Gene Page: NEFM

Summary
GeneID  4741
Symbol  NEFM
Synonyms  NEF3|NF-M|NFM
Description  neurofilament, medium polypeptide
See related  HGNC:7734|MIM:162250|Ensembl:ENSG00000104722|HPRD:01205|
Locus tag  -
Gene type  protein-coding
Map location  8p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0523 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005198structural molecule activityIEA-
GO:0005200structural constituent of cytoskeletonTAS3608989 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0031133regulation of axon diameterIEAaxon (GO term level: 14)-
GO:0008088axon cargo transportIEAaxon (GO term level: 8)-
GO:0000226microtubule cytoskeleton organizationIEA-
GO:0045110intermediate filament bundle assemblyIEA-
GO:0060052neurofilament cytoskeleton organizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0031594neuromuscular junctionIEAneuron, axon, Synap, Neurotransmitter (GO term level: 3)-
GO:0005883neurofilamentIEAneuron, axon (GO term level: 11)-
GO:0005883neurofilamentTASneuron, axon (GO term level: 11)3608989 
GO:0030424axonTASneuron, axon, Neurotransmitter (GO term level: 6)14662745 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APOEAD2 | LPG | MGC1571 | apoproteinapolipoprotein EReconstituted ComplexBioGRID8620924 
NEFHNFHneurofilament, heavy polypeptide-HPRD2557834 
STXBP1EIEE4 | MUNC18-1 | UNC18 | hUNC18 | rbSec1syntaxin binding protein 1-HPRD12963086 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
DAVICIONI_PAX_FOXO1_SIGNATURE_IN_ARMS_DN 2015All SZGR genes in this pathway
KIM_RESPONSE_TO_TSA_AND_DECITABINE_UP 12973All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_DN 6849All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP 14699All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP 201127All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_DN 5745All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_C 11347All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
SMITH_TERT_TARGETS_DN 8769All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
BASSO_CD40_SIGNALING_UP 10176All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
MCCLUNG_DELTA_FOSB_TARGETS_2WK 4836All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_UP 10072All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_UP 11168All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G2 3018All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_UP 181112All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
MALONEY_RESPONSE_TO_17AAG_UP 4126All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 142103All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G24 2819All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D 280158All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
GHANDHI_DIRECT_IRRADIATION_UP 11068All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/983533591Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-124.13203261Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-125/351144150m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-13525321A,m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-1503893951Ahsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-242852921A,m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-25/32/92/363/3671171241A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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