Gene Page: NFKBIE

Summary
GeneID  4794
Symbol  NFKBIE
Synonyms  IKBE
Description  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
See related  HGNC:7799|MIM:604548|Ensembl:ENSG00000146232|HPRD:05181|
Locus tag  -
Gene type  protein-coding
Map location  6p21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0193 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NFATC10.620.59
SLC12A40.610.56
NKX2-20.610.57
HAP10.610.61
AC135457.10.590.67
HEY20.590.63
B3GNT90.590.65
ITPRIPL20.580.59
TIMP30.580.61
ITIH50.580.63
Top 10 negatively co-expressed genes
NR2C2AP-0.42-0.55
COMMD3-0.40-0.55
CYP2R1-0.39-0.55
POLB-0.39-0.54
STMN1-0.39-0.48
ZNF32-0.38-0.54
ING4-0.38-0.51
BZW2-0.38-0.48
PARP6-0.38-0.45
DUSP12-0.38-0.49
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI16716191 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042994cytoplasmic sequestering of transcription factorTAS9135156 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmTAS9135156 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANKHD1MASK | VBARPankyrin repeat and KH domain containing 1-HPRD14743216 
ANKHD1-EIF4EBP3MASK-BP3 | MASK-BP3arfANKHD1-EIF4EBP3 readthrough transcript-HPRD14743216 
ANKRD17FLJ22206 | GTAR | KIAA0697 | NY-BR-16ankyrin repeat domain 17-HPRD14743216 
ANKRD28KIAA0379 | PITKankyrin repeat domain 28-HPRD14743216 
ARHGEF2DKFZp547L106 | DKFZp547P1516 | GEF | GEF-H1 | GEFH1 | KIAA0651 | LFP40 | P40rho/rac guanine nucleotide exchange factor (GEF) 2-HPRD14743216 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD14743216 
IL1AIL-1A | IL1 | IL1-ALPHA | IL1F1interleukin 1, alpha-HPRD10998424 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobinTwo-hybridBioGRID16189514 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1-HPRD9223487 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9315679 
NFKB2LYT-10 | LYT10nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)p52 interacts with I-kappa-B-epsilon. This interaction was modeled on a demonstrated interaction between p52 from an unspecified species and human I-kappa-B-epsilon.BIND9135156 
-HPRD,BioGRID9315679 
RELC-Relv-rel reticuloendotheliosis viral oncogene homolog (avian)Affinity Capture-Western
Reconstituted Complex		BioGRID8415639 |9315679 
|10706725 
-HPRD8139561 |8415639 
|10706725 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9315679 
RUVBL2CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49BRuvB-like 2 (E. coli)-HPRD14743216 
SAPS1KIAA1115 | MGC138185 | MGC142003 | PP6R1 | SAP190SAPS domain family, member 1-HPRD14743216 
SAPS2KIAA0685 | PP6R2 | SAP190 | dJ579N16.1SAPS domain family, member 2-HPRD14743216 
SAPS3C11orf23 | DKFZp781E17107 | DKFZp781E2374 | DKFZp781O2362 | FLJ11058 | FLJ43065 | KIAA1558 | MGC125711 | MGC125712 | PP6R3 | SAP190 | SAPL | SAPLaSAPS domain family, member 3-HPRD14743216 
TUBA3CTUBA2 | bA408E5.3tubulin, alpha 3c-HPRD14743216 
UACAFLJ10128 | KIAA1561 | MGC141967 | MGC141969 | NUCLINGuveal autoantigen with coiled-coil domains and ankyrin repeats-HPRD14743216 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 7556All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
ST_TUMOR_NECROSIS_FACTOR_PATHWAY 2920All SZGR genes in this pathway
SIG_CD40PATHWAYMAP 3428All SZGR genes in this pathway
ST_GAQ_PATHWAY 2822All SZGR genes in this pathway
ST_GA13_PATHWAY 3732All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION 4533All SZGR genes in this pathway
ST_B_CELL_ANTIGEN_RECEPTOR 4032All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 6443All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP 206111All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP 170114All SZGR genes in this pathway
GILMORE_CORE_NFKB_PATHWAY 1410All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_EARLY 6648All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
TSAI_RESPONSE_TO_IONIZING_RADIATION 149101All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED 10068All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_DN 3825All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
BASSO_CD40_SIGNALING_UP 10176All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_CLUSTER_DN 4026All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_DN 7834All SZGR genes in this pathway
SEKI_INFLAMMATORY_RESPONSE_LPS_UP 7756All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_A 6752All SZGR genes in this pathway
PARK_APL_PATHOGENESIS_DN 5035All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_DN 240153All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_DN 5438All SZGR genes in this pathway
TIAN_TNF_SIGNALING_VIA_NFKB 2821All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_UP 169105All SZGR genes in this pathway
KRIEG_HYPOXIA_VIA_KDM3A 5334All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway


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