Gene Page: MEF2D

Summary
GeneID  4209
Symbol  MEF2D
Synonyms  DKFZp686I1536
Description  myocyte enhancer factor 2D
See related  HGNC:6997|MIM:600663|Ensembl:ENSG00000116604|HPRD:02810|
Locus tag  -
Gene type  protein-coding
Map location  1q12-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RPUSD30.840.84
MECR0.820.85
TRUB20.820.78
SLC25A110.820.76
OAZ10.810.82
MRPS70.810.79
POP40.810.81
MRPL170.810.81
ERI30.800.77
STOML20.800.79
Top 10 negatively co-expressed genes
AF347015.18-0.44-0.28
AC010300.1-0.42-0.45
EIF5B-0.39-0.44
AC100783.1-0.37-0.28
C10orf108-0.36-0.32
HSP90AB4P-0.36-0.36
AC016705.1-0.35-0.24
AF347015.26-0.35-0.20
ANP32C-0.35-0.36
AC005921.3-0.34-0.48
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0003700transcription factor activityNAS8575763 
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0007517muscle developmentTAS8269842 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CABIN1CAIN | KIAA0330 | PPP3INcalcineurin binding protein 1Affinity Capture-Western
Reconstituted Complex		BioGRID10531067 |10933397 
MEF2D interacts with CABIN1.BIND15902271 
EP300KAT3B | p300E1A binding protein p300Affinity Capture-WesternBioGRID10825153 |10933397 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4-HPRD,BioGRID10523670 
HDAC5FLJ90614 | HD5 | NY-CO-9histone deacetylase 5Affinity Capture-WesternBioGRID12896970 
MAPK7BMK1 | ERK4 | ERK5 | PRKM7mitogen-activated protein kinase 7-HPRD,BioGRID9753748 
MEF2AADCAD1 | RSRFC4 | RSRFC9myocyte enhancer factor 2A-HPRD,BioGRID8798771 |9858528 
MEF2C-myocyte enhancer factor 2C-HPRD9858528 
MEF2DDKFZp686I1536myocyte enhancer factor 2D-HPRD9858528 
NFATC2KIAA0611 | NFAT1 | NFATPnuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2-HPRD,BioGRID10944115 
SP1-Sp1 transcription factor-HPRD,BioGRID12213324 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID11433030 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_AT1R_PATHWAY 3628All SZGR genes in this pathway
BIOCARTA_HDAC_PATHWAY 3225All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_P38MAPK_PATHWAY 4031All SZGR genes in this pathway
BIOCARTA_PGC1A_PATHWAY 2620All SZGR genes in this pathway
BIOCARTA_ERK5_PATHWAY 1815All SZGR genes in this pathway
BIOCARTA_MEF2D_PATHWAY 2316All SZGR genes in this pathway
PID_HDAC_CLASSIII_PATHWAY 2520All SZGR genes in this pathway
PID_NFAT_3PATHWAY 5447All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_MYOGENESIS 2820All SZGR genes in this pathway
REACTOME_CIRCADIAN_CLOCK 5340All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP 175108All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_UP 207128All SZGR genes in this pathway
EBAUER_MYOGENIC_TARGETS_OF_PAX3_FOXO1_FUSION 5026All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
KIM_GASTRIC_CANCER_CHEMOSENSITIVITY 10364All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_UP 11168All SZGR genes in this pathway
KONDO_EZH2_TARGETS 245148All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_DN 10165All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_DN 204114All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN 8861All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_DN 8251All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/9812241230m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-101127512811Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-103/1073083151A,m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-12236883694m8hsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-125/351316431701Ahsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-144127512811Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-1833093315m8hsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-182310231091A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-19290296m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-21613681374m8hsa-miR-216UAAUCUCAGCUGGCAACUGUG
miR-219367736841A,m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-25/32/92/363/3678588651A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-2811681174m8hsa-miR-28brainAAGGAGCUCACAGUCUAUUGAG
miR-30-3p452458m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-369-3p1671731Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374167173m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-378*372637321Ahsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-485-5p2228m8hsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-96310331091Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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