Gene Page: PARD6A

Summary
GeneID  50855
Symbol  PARD6A
Synonyms  PAR-6A|PAR6|PAR6C|PAR6alpha|TAX40|TIP-40
Description  par-6 partitioning defective 6 homolog alpha (C. elegans)
See related  HGNC:15943|MIM:607484|Ensembl:ENSG00000102981|HPRD:06316|
Locus tag  -
Gene type  protein-coding
Map location  16q22.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0447 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008134transcription factor bindingTAS9482110 
GO:0017048Rho GTPase bindingISS-
GO:0030742GTP-dependent protein bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016032viral reproductionTAS9482110 
GO:0007049cell cycleIEA-
GO:0051301cell divisionIEA-
GO:0045217cell-cell junction maintenanceISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0005923tight junctionISSBrain (GO term level: 10)-
GO:0005634nucleusISS-
GO:0005737cytoplasmIEA-
GO:0005938cell cortexIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID10873802 |10934474 
|11260256 
-HPRD10873802|11260256 
CRB3-crumbs homolog 3 (Drosophila)-HPRD14718572 
ECT2FLJ10461 | MGC138291epithelial cell transforming sequence 2 oncogene-HPRD,BioGRID15254234 
MPP5FLJ12615 | PALS1membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)Affinity Capture-WesternBioGRID12545177 
PARD3ASIP | Baz | Bazooka | FLJ21015 | PAR3 | PAR3alpha | PARD3A | SE2-5L16 | SE2-5LT1 | SE2-5T2par-3 partitioning defective 3 homolog (C. elegans)Affinity Capture-WesternBioGRID12459187 
PLCB1FLJ45792 | PI-PLC | PLC-154 | PLC-I | PLC154phospholipase C, beta 1 (phosphoinositide-specific)PLCB1 (PLC-beta-1) interacts with PARD6A (Par6). This interaction was modeled on a demonstrated interaction between rat PLCB1 and human Par6.BIND15782111 
PLCB3FLJ37084phospholipase C, beta 3 (phosphatidylinositol-specific)PLCB3 (PLC-beta-3) interacts with PARD6A (Par6)BIND15782111 
PRKCIDXS1179E | MGC26534 | PKCI | nPKC-iotaprotein kinase C, iotaTwo-hybridBioGRID16189514 
PRKCZPKC-ZETA | PKC2protein kinase C, zeta-HPRD,BioGRID11260256 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD,BioGRID11260256 
RHOQARHQ | RASL7A | TC10 | TC10Aras homolog gene family, member QTwo-hybridBioGRID10934474 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 5141All SZGR genes in this pathway
PID_RHOA_PATHWAY 4533All SZGR genes in this pathway
PID_INSULIN_PATHWAY 4532All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_NEPHRIN_NEPH1_PATHWAY 3124All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION 167All SZGR genes in this pathway
REACTOME_CELL_CELL_JUNCTION_ORGANIZATION 5631All SZGR genes in this pathway
REACTOME_TIGHT_JUNCTION_INTERACTIONS 2911All SZGR genes in this pathway
REACTOME_CELL_JUNCTION_ORGANIZATION 7843All SZGR genes in this pathway
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 6342All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP 201125All SZGR genes in this pathway
KIM_RESPONSE_TO_TSA_AND_DECITABINE_UP 12973All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
WATTEL_AUTONOMOUS_THYROID_ADENOMA_UP 7347All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
SWEET_KRAS_TARGETS_DN 6639All SZGR genes in this pathway
MARCINIAK_ER_STRESS_RESPONSE_VIA_CHOP 2517All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
LU_EZH2_TARGETS_UP 295155All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_DN 211119All SZGR genes in this pathway


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