Gene Page: ARRB2

Summary
GeneID  409
Symbol  ARRB2
Synonyms  ARB2|ARR2|BARR2|DKFZp686L0365
Description  arrestin, beta 2
See related  HGNC:712|MIM:107941|Ensembl:ENSG00000141480|HPRD:00147|
Locus tag  -
Gene type  protein-coding
Map location  17p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ADAM230.910.89
ATP2A20.910.91
AAK10.900.87
MAP7D20.900.87
KCNC20.880.74
PPM1H0.880.83
KCND30.880.87
ANKRD34C0.880.59
CDS10.880.85
PAQR90.870.84
Top 10 negatively co-expressed genes
RAB13-0.40-0.53
EFEMP2-0.40-0.41
RAB34-0.39-0.49
RPL35-0.38-0.43
BCL7C-0.38-0.44
GTF3C6-0.38-0.33
NME4-0.37-0.46
C1orf61-0.37-0.52
AC006276.2-0.37-0.35
RPL31-0.36-0.37
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI17353931 |17620599 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001932regulation of protein amino acid phosphorylationIEA-
GO:0007165signal transductionIEA-
GO:0007179transforming growth factor beta receptor signaling pathwayIDA12958365 
GO:0008277regulation of G-protein coupled receptor protein signaling pathwayIEA-
GO:0007600sensory perceptionIEA-
GO:0031623receptor internalizationIDA12958365 
GO:0050896response to stimulusIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneTAS9346876 
GO:0031410cytoplasmic vesicleIDA12958365 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AGTR1AG2S | AGTR1A | AGTR1B | AT1 | AT1B | AT1R | AT2R1 | AT2R1A | AT2R1B | HAT1Rangiotensin II receptor, type 1-HPRD11279203 
AP1B1ADTB1 | AP105A | BAM22 | CLAPB2adaptor-related protein complex 1, beta 1 subunit-HPRD10097102 |12070169 
AP2B1ADTB2 | AP105B | AP2-BETA | CLAPB1 | DKFZp781K0743adaptor-related protein complex 2, beta 1 subunitReconstituted Complex
Two-hybrid		BioGRID10097102 |12070169 
AP3B1ADTB3 | ADTB3A | HPS | HPS2 | PEadaptor-related protein complex 3, beta 1 subunitAffinity Capture-MSBioGRID17353931 
ARF6DKFZp564M0264ADP-ribosylation factor 6-HPRD,BioGRID11533043 |11867621 
ARRB1ARB1 | ARR1arrestin, beta 1Affinity Capture-MSBioGRID17353931 
AVPR2ADHR | DI1 | DIR | DIR3 | MGC126533 | MGC138386 | NDI | V2Rarginine vasopressin receptor 2-HPRD,BioGRID12473660 
BOP1KIAA0124block of proliferation 1Affinity Capture-MSBioGRID17353931 
CLTCCHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034clathrin, heavy chain (Hc)-HPRD10097102 
CYTH2ARNO | CTS18 | CTS18.1 | PSCD2 | PSCD2L | SEC7L | Sec7p-L | Sec7p-likecytohesin 2-HPRD,BioGRID11533043 
DDX27DKFZp667N057 | FLJ12917 | FLJ20596 | FLJ22238 | HSPC259 | MGC1018 | MGC163147 | PP3241 | RHLP | Rrp3p | dJ686N3.1DEAD (Asp-Glu-Ala-Asp) box polypeptide 27Affinity Capture-MSBioGRID17353931 
FBLFIB | FLRN | RNU3IP1fibrillarinAffinity Capture-MSBioGRID17353931 
KPNA3IPOA4 | SRP1gamma | SRP4 | hSRP1karyopherin alpha 3 (importin alpha 4)Affinity Capture-MSBioGRID17353931 
KPNA4IPOA3 | MGC12217 | MGC26703 | QIP1 | SRP3karyopherin alpha 4 (importin alpha 3)Affinity Capture-MSBioGRID17353931 
LHCGRFLJ41504 | LCGR | LGR2 | LH/CG-R | LH/CGR | LHR | LHRHR | LSH-Rluteinizing hormone/choriogonadotropin receptorReconstituted ComplexBioGRID11867621 
MAP2K4JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SEK1 | SERK1mitogen-activated protein kinase kinase 4-HPRD,BioGRID11090355 
MAP3K5ASK1 | MAPKKK5 | MEKK5mitogen-activated protein kinase kinase kinase 5Affinity Capture-WesternBioGRID11090355 
-HPRD11356842 
MAPK10FLJ12099 | FLJ33785 | JNK3 | JNK3A | MGC50974 | PRKM10 | p493F12 | p54bSAPKmitogen-activated protein kinase 10-HPRD,BioGRID11090355 |11356842 
-HPRD11090355 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3Affinity Capture-WesternBioGRID12473660 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)-HPRD,BioGRID12488444 |12538596 
-HPRD11588219 |12488444 
|12538596|12488444 |12538596 
MED8ARC32 | MGC17544 | MGC19641mediator complex subunit 8Two-hybridBioGRID16169070 
MRPL43MGC17989 | MGC48892 | bMRP36amitochondrial ribosomal protein L43Affinity Capture-MSBioGRID17353931 
