Gene Page: MDK

Summary
GeneID  4192
Symbol  MDK
Synonyms  FLJ27379|MK|NEGF2
Description  midkine (neurite growth-promoting factor 2)
See related  HGNC:6972|MIM:162096|Ensembl:ENSG00000110492|HPRD:01200|
Locus tag  -
Gene type  protein-coding
Map location  11p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NEBL0.870.87
EPB41L20.860.90
MFAP3L0.850.89
ACSL60.850.89
MYLK0.850.82
SYNM0.840.89
SIRPA0.840.91
KIAA04940.840.83
DTNA0.840.87
TACC10.820.88
Top 10 negatively co-expressed genes
TUBB2B-0.62-0.55
KIAA1949-0.62-0.49
BCL7C-0.62-0.71
NXT1-0.62-0.66
RPS8-0.61-0.75
RPS19P3-0.61-0.78
RPS13P2-0.61-0.73
TRAF4-0.61-0.66
DYNLT1-0.61-0.74
ALKBH2-0.61-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008201heparin bindingIDA9384573 
GO:0008083growth factor activityIEA-
GO:0008083growth factor activityNAS1639750 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentNASneurite (GO term level: 5)9384573 
GO:0007165signal transductionNAS7835084 
GO:0008283cell proliferationIEA-
GO:0009611response to woundingISS-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationNAS1639750 
GO:0030325adrenal gland developmentISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTG1ACT | ACTG | DFNA20 | DFNA26actin, gamma 1Affinity Capture-MSBioGRID10772929 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD9452495 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD9452495 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD,BioGRID10772929 
LRP2DBS | gp330low density lipoprotein-related protein 2-HPRD10772929 
NCAM1CD56 | MSK39 | NCAMneural cell adhesion molecule 1Affinity Capture-MSBioGRID10772929 
NCLC23 | FLJ45706nucleolin-HPRD,BioGRID12147681 
NID1NIDnidogen 1Affinity Capture-MSBioGRID10772929 
NID2-nidogen 2 (osteonidogen)Affinity Capture-MSBioGRID10772929 
PTPRBDKFZp686E2262 | DKFZp686H15164 | FLJ44133 | HPTP-BETA | HPTPB | MGC142023 | MGC59935 | PTPB | R-PTP-BETA | VEPTPprotein tyrosine phosphatase, receptor type, B-HPRD10706604 
PTPRZ1HPTPZ | HPTPzeta | PTP-ZETA | PTP18 | PTPRZ | PTPZ | RPTPB | RPTPbeta | phosphacanprotein tyrosine phosphatase, receptor-type, Z polypeptide 1-HPRD,BioGRID10212223 |10706604 
RPL18A-ribosomal protein L18aTwo-hybridBioGRID16169070 
SDC1CD138 | SDC | SYND1 | syndecansyndecan 1-HPRD9089390 
SDC3N-syndecan | SDCN | SYND3syndecan 3-HPRD9089390 
SDC4MGC22217 | SYND4syndecan 4-HPRD8621465 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD9452495 
TGM1ICR2 | KTG | LI | LI1 | TGASE | TGKtransglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)-HPRD9384573 
TUBA1AB-ALPHA-1 | FLJ25113 | LIS3 | TUBA3tubulin, alpha 1aAffinity Capture-MSBioGRID10772929 
TUBB2BDKFZp566F223 | FLJ98847 | MGC8685 | TUBB-PARALOG | bA506K6.1tubulin, beta 2BAffinity Capture-MSBioGRID10772929 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_INTEGRIN1_PATHWAY 6644All SZGR genes in this pathway
PID_SYNDECAN_4_PATHWAY 3225All SZGR genes in this pathway
PID_INTEGRIN_A4B1_PATHWAY 3324All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_DN 8453All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_DN 242165All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP 271175All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_DN 186107All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_UP 6439All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_UP 10075All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER 178108All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_1 5133All SZGR genes in this pathway
KORKOLA_YOLK_SAC_TUMOR 6233All SZGR genes in this pathway
DACOSTA_ERCC3_ALLELE_XPCS_VS_TTD_UP 2819All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
HEIDENBLAD_AMPLICON_8Q24_DN 4628All SZGR genes in this pathway
FURUKAWA_DUSP6_TARGETS_PCI35_UP 7432All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_SUBSET 3320All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP 266171All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS 7441All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_UP 7856All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_AND_CD2_UP 8951All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
CUI_TCF21_TARGETS_UP 3727All SZGR genes in this pathway
KANG_FLUOROURACIL_RESISTANCE_UP 2215All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_24HR_DN 3321All SZGR genes in this pathway
ZHANG_ANTIVIRAL_RESPONSE_TO_RIBAVIRIN_UP 3021All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN 8858All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_WITHOUT_MGMT_48HR_DN 3225All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
BACOLOD_RESISTANCE_TO_ALKYLATING_AGENTS_UP 2617All SZGR genes in this pathway
WANG_LSD1_TARGETS_UP 2414All SZGR genes in this pathway
KANG_CISPLATIN_RESISTANCE_UP 1911All SZGR genes in this pathway
SASAI_TARGETS_OF_CXCR6_AND_PTCH1_DN 86All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_WITH_EPCAM_UP 5325All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_UP 166105All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_12 7954All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/5069096m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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