Gene Page: LRP1

Summary
GeneID  4035
Symbol  LRP1
Synonyms  A2MR|APOER|APR|CD91|FLJ16451|IGFBP3R|LRP|MGC88725|TGFBR5
Description  low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
See related  HGNC:6692|MIM:107770|Ensembl:ENSG00000123384|HPRD:00138|
Locus tag  -
Gene type  protein-coding
Map location  12q13-q14
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.7051 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
COL3A10.900.64
OLFML30.870.73
C70.860.73
BMP50.860.59
ASPN0.850.74
OGN0.820.78
PCOLCE0.810.48
AL137026.30.810.54
SERPIND10.800.59
COL1A20.800.67
Top 10 negatively co-expressed genes
AF347015.33-0.25-0.19
ACADVL-0.24-0.27
AF347015.26-0.24-0.19
S100A1-0.24-0.12
AF347015.8-0.24-0.19
MT-CO2-0.24-0.18
AF347015.2-0.24-0.20
AF347015.27-0.24-0.17
AF347015.15-0.23-0.17
AC018755.7-0.23-0.15
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityTAS10880251 
GO:0005509calcium ion bindingIEA-
GO:0005509calcium ion bindingTAS3266596 
GO:0005319lipid transporter activityTAS3266596 
GO:0008034lipoprotein bindingTAS2779654 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008283cell proliferationTAS3266596 
GO:0006629lipid metabolic processTAS3266596 
GO:0006897endocytosisIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030178negative regulation of Wnt receptor signaling pathwayIEA-
GO:0043277apoptotic cell clearanceIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionTAS2779654 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0005905coated pitIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS3266596 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
A2MCPAMD5 | DKFZp779B086 | FWP007 | S863-7alpha-2-macroglobulin-HPRD,BioGRID10652313 
ANAPC10APC10 | DKFZp564L0562 | DOC1anaphase promoting complex subunit 10-HPRD,BioGRID10827173 
APBA2D15S1518E | HsT16821 | LIN-10 | MGC99508 | MGC:14091 | MINT2 | X11Lamyloid beta (A4) precursor protein-binding, family A, member 2Two-hybridBioGRID10827173 
APBB1FE65 | MGC:9072 | RIRamyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)-HPRD,BioGRID9837937 
APOEAD2 | LPG | MGC1571 | apoproteinapolipoprotein E-HPRD11421580 
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor protein-HPRD7543026 |12212791 
C3ARMD9 | ASP | CPAMD1complement component 3-HPRD10608878 
C4BPAC4BP | PRPcomplement component 4 binding protein, alpha-HPRD11705989 
CALCRCRT | CTR | CTR1calcitonin receptorAffinity Capture-Western
Reconstituted Complex		BioGRID12821648 
CALRCRT | FLJ26680 | RO | SSA | cC1qRcalreticulin-HPRD,BioGRID12821648 |14980518 
CANXCNX | FLJ26570 | IP90 | P90calnexin-HPRD,BioGRID14980518 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 molecule-HPRD9804823 
CTGFCCN2 | HCS24 | IGFBP8 | MGC102839 | NOV2connective tissue growth factor-HPRD14585398 
CTSGCG | MGC23078cathepsin GLRP interacts with Cathepsin G.BIND15131125 
DAB1-disabled homolog 1 (Drosophila)-HPRD,BioGRID10827173 
DAB2DOC-2 | DOC2 | FLJ26626disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)Reconstituted ComplexBioGRID11247302 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID10827173 
ELA2GE | HLE | HNE | NE | PMN-Eelastase 2, neutrophilLRP interacts with Elastase 2.BIND15131125 
F8AHF | DXS1253E | F8B | F8C | FVIII | HEMAcoagulation factor VIII, procoagulant component-HPRD,BioGRID12522143 
F9FIX | HEMB | MGC129641 | MGC129642 | PTCcoagulation factor IX-HPRD,BioGRID12522212 
FURINFUR | PACE | PCSK3 | SPC1furin (paired basic amino acid cleaving enzyme)-HPRD8546712 
GIPC1C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2GIPC PDZ domain containing family, member 1Reconstituted Complex
Two-hybrid		BioGRID10827173 
GTPBP1GP-1 | GP1 | HSPC018 | MGC20069GTP binding protein 1-HPRD9820815 
GULP1CED-6 | CED6 | FLJ31156 | GULPGULP, engulfment adaptor PTB domain containing 1-HPRD,BioGRID11729193 
HSP90B1ECGP | GP96 | GRP94 | TRA1heat shock protein 90kDa beta (Grp94), member 1-HPRD11861214 
ITGB1BP1DKFZp686K08158 | ICAP-1A | ICAP-1B | ICAP-1alpha | ICAP1 | ICAP1A | ICAP1Bintegrin beta 1 binding protein 1-HPRD,BioGRID10827173 
KAT5ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2K(lysine) acetyltransferase 5-HPRD,BioGRID12888553 
LIPCHDLCQ12 | HL | HTGL | LIPHlipase, hepatic-HPRD,BioGRID7721852 
LPLHDLCQ11 | LIPDlipoprotein lipase-HPRD1281473|7510694 |7989348 