MRPL44FLJ12701 | FLJ13990 | FLJ37688 | L44MT | MRP-L44mitochondrial ribosomal protein L44Affinity Capture-MSBioGRID17353931 
NFKBIAIKBA | MAD-3 | NFKBInuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaThe amino terminus of Beta-Arr2 interacts with the carboxy terminus of I-kappa-B-alpha to prevent I-kappa-B-alpha phosphorylation and degradation.BIND15125834 
NOLC1KIAA0035 | NOPP130 | NOPP140 | NS5ATP13 | P130nucleolar and coiled-body phosphoprotein 1Affinity Capture-MSBioGRID17353931 
NTSNMN-125 | NN | NT | NT/N | NTS1neurotensin-HPRD12473660 
NTSR1NTRneurotensin receptor 1 (high affinity)-HPRD11279203 
OPRD1OPRDopioid receptor, delta 1-HPRD,BioGRID11259507 
OXTROT-Roxytocin receptor-HPRD11279203 
PDE4DDPDE3 | HSPDE4D | PDE4DN2 | STRK1phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)PDE4D5 interacts with Beta-Arrestin 2.BIND14500724 
PES1PESpescadillo homolog 1, containing BRCT domain (zebrafish)Affinity Capture-MSBioGRID17353931 
PTAFRPAFRplatelet-activating factor receptor-HPRD,BioGRID11729201 
-HPRD9037196 
RAB5CMGC117217 | MGC138857 | RAB5CL | RABLRAB5C, member RAS oncogene familyAffinity Capture-MSBioGRID17353931 
RALGDSFLJ20922 | RGF | RalGEFral guanine nucleotide dissociation stimulator-HPRD,BioGRID12105416 
RPL7L1MGC62004 | dJ475N16.4ribosomal protein L7-like 1Affinity Capture-MSBioGRID17353931 
SLC9A5NHE5solute carrier family 9 (sodium/hydrogen exchanger), member 5Beta-Arr2 interacts with NHE5.BIND15699339 
SMARCC2BAF170 | CRACC2 | Rsc8SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2Two-hybridBioGRID16169070 
SMOGx | SMOHsmoothened homolog (Drosophila)Beta-arr2 interacts with Smo. This interaction was modeled on a demonstrated interaction between Beta-arr2 and Smo both from an unspecified species.BIND15618519 
STC2STC-2 | STCRPstanniocalcin 2Two-hybridBioGRID16169070 
TCOF1MFD1 | treacleTreacher Collins-Franceschetti syndrome 1Affinity Capture-MSBioGRID17353931 
TRHMGC125964 | MGC125965thyrotropin-releasing hormone-HPRD12473660 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_OLFACTORY_TRANSDUCTION 38985All SZGR genes in this pathway
PID_WNT_NONCANONICAL_PATHWAY 3226All SZGR genes in this pathway
PID_NFKAPPAB_ATYPICAL_PATHWAY 1715All SZGR genes in this pathway
PID_ARF6_PATHWAY 3527All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_ALK1_PATHWAY 2621All SZGR genes in this pathway
PID_NEPHRIN_NEPH1_PATHWAY 3124All SZGR genes in this pathway
PID_IL8_CXCR2_PATHWAY 3426All SZGR genes in this pathway
PID_HEDGEHOG_2PATHWAY 2217All SZGR genes in this pathway
PID_HEDGEHOG_GLI_PATHWAY 4835All SZGR genes in this pathway
PID_IL8_CXCR1_PATHWAY 2819All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 2718All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH1 7046All SZGR genes in this pathway
REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 3220All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH 10364All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_DN 5135All SZGR genes in this pathway
LIU_CMYB_TARGETS_UP 165106All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN 158102All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
CHOW_RASSF1_TARGETS_UP 2717All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP 13187All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_UP 11168All SZGR genes in this pathway
BASSO_HAIRY_CELL_LEUKEMIA_DN 8066All SZGR genes in this pathway
WILENSKY_RESPONSE_TO_DARAPLADIB 2920All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_ALL_DISORDERS_DURATION_CORR_DN 14690All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_DN 1510All SZGR genes in this pathway
HOLLEMAN_ASPARAGINASE_RESISTANCE_ALL_DN 2514All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-3651921991A,m8hsa-miR-365UAAUGCCCCUAAAAAUCCUUAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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