Gene Page: ARNTL

Summary
GeneID  406
Symbol  ARNTL
Synonyms  BMAL1|BMAL1c|JAP3|MGC47515|MOP3|PASD3|TIC|bHLHe5
Description  aryl hydrocarbon receptor nuclear translocator-like
See related  HGNC:701|MIM:602550|Ensembl:ENSG00000133794|HPRD:03973|
Locus tag  -
Gene type  protein-coding
Map location  11p15
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
STK250.880.83
PSMB20.850.82
DDX410.850.80
TCF250.850.78
RXRB0.850.82
MARS0.840.80
AGAP30.840.77
GDI10.840.81
CACNB30.840.79
FARSA0.830.75
Top 10 negatively co-expressed genes
MT-CO2-0.76-0.67
AF347015.26-0.75-0.69
MT-CYB-0.72-0.66
AF347015.31-0.72-0.67
AF347015.33-0.72-0.65
AF347015.2-0.72-0.64
AF347015.8-0.72-0.66
NOSTRIN-0.70-0.67
AF347015.21-0.69-0.67
AF347015.18-0.69-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityIEA-
GO:0003700transcription factor activityIEA-
GO:0017162aryl hydrocarbon receptor bindingIPI9079689 
GO:0051879Hsp90 protein bindingIDA9079689 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007165signal transductionIEA-
GO:0007623circadian rhythmTAS9616112 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIGI9576906 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005667transcription factor complexIPI9576906 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AHR-aryl hydrocarbon receptor-HPRD,BioGRID9079689 
BHLHB2DEC1 | SHARP-2 | STRA13 | Stra14 | bHLHe40basic helix-loop-helix domain containing, class B, 2-HPRD12397359 
CLOCKKAT13D | KIAA0334 | bHLHe8clock homolog (mouse)Two-hybridBioGRID11439184 |14701734 
-HPRD9989497 
CRY1PHLL1cryptochrome 1 (photolyase-like)-HPRD,BioGRID10531061 
CSNK1EHCKIE | MGC10398casein kinase 1, epsilon-HPRD,BioGRID11875063 
EP300KAT3B | p300E1A binding protein p300Reconstituted ComplexBioGRID14645221 
EPAS1ECYT4 | HIF2A | HLF | MOP2 | PASD2endothelial PAS domain protein 1-HPRD,BioGRID9576906 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)-HPRD,BioGRID9576906 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD,BioGRID9079689 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2BReconstituted ComplexBioGRID14645221 
NPAS2FLJ23138 | MGC71151 | MOP4 | PASD4 | bHLHe9neuronal PAS domain protein 2in vitro
in vivo
Two-hybrid		BioGRID9576906 |11439184 
NPAS4Le-PAS | NXF | PASD10neuronal PAS domain protein 4-HPRD,BioGRID14701734 
RARANR1B1 | RARretinoic acid receptor, alphaReconstituted ComplexBioGRID11439184 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alphaReconstituted ComplexBioGRID11439184 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CIRCADIAN_RHYTHM_MAMMAL 1313All SZGR genes in this pathway
PID_CIRCADIAN_PATHWAY 1615All SZGR genes in this pathway
REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION 3627All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 10472All SZGR genes in this pathway
REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION 2417All SZGR genes in this pathway
REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA 2316All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
REACTOME_CIRCADIAN_CLOCK 5340All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION 7751All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_6 8454All SZGR genes in this pathway
AMUNDSON_RESPONSE_TO_ARSENITE 217143All SZGR genes in this pathway
WIEMANN_TELOMERE_SHORTENING_AND_CHRONIC_LIVER_DAMAGE_UP 85All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1 229137All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
SHIPP_DLBCL_CURED_VS_FATAL_DN 4530All SZGR genes in this pathway
UEDA_CENTRAL_CLOCK 8862All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_CIS 12877All SZGR genes in this pathway
UEDA_PERIFERAL_CLOCK 169111All SZGR genes in this pathway
DORSAM_HOXA9_TARGETS_DN 3222All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_UP 7148All SZGR genes in this pathway
BILD_MYC_ONCOGENIC_SIGNATURE 206117All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_DN 314188All SZGR genes in this pathway
TUOMISTO_TUMOR_SUPPRESSION_BY_COL13A1_UP 189All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
MATZUK_STEROIDOGENESIS 76All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
CUI_GLUCOSE_DEPRIVATION 6044All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_CLASSICAL 162122All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_DN 14888All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-141/200a193199m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-142-3p3523591A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-1533173231Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-1552382441Ahsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-203.13293351Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-2765711Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-3812452511Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-4483163231A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-494490496m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-5052672741A,m8hsa-miR-505GUCAACACUUGCUGGUUUCCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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