Reconstituted ComplexBioGRID1281473 |7510694 
|7989348 
LRPAP1A2MRAP | A2RAP | HBP44 | MGC138272 | MRAP | RAPlow density lipoprotein receptor-related protein associated protein 1-HPRD,BioGRID1374383 |1718973 
|10747918 
LTFGIG12 | HLF2 | LFlactotransferrin-HPRD1464627 
MAPK8IP1IB1 | JIP-1 | JIP1 | PRKM8IPmitogen-activated protein kinase 8 interacting protein 1-HPRD,BioGRID10827173 
MAPK8IP2IB2 | JIP2 | PRKM8IPLmitogen-activated protein kinase 8 interacting protein 2Reconstituted Complex
Two-hybrid		BioGRID10827173 
MDKFLJ27379 | MK | NEGF2midkine (neurite growth-promoting factor 2)-HPRD,BioGRID10772929 
MMP13CLG3matrix metallopeptidase 13 (collagenase 3)-HPRD10514495 
MMP14MMP-X1 | MT1-MMP | MTMMP1matrix metallopeptidase 14 (membrane-inserted)-HPRD,BioGRID14645246 
MMP15MT2-MMP | MTMMP2 | SMCP-2matrix metallopeptidase 15 (membrane-inserted)-HPRD14645246 
MMP16MMP-X2 | MT-MMP2 | MT-MMP3 | MT3-MMPmatrix metallopeptidase 16 (membrane-inserted)-HPRD14645246 
MMP17MT4-MMPmatrix metallopeptidase 17 (membrane-inserted)-HPRD14645246 
NOS1AP6330408P19Rik | CAPON | MGC138500nitric oxide synthase 1 (neuronal) adaptor protein-HPRD,BioGRID10827173 
PDGFBFLJ12858 | PDGF2 | SIS | SSV | c-sisplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)-HPRD,BioGRID11854294 
PDIA2PDA2 | PDI | PDIP | PDIRprotein disulfide isomerase family A, member 2Affinity Capture-WesternBioGRID14980518 
PLATDKFZp686I03148 | T-PA | TPAplasminogen activator, tissue-HPRD,BioGRID1502153 |10632583 
PLAURCD87 | UPAR | URKRplasminogen activator, urokinase receptor-HPRD,BioGRID11359936 
SCN3AKIAA1356 | NAC3 | Nav1.3sodium channel, voltage-gated, type III, alpha subunitTwo-hybridBioGRID10827173 
SERPINA1A1A | A1AT | AAT | MGC23330 | MGC9222 | PI | PI1 | PRO2275serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1LRP interacts with alpha-1-PI.BIND15131125 
SERPINA3AACT | ACT | GIG24 | GIG25 | MGC88254serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3LRP interacts with alpha-1-ACT.BIND15131125 
SERPINE1PAI | PAI-1 | PAI1 | PLANH1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1-HPRD,BioGRID15001579 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Affinity Capture-Western
Reconstituted Complex		BioGRID11854294 |12789267 
-HPRD12069755 |12789267 
SNX17KIAA0064sorting nexin 17Reconstituted ComplexBioGRID12169628 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Biochemical ActivityBioGRID11854294 
SYNJ2BPARIP2 | FLJ11271 | FLJ41973 | OMP25synaptojanin 2 binding protein-HPRD,BioGRID10827173 
THBS1THBS | TSP | TSP1thrombospondin 1-HPRD,BioGRID9045712 |14991768 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
ST_WNT_BETA_CATENIN_PATHWAY 3428All SZGR genes in this pathway
PID_AMB2_NEUTROPHILS_PATHWAY 4132All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY 4230All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
JOHANSSON_BRAIN_CANCER_EARLY_VS_LATE_DN 4535All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
NADLER_OBESITY_UP 6134All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_HEREDITARY_VS_SPORADIC 5032All SZGR genes in this pathway
CHANG_IMMORTALIZED_BY_HPV31_DN 6545All SZGR genes in this pathway
JIANG_VHL_TARGETS 13891All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C2 2518All SZGR genes in this pathway
VERRECCHIA_EARLY_RESPONSE_TO_TGFB1 5843All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_UP 9564All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
ABE_INNER_EAR 4826All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO_OR_UV 6344All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS 8056All SZGR genes in this pathway
MIZUKAMI_HYPOXIA_DN 65All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN 13899All SZGR genes in this pathway
SETLUR_PROSTATE_CANCER_TMPRSS2_ERG_FUSION_UP 6748All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/107213219m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-200bc/4291671741A,m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-2051181251A,m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-369-3p169175m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-4961101161Ahsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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