:0031225anchored to membraneIEA-
GO:0042627chylomicronIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APOC2MGC75082apolipoprotein C-II-HPRD10727238 |11579204 
ASCC2ASC1p100activating signal cointegrator 1 complex subunit 2Two-hybridBioGRID16169070 
CETPHDLCQ10cholesteryl ester transfer protein, plasma-HPRD9374130 
COPS6CSN6 | MOV34-34KDCOP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)Two-hybridBioGRID16169070 
EMDEDMD | LEMD5 | STAemerinTwo-hybridBioGRID12755701 
KIAA1377-KIAA1377Two-hybridBioGRID16169070 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD1281473|7510694 |7989348 
Reconstituted ComplexBioGRID1281473 |7510694 
|7989348 
LRP2DBS | gp330low density lipoprotein-related protein 2-HPRD,BioGRID7686151 
LUC7L2CGI-59 | CGI-74 | FLJ10657 | LUC7B2LUC7-like 2 (S. cerevisiae)Two-hybridBioGRID16169070 
PTPN4PTPMEG | PTPMEG1protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)Two-hybridBioGRID16169070 
RPL18A-ribosomal protein L18aTwo-hybridBioGRID16169070 
UBE2ZFLJ13855 | HOYS7 | USE1ubiquitin-conjugating enzyme E2ZTwo-hybridBioGRID16169070 
VLDLRCHRMQ1 | FLJ35024 | VLDLRCHvery low density lipoprotein receptor-HPRD,BioGRID7592875 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_GLYCEROLIPID_METABOLISM 4926All SZGR genes in this pathway
KEGG_PPAR_SIGNALING_PATHWAY 6947All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
BIOCARTA_PPARA_PATHWAY 5843All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 7253All SZGR genes in this pathway
REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 4637All SZGR genes in this pathway
REACTOME_LIPOPROTEIN_METABOLISM 2824All SZGR genes in this pathway
REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT 1615All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_DN 11679All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP 175120All SZGR genes in this pathway
BILBAN_B_CLL_LPL_UP 6339All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP 157104All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_UP 14175All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_DN 14295All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_DN 3324All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
OLSSON_E2F3_TARGETS_DN 4933All SZGR genes in this pathway
WEINMANN_ADAPTATION_TO_HYPOXIA_UP 2924All SZGR genes in this pathway
WEINMANN_ADAPTATION_TO_HYPOXIA_DN 4133All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
BORLAK_LIVER_CANCER_EGF_UP 5741All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1 229137All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 153102All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
PETRETTO_CARDIAC_HYPERTROPHY 3426All SZGR genes in this pathway
LE_EGR2_TARGETS_DN 10884All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_UP 5430All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_TGFA_UP 6140All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_UP 6440All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_UP 5634All SZGR genes in this pathway
LEE_LIVER_CANCER_CIPROFIBRATE_UP 6042All SZGR genes in this pathway
LEE_LIVER_CANCER_DENA_UP 6040All SZGR genes in this pathway
LEE_LIVER_CANCER_E2F1_UP 6235All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_MUTATED_VH_GENES 1814All SZGR genes in this pathway
GUO_HEX_TARGETS_DN 6536All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN 7748All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_UP 11484All SZGR genes in this pathway
GERY_CEBP_TARGETS 12690All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
URS_ADIPOCYTE_DIFFERENTIATION_UP 7451All SZGR genes in this pathway
BURTON_ADIPOGENESIS_10 3017All SZGR genes in this pathway
RUAN_RESPONSE_TO_TNF_TROGLITAZONE_DN 4224All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
MODY_HIPPOCAMPUS_NEONATAL 3525All SZGR genes in this pathway
RUAN_RESPONSE_TO_TNF_DN 8450All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_0HR 6348All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
WENG_POR_TARGETS_LIVER_UP 4129All SZGR genes in this pathway
BURTON_ADIPOGENESIS_6 189112All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
STEARMAN_TUMOR_FIELD_EFFECT_UP 3622All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN 6139All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
LIN_NPAS4_TARGETS_UP 163100All SZGR genes in this pathway
CADWELL_ATG16L1_TARGETS_UP 9356All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 13179All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN 7447All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_DN 8051All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6 7548All SZGR genes in this pathway
ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_UP 8451All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
CHANGOLKAR_H2AFY_TARGETS_UP 4828All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_UP 13596All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_36HR 15288All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_WITH_H4K20ME1_MARK 14582All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
GUILLAUMOND_KLF10_TARGETS_UP 5139All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_UP 266142All SZGR genes in this pathway
ROESSLER_LIVER_CANCER_METASTASIS_UP 10772All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN 9974All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-29179618031A,m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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