Gene Page: MEF2C

Summary
GeneID  4208
Symbol  MEF2C
Synonyms  -
Description  myocyte enhancer factor 2C
See related  HGNC:6996|MIM:600662|HPRD:02809|
Locus tag  -
Gene type  protein-coding
Map location  5q14
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TRHDE0.700.79
NCAM20.680.75
GABRB20.680.74
HOMER10.680.67
EXPH50.670.69
RYR20.670.75
AP000751.30.670.62
SLC4A100.670.74
HTR2A0.670.74
CNKSR20.670.69
Top 10 negatively co-expressed genes
GSTM2-0.37-0.47
AC135586.1-0.33-0.42
EFEMP2-0.33-0.23
RFXANK-0.32-0.38
NT5C-0.31-0.33
BCL7C-0.31-0.51
RAB13-0.31-0.42
FAM181B-0.30-0.47
PECI-0.29-0.33
RAB34-0.29-0.23
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityNAS8575763 
GO:0003702RNA polymerase II transcription factor activityTAS8455629 
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)8455629 
GO:0001568blood vessel developmentIEA-
GO:0001649osteoblast differentiationIEA-
GO:0002062chondrocyte differentiationIEA-
GO:0001958endochondral ossificationIEA-
GO:0001974blood vessel remodelingIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007517muscle developmentTAS8455629 
GO:0007507heart developmentIEA-
GO:0045941positive regulation of transcriptionIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EP300KAT3B | p300E1A binding protein p300Phenotypic Enhancement
Reconstituted Complex		BioGRID9001254 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4-HPRD10523670 |11504882 
Affinity Capture-Western
Reconstituted Complex		BioGRID10523670 |11486037 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14-HPRD9753748 |10330143 
MAPK7BMK1 | ERK4 | ERK5 | PRKM7mitogen-activated protein kinase 7-HPRD,BioGRID9753748 
An unspecified isoform of ERK5 phosphorylates MEF2C. This interaction was modeled on a demonstrated interaction between ERK5 from an unspecified species and MEF2C from an unspecified species.BIND12659851 
MEF2DDKFZp686I1536myocyte enhancer factor 2D-HPRD9858528 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1Two-hybridBioGRID9418854 
MYOGMYF4 | MYOGENIN | bHLHc3myogenin (myogenic factor 4)Reconstituted ComplexBioGRID8548800 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID11160896 
SOX18HLTSSRY (sex determining region Y)-box 18SOX18 directly interacts with MEF2C. This interaction is modeled on a demonstrated interaction between murine proteins.BIND11554755 
-HPRD,BioGRID11554755 
SP1-Sp1 transcription factor-HPRD,BioGRID9748305 
TEAD1AA | REF1 | TCF13 | TEF-1TEA domain family member 1 (SV40 transcriptional enhancer factor)Affinity Capture-Western
Reconstituted Complex		BioGRID12061776 
TWIST2DERMO1 | MGC117334 | bHLHa39twist homolog 2 (Drosophila)-HPRD,BioGRID11809751 
VGLL2VGL2 | VITO1vestigial like 2 (Drosophila)-HPRD12376544 
VGLL4KIAA0121 | VGL-4vestigial like 4 (Drosophila)-HPRD15140898 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY 3628All SZGR genes in this pathway
BIOCARTA_CARM_ER_PATHWAY 3527All SZGR genes in this pathway
BIOCARTA_HDAC_PATHWAY 3225All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
BIOCARTA_P38MAPK_PATHWAY 4031All SZGR genes in this pathway
BIOCARTA_PGC1A_PATHWAY 2620All SZGR genes in this pathway
BIOCARTA_ERK5_PATHWAY 1815All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_HDAC_CLASSII_PATHWAY 3427All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 3829All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY 3431All SZGR genes in this pathway
PID_RB_1PATHWAY 6546All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION 2420All SZGR genes in this pathway
REACTOME_ERK_MAPK_TARGETS 2117All SZGR genes in this pathway
REACTOME_MYOGENESIS 2820All SZGR genes in this pathway
REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 5037All SZGR genes in this pathway
REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 3024All SZGR genes in this pathway
REACTOME_CIRCADIAN_CLOCK 5340All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 7253All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP 201125All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_DN 6039All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP 15791All SZGR genes in this pathway
AKL_HTLV1_INFECTION_DN 6841All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_GRANULOCYTE_UP 5534All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP 14699All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_DN 13797All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP 197135All SZGR genes in this pathway
DUNNE_TARGETS_OF_AML1_MTG8_FUSION_DN 1917All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_DN 185115All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_DN 165107All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_DN 180110All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN 181107All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_APOBEC2 2719All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_6HR 4023All SZGR genes in this pathway
EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_UP 207128All SZGR genes in this pathway
TURJANSKI_MAPK7_TARGETS 88All SZGR genes in this pathway
TURJANSKI_MAPK11_TARGETS 55All SZGR genes in this pathway
TURJANSKI_MAPK14_TARGETS 1010All SZGR genes in this pathway
EBAUER_MYOGENIC_TARGETS_OF_PAX3_FOXO1_FUSION 5026All SZGR genes in this pathway
AMUNDSON_GENOTOXIC_SIGNATURE 10568All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_DN 7652All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_UP 9062All SZGR genes in this pathway
CHESLER_BRAIN_HIGHEST_GENETIC_VARIANCE 3721All SZGR genes in this pathway
ROSS_AML_WITH_MLL_FUSIONS 7845All SZGR genes in this pathway
SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_DN 4528All SZGR genes in this pathway
IIZUKA_LIVER_CANCER_EARLY_RECURRENCE 1110All SZGR genes in this pathway
ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN 7347All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
PARK_HSC_AND_MULTIPOTENT_PROGENITORS 5033All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP 13187All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
BASSO_CD40_SIGNALING_UP 10176All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
MCCLUNG_DELTA_FOSB_TARGETS_2WK 4836All SZGR genes in this pathway
EHRLICH_ICF_SYNDROM_DN 1513All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_UP 10072All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
TSENG_IRS1_TARGETS_UP 11371All SZGR genes in this pathway
NIKOLSKY_OVERCONNECTED_IN_BREAST_CANCER 2219All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION 8865All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
TOOKER_GEMCITABINE_RESISTANCE_UP 7940All SZGR genes in this pathway
PARK_APL_PATHOGENESIS_UP 1411All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN 235144All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_UP 7049All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
VALK_AML_CLUSTER_1 2819All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_36HR 2923All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE 15186All SZGR genes in this pathway
GENTLES_LEUKEMIC_STEM_CELL_UP 2915All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-135857863m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-1533984041Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-1823553621A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-183187518821A,m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-18818421848m8hsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-19108010861Ahsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-1942872931Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-203.1133113371Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-22316271633m8hsa-miR-223UGUCAGUUUGUCAAAUACCCC
hsa-miR-223UGUCAGUUUGUCAAAUACCCC
miR-23194519521A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-279759811Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-3p377383m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-323194519511Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-32916771683m8hsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-330875881m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-362115811641Ahsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
miR-376c17871793m8hsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-3818368421Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-4109429481Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-4487985m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-493-5p677683m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-4963303371A,m8hsa-miR-496AUUACAUGGCCAAUCUC
miR-505166316691Ahsa-miR-505GUCAACACUUGCUGGUUUCCUC
miR-539209120971Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-93.hd/291-3p/294/295/302/372/373/520200206m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
miR-963563621Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